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Chapters
- 00:04Introduction
- 01:30Workflow for Ultrasound M‐Mode or Apical View DICOM Image Analysis and LV Parameter Extraction
- 02:34PAK Finite Element Solver for Fluid‐Structure (FS) Simulations
- 04:30Determination of Ventricular Activation Sequence from ECG Measurement
- 06:27Results: Fibers Direction, Velocity, Pressure Field, and Displacements in the Parametrical LV Model, Simulation of Whole‐Heart Activation, and Maps of Body Surface Potential
- 08:17Conclusion
This protocol demonstrates the workflow of the SILICOFCM platform for automatically generating a parametric model of the left ventricle from patient-specific ultrasound images by applying a multi-scale electromechanical model of the heart. This platform enables in silico clinical trials intended to reduce real clinical trials and maximize positive therapeutic outcomes.
Tags
Keywords:
In Silico Clinical TrialsCardiovascular DiseaseSilico FCM PlatformLeft VentriclePatient-specific Ultrasound ImagesElectromechanical ModelHeartDrug EffectsBoundary ConditionsECGCalcium FunctionHeart MuscleCardiomyopathyHeart FailureCardiac IschemiaArrhythmiaAtrial FibrillationVirtual Population ModuleUltrasound M-ModeApical View WorkflowDICOM FilesGeometryShaded ModelWire Frame ModelInlet And Outlet VelocitiesFinite Element MeshPatient-specific Condition
