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Anvendelse af ultralyd og forskydning bølge elastografi Imaging i en rotte model af NAFLD / NASH
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JoVE Journal Biology
Application of Ultrasound and Shear Wave Elastography Imaging in a Rat Model of NAFLD/NASH

Anvendelse af ultralyd og forskydning bølge elastografi Imaging i en rotte model af NAFLD / NASH

DOI:
10.3791/62403-v

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07:13 min

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April 20, 2021

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, , , , ,
1Comparative Medicine,Pfizer Inc., 2Digital Medicine & Translational Imaging,Pfizer Inc., 3Internal Medicine Research Unit,Pfizer Inc., 4Drug Safety Research & Development,Pfizer Inc.

Chapters

  • 00:05Introduction
  • 00:40Preparation of Rat for Imaging and Instrument Set-up
  • 02:01Image Acquisition for Hepato-Renal (HR) Index Measurement
  • 03:27Image Acquisition for the Shear Wave Elastography
  • 04:43Image Data Retrieval
  • 05:12Results: Analysis of the Hepato-renal Index and Shear Wave Elastography in High-fat and Control Diet Groups
  • 06:37Conclusion

Summary

Automatic Translation

Automatic Translation

Denne protokol beskriver brugen af en forbedret ultralydsteknik til ikke-invasivt at observere og kvantificere levervævsændringer i gnavermodeller af ikke-alkoholisk fedtleversygdom.

Tags

Keywords: UltrasoundShear Wave ElastographyNAFLDNASHRat ModelNon-invasiveHigh-throughputDrug DiscoveryCholine Deficient High-fat DietAnesthesiaChemical DepilationB-mode ImagingRenal CortexLiver Parenchyma

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