/
/
A Microfluidic Model of Biomimetically Breathing Pulmonary Acinar Airways
A subscription to JoVE is required to view this content. Sign in or start your free trial.
Chapters
- 00:05Title
- 00:54Preparation of the Microfluidic Device
- 04:30Device Filling and Actuation
- 06:21Micro-particle Image Velocimetry
- 07:45Results: Imaging of Physiologically Realistic Flow Profiles
- 09:02Conclusion
Soft-lithography was utilized to produce a representative true-scale model of pulmonary alveolated airways that expand and contract periodically, mimicking physiological breathing motion. This platform recreates respiratory acinar flows on a chip, and is anticipated to facilitate experimental investigation of inhaled aerosol dynamics and deposition in the pulmonary acinus.
