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Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
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Cancer Research
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JoVE Journal Cancer Research
Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

DOI:
10.3791/62560-v

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07:57 min

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March 24, 2022

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, , , , , ,
1Department of Diagnostic Sciences,Ghent University, 2Department of Electronics and Information Systems,Ghent University, 3Department of Head and Skin,Ghent University

Chapters

  • 00:05Introduction
  • 00:36Multimodality Imaging of Target Volume Selection
  • 02:33Image Co-registration
  • 03:15Radiation Treatment Planning: Method 1
  • 05:15Radiation Treatment Planning: Method 2
  • 06:26Results: A Comparison Between the Two Methods for PET-based Dose Painting Radiation Therapy
  • 07:29Conclusion

Summary

Automatic Translation

Automatic Translation

Here we present a protocol to perform preclinical positron emission tomography-based radiotherapy in a rat glioblastoma model using algorithms developed in-house to optimize the accuracy and efficiency.

Tags

Keywords: PETPositron Emission TomographyDose PaintingRadiation TherapyGlioblastomaRat ModelSmall Animal Radiation Research PlatformF98 GlioblastomaFluorine-18 FETMRIContrast AgentCone Beam CTImage Co-registrationMATLABDose Painting Co-registration

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