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Etablering og karakterisering af patientafledte xenograftmodeller af anaplastisk thyreoideakarcinom og pladecellekarcinom i hoved og hals
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Cancer Research
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JoVE Journal Cancer Research
Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma

Etablering og karakterisering af patientafledte xenograftmodeller af anaplastisk thyreoideakarcinom og pladecellekarcinom i hoved og hals

DOI:
10.3791/64623-v

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06:08 min

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June 02, 2023

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, , , , , , , , ,
1Precision Medicine Research Center, Sichuan Provincial Key Laboratory of Precision Medicine, National Clinical Research Center for Geriatrics, West China Hospital,Sichuan University, 2Department of Thyroid Surgery, West China Hospital,Sichuan University, 3Sichuan Kangcheng Biotech Co., 4Sichuan Cancer Hospital

Chapters

  • 00:04Introduction
  • 01:03Tumor Transplantation and Preservation
  • 02:49Resuscitation of Patient-Derived Xenograft (PDX) Model Tumors
  • 03:57Results: Tumor Growth Assessment & Effect of Lenvatinib and Cisplatin on PDX Model Tumors
  • 05:28Conclusion

Summary

Automatic Translation

Automatic Translation

Denne protokol etablerer og karakteriserer en patientafledt xenograft (PDX) model af anaplastisk skjoldbruskkirtelkarcinom (ATC) og pladecellekarcinom i hoved og hals (HNSCC), da PDX-modeller hurtigt er ved at blive standarden inden for translationel onkologi.

Tags

Patient-derived XenograftPDXAnaplastic Thyroid CarcinomaATCHead And Neck Squamous Cell CarcinomaHNSCCTumor HeterogeneityMolecular DiversityPersonalized TreatmentAnti-cancer Drug Sensitivity ScreeningTumor TransplantationSubcutaneousCryopreservationTumor Growth Curve

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