JoVE Journal
Medicine
Medicine
A subscription to JoVE is required to view this content. Sign in or start your free trial.
Chapters
Summary
Partial sciatic nerve ligation induces long-lasting chronic neuropathic pain, characterized by exaggerated responses to thermal and mechanical stimuli. This mouse model of neuropathic pain is commonly used to study innovative therapies for pain management. This article describes in detail the surgical procedure to improve standardization and reproducibility.