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Chapters
- 00:00Title
- 00:11Introduction
- 00:47Setting Up Instruments and Preparing Animals for Surgery
- 01:47Performing the Stereotaxic Surgery
- 07:26Conclusion
The monitoring of extracellular neurotransmitter levels in distinct brain regions of freely moving animals offers insights on the link between neurotransmitter release and behavior. In vivo microdialysis coupled with electrochemical detection provides excellent anatomical and chemical resolution; and information on how basal neurotransmission is altered by pharmacological or physiological manipulations.
Tags
Survivable Stereotaxic SurgeryRodentsExtracellular Basal LevelsNeurotransmittersAwake AnimalsSystemic ChallengesCNSMidbrain Dopamine ProjectionsDopamine-releasing DrugsD-amphetamineNatural StimuliFoodGuide CannulasRat BrainMicrodialysis ProbeHigh Performance Liquid ChromatographyElectrochemical DetectionHPLC-ECOxidizable NeurotransmittersMetabolitesDrug IntroductionSite SpecificityMechanism Of ActionAnatomical ResolutionChemical ResolutionTime ResolutionMicrodialysis SamplesDetectable Neurotransmitter LevelsEx Vivo ToolsSlice And Cell Culture Electrophysiology
