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Micro-Computed Tomography Analysis of the Knee in Aged Dunkin-Hartley Guinea Pigs after Intra Articular Injection
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Micro-Computed Tomography Analysis of the Knee in Aged Dunkin-Hartley Guinea Pigs after Intra Articular Injection

Micro-Computed Tomography Analysis of the Knee in Aged Dunkin-Hartley Guinea Pigs after Intra Articular Injection

DOI:
10.3791/66053-v

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07:10 min

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August 02, 2024

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, , , , ,
1Drug Discovery and Biomedical Sciences,Medical University of South Carolina, 2Department of Biomedical Science,The University of Alabama at Birmingham, 3Department of Comparative Medicine,Medical University of South Carolina

Chapters

  • 00:05Introduction
  • 01:25Intra-Articular Injection Preparations
  • 01:57Intra-Articular Injection
  • 02:30Recovery from Intra-Articular Injection
  • 03:00Image Processing for Evaluating Bone Microarchitectural Parameters
  • 03:19Collection of Microarchitectural Data from Reconstructed Images
  • 04:16Representative Results
  • 05:44Conclusion

Summary

Automatic Translation

Automatic Translation

Dunkin-Hartley guinea pigs are an established animal model for osteoarthritis research. Such studies may benefit from intra-articular injections for various reasons, including investigating novel agents or treating disease. We describe a methodology for intra-articular knee injections in Guinea pigs and subsequent micro-computed tomography analysis assessing arthritis-associated knee changes.

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Intra-articular injectionknee injectionguinea pigosteoarthritisanimal modelMicro-Computed Tomography

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