A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

Ilias P. Doulamis; Alvise Guariento; Mossab Y. Saeed; Rio S. Nomoto; Thomas Duignan; Pedro J. del Nido; James D. McCully

doi:10.3791/62230

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A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

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JoVE Journal Medicine

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

DOI:

10.3791/62230-v

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09:02 min

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February 02, 2021

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Ilias P. Doulamis, Alvise Guariento, Mossab Y. Saeed, Rio S. Nomoto, Thomas Duignan, Pedro J. del Nido, James D. McCully

¹Department of Cardiac Surgery, Boston Children’s Hospital,Harvard Medical School

Chapters

00:05Introduction
00:56Surgical Preparation and Vascular Access
02:16Induction of Renal Ischemia-Reperfusion Injury
05:37Post-Reperfusion
06:37Results: Assessment of Renal Function Before and After Renal Ischemia-Reperfusion Injury
08:23Conclusion

Summary

Automatic Translation

This study presents a highly reproducible large animal model of renal ischemia-reperfusion injury in swine using temporary percutaneous bilateral balloon-catheter occlusion of the renal arteries for 60 min and reperfusion for 24 h.

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

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