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In vivo Positronemissionstomografi for at afsløre aktivitetsmønstre induceret af dyb hjernestimulering hos rotter
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1Centro Nacional de Investigaciones Cardiovasculares (CNIC), 2Laboratorio de Imagen Médica,Instituto de Investigación Sanitaria Gregorio Marañón, 3Departamento de Bioingeniería e Ingeniería Aeroespacial,Universidad Carlos III de Madrid, 4CIBER de Salud Mental (CIBERSAM), 5High Performance Research Group in Physiopathology and Pharmacology of the Digestive System (NeuGut),Universidad Rey Juan Carlos
Chapters
- 00:04Introduction
- 00:50Brain Target Localization by In Vivo Neuroimaging
- 02:12Stereotaxic Surgery
- 05:56PET-CT Imaging Acquisition
- 06:46DBS Stimulator Configuration
- 07:30Results: Evaluating the Consequences of Deep Brain Stimulation via In Vivo Neuroimaging
- 08:46Conclusion
Vi beskriver en præklinisk eksperimentel metode til at evaluere metabolisk neuromodulation induceret af akut dyb hjernestimulering med in vivo FDG-PET. Dette manuskript omfatter alle eksperimentelle trin, fra stereotaxisk kirurgi til anvendelse af stimuleringsbehandling og erhvervelse, behandling og analyse af PET-billeder.
