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Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease
 

Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease

Article DOI: 10.3791/62970-v 05:51 min October 14th, 2021
October 14th, 2021

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Summary

This article describes methods to induce and evaluate levodopa-induced dyskinesias in a rat model of Parkinson's disease. The protocol offers detailed information regarding the intensity and frequency of a range of dyskinetic behaviors, both dystonic and hyperkinetic, providing a reliable tool to test treatments targeting this unmet medical need.

Tags

Keywords: Levodopa-induced Dyskinesia Parkinson's Disease Rat Model Induction Assessment Rating Scale Animal Model L-DOPA Benserazide Subcutaneous Injection
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