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Translationelle ortopiske modeller af glioblastom multiforme
JoVE Journal
Cancer Research
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JoVE Journal Cancer Research
Translational Orthotopic Models of Glioblastoma Multiforme
DOI:

07:37 min

February 17, 2023

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Chapters

  • 00:04Introduction
  • 01:23Surgical Area and Mouse Preparation
  • 03:34Cell Injection, Needle Removal, and Wound Closure
  • 05:53Results: Assessment of an Orthotopic Mouse Tumor Model for Human Glioblastoma Multiforme
  • 06:55Conclusion

Summary

Automatic Translation

Her beskriver vi en præklinisk ortopisk musemodel for GBM, etableret ved intrakraniel injektion af celler afledt af genetisk manipulerede musemodeltumorer. Denne model viser sygdomskendetegnene for human GBM. Til translationelle undersøgelser spores musehjernetumoren ved in vivo MR og histopatologi.

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