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Retinal Pigment Epitel Transplantation i en ikke-human primat model for degenerative retinale sygdomme
JoVE Journal
Medicine
This content is Free Access.
JoVE Journal Medicine
Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases
DOI:

11:20 min

June 14, 2021

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Chapters

  • 00:04Introduction
  • 01:22Vitrectomy
  • 04:13Microscope-Integrated Optical Coherence Tomography (miOCT)-Guided Foveal Detachment
  • 05:49Removal of Native Retinal Pigment Epithelium
  • 06:21miOCT-Guided Graft Implantation, Position Adjustment, and Subretinal Fluid Drainage
  • 08:33Results: Assessment of the Retinal Pigment Epithelial Graft
  • 10:33Conclusion

Summary

Automatic Translation

Den ikke-menneskelige primat (NHP) er en ideel model til at studere human retinal cellulær terapi på grund af de anatomiske og genetiske ligheder. Dette manuskript beskriver en metode til submakulær transplantation af retinale pigment epitelceller i NHP øje og strategier til at forhindre intraoperative komplikationer forbundet med makula manipulation.

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