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JoVE Journal Cancer Research
An Ex Vivo Brain Slice Model to Study and Target Breast Cancer Brain Metastatic Tumor Growth
 

An Ex Vivo Brain Slice Model to Study and Target Breast Cancer Brain Metastatic Tumor Growth

Article DOI: 10.3791/62617-v • 10:38 min • September 22nd, 2021
September 22nd, 2021 •
1, 1, 1, 1, 2,4, 3,4, 2, 1,4
1Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, 2Department of Pharmacology and Physiology, Drexel University College of Medicine, 3Department of Radiation Oncology, Thomas Jefferson University, 4Sidney Kimmel Cancer Center, Thomas Jefferson University

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Summary
Automatic Translation

We introduce a protocol for measuring real-time drug and radiation response of breast cancer brain metastatic cells in an organotypic brain slice model. The methods provide a quantitative assay to investigate the therapeutic effects of various treatments on brain metastases from breast cancer in an ex vivo manner within the brain microenvironment interface.

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Keywords: Brain Metastasis Ex Vivo Brain Slice Model Breast Cancer Drug Efficacy Testing Tumor Growth Brain-tumor-host Interactions Brain Tumor Microenvironment
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