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磷酸钙诱导的小鼠腹主动脉瘤模型

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Biology

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JoVE Journal Biology

A Calcium Phosphate-Induced Mouse Abdominal Aortic Aneurysm Model

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磷酸钙诱导的小鼠腹主动脉瘤模型

DOI:

10.3791/64173-v

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05:14 min

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November 18, 2022

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Siting Zhang*¹, Zeyu Cai*¹, Xu Zhang, Tianfeng Ma, Wei Kong

¹Department of Physiology and Pathophysiology, School of Basic Medical Sciences; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education,Peking University, ²Department of Vascular and Endovascular Surgery, the First Medical Centre,Chinese PLA General Hospital

Chapters

00:05Introduction
00:55Preparation and Surgical Procedure
03:05Harvesting for Imaging of Aortas and Evaluation of the Degradation of the Elastic Fibers
03:47Results: Pathological Features and Molecular Mechanisms of Calcium Phosphate-Induced Abdominal Aortic Aneurysm
04:15Conclusion

Summary

Automatic Translation

该协议描述了磷酸钙诱导的腹主动脉瘤（AAA）小鼠模型，以研究AAA的病理特征和分子机制。

Tags

Keywords: Calcium Phosphate Abdominal Aortic Aneurysm Mouse Model Infrarenal Aorta Adventitia Calcium Chloride PBS Suture Surgery Anesthesia Monitoring

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