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1Department of Anatomy, Cell Biology and Physiology,Indiana University School of Medicine, 2Department of Orthopaedic Surgery,Indiana University School of Medicine, 3Indiana Center for Musculoskeletal Health,Indiana University School of Medicine, 4School of Mechanical Engineering,Purdue University, 5Large Animal Resource Center,Indiana University School of Medicine, 6Department of Mechanical and Energy Engineering,Indiana University-Purdue University Indianapolis
Chapters
- 00:04Introduction
- 00:47Animal Preparation
- 01:49Surgical Exposure
- 03:36Impact of the Femoral Condyle
- 05:25Surgical Site Closure
- 06:23Results: Assessing Osteoarthritis Severity and Apoptotic Chondrocytes in the Impacted Medial Femoral Condyle
- 07:58Conclusion
O modelo aberto de impacto do côndilo femoral medial em coelhos é confiável para estudar a osteoartrite pós-traumática (PTOA) e novas estratégias terapêuticas para mitigar a progressão da PTOA. Este protocolo gera um defeito cartilaginoso isolado do côndilo femoral medial posterior em coelhos utilizando uma torre de queda baseada em carruagem com cabeça de impacto.
