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A Rodent Model of The Ross Operation: Syngeneic Pulmonary Artery Graft Implantation in A Systemic Position
JoVE Journal
Medicine
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JoVE Journal Medicine
A Rodent Model of The Ross Operation: Syngeneic Pulmonary Artery Graft Implantation in A Systemic Position
DOI:

11:20 min

April 01, 2022

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Chapters

  • 00:07Introduction
  • 01:32Preoperative Protocol
  • 02:15Donor Operation
  • 03:34Pulmonary Artery Graft Implantation
  • 07:08Postoperative Care and Follow-Up
  • 07:45Representative Results
  • 09:59Conclusions

Summary

Automatic Translation

We demonstrate how to establish a murine model of pulmonary root implantation into the descending aorta to simulate the Ross procedure. This model enables the medium/long-term evaluation of pulmonary autograft remodeling in a systemic position, representing the basis of developing therapeutic strategies to promote its adaptation.

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