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Tethered Bilayer Lipid Membranes to Monitor Heat Transfer between Gold Nanoparticles and Lipid Membranes
 

Tethered Bilayer Lipid Membranes to Monitor Heat Transfer between Gold Nanoparticles and Lipid Membranes

Article DOI: 10.3791/61851-v • 07:33 min • December 8th, 2020
December 8th, 2020 •
1,2, 1, 3, 3, 1,2, 3, 2,4, 1,2,5
1School of Life Sciences, University of Technology Sydney, 2ARC Research Hub for Integrated Devices for End-user Analysis at Low-levels (IDEAL), Faculty of Science, University of Technology Sydney, 3School of Mechanical and Manufacturing Engineering, The University of New South Wales, 4Surgical Diagnostics Pty Ltd., 5Institute for Biomedical Materials and Devices, University of Technology Sydney

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Summary
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This work outlines a protocol to achieve dynamic, non-invasive monitoring of heat transfer from laser-irradiated gold nanoparticles to tBLMs. The system combines impedance spectroscopy for the real-time measurement of conductance changes across the tBLMs, with a horizontally focused laser beam that drives gold nanoparticle illumination, for heat production.

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Keywords: Tethered Bilayer Lipid Membranes Gold Nanoparticles Photothermal Effects Cell Membrane Biomimetic Membrane Conductance Capacitance Nanoparticle Therapies Cancer Therapy Laser Parameters Particle Size Particle Coatings Particle Composition
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