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斑马鱼神经母细胞瘤转移模型
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Cancer Research
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JoVE Journal Cancer Research
Zebrafish Model of Neuroblastoma Metastasis
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斑马鱼神经母细胞瘤转移模型

DOI:
10.3791/62416-v

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05:20 min

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March 14, 2021

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, , , ,
1Department of Biochemistry and Molecular Biology,Mayo Clinic College of Medicine, Mayo Clinic Cancer Center

Chapters

  • 00:04Introduction
  • 00:57Outcross of LMO1 and MYCN Transgenic Lines to Create Metastatic Model
  • 02:11Visualizing Tumor Burden in Transgenic Zebrafish Lines
  • 03:17Results: Transgenic Zebrafish Model Overexpressing MYCN and LMO1 for Neuroblastoma Metastasis
  • 04:50Conclusion

Summary

Automatic Translation

Automatic Translation

本文介绍了实时开发、表征和跟踪斑马鱼神经母细胞瘤模型肿瘤转移的方法，特别是在 MYCN 和 LMO1过表达的转基因斑马鱼品系中，该谱系自发地发生转移。

Tags

Keywords: ZebrafishNeuroblastomaMetastasisIn Vivo ImagingTumor DisseminationMYCNLMO1TransgenicEGFPFluorescence MicroscopeTumor ScreeningTumor-bearing FishTumor Cell Migration

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