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研究角膜伤口愈合的上皮擦伤模型
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JoVE Journal Medicine
An Epithelial Abrasion Model for Studying Corneal Wound Healing
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研究角膜伤口愈合的上皮擦伤模型

DOI:
10.3791/63112-v

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04:45 min

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December 29, 2021

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, , , ,
1College of Optometry,University of Houston, 2Children’s Nutrition Research Center,Baylor College of Medicine, 3Center for Translational Research on Inflammatory Diseases (CTRID),Michael E. DeBakey Veterans Affairs Medical Center

Chapters

  • 00:05Introduction
  • 00:47Preparation and Anesthesia
  • 01:34Creation of Corneal Wound, Monitoring of Wound Closure, and Re-Epithelialization
  • 03:30Results: Inflammatory Response and Wound Closure Following Central Corneal Epithelial Abrasion
  • 04:18Conclusion

Summary

Automatic Translation

Automatic Translation

这里，描述了使用环锯和钝高尔夫球杆螺杆在小鼠中形成中央角膜上皮擦伤伤口的方案。这种角膜伤口愈合模型具有高度可重复性，现在正用于评估疾病背景下受损的角膜伤口愈合。

Tags

Keywords: Epithelial AbrasionCorneal Wound HealingCorneal InflammationCorneal Wounding ModelFluorescein StainingWound ClosureRe-epithelializationImage Analysis

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