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斑马鱼幼虫作为评估潜在放射增敏剂或保护剂的模型
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Cancer Research
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JoVE Journal Cancer Research
Zebrafish Larvae as a Model to Evaluate Potential Radiosensitizers or Protectors
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斑马鱼幼虫作为评估潜在放射增敏剂或保护剂的模型

DOI:
10.3791/64233-v

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04:53 min

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August 25, 2022

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, , , , ,
1Tumor microenvironment and animal models lab,Institute of Life Sciences, 2Vascular Biology lab,Institute of Life Sciences, 3Regional Centre for Biotechnology, 4School of Biotechnology,KIIT University

Chapters

  • 00:04Introduction
  • 00:57Monitoring Embryos and Selection for Radiation Experiments
  • 01:28X‐Ray Irradiation
  • 02:38Data Collection, Imaging, and Analysis
  • 03:17Results: Effect of Different Doses of X‐Ray Irradiation on 6 hpf Zebrafish Embryos
  • 04:23Conclusion

Summary

Automatic Translation

Automatic Translation

斑马鱼最近被用作验证潜在辐射改性剂的模型。本方案描述了使用斑马鱼胚胎进行基于辐射的筛选实验的详细步骤以及一些观察方法来评估不同治疗和辐射的效果。

Tags

Zebrafish LarvaeRadiation ScreeningRadiosensitizersRadioprotectorsRadiation-based ExperimentsHigh-throughput Drug ScreeningRadiobiologyRadiotherapyX-ray IrradiationEmbryo StagingObservational ApproachesSurvivalHatching EfficiencyDevelopmental StagesPhenotypic Changes

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