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Minimally Invasive Transverse Aortic Constriction in Mice
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Minimally Invasive Transverse Aortic Constriction in Mice

Minimally Invasive Transverse Aortic Constriction in Mice

DOI:
10.3791/55293-v

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07:40 min

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March 14, 2017

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, , ,
1School of Biological Sciences,The University of Hong Kong, 2College of Arts and Science,New York University, 3Department of Health Technology and Informatics, Faculty of Health and Social Sciences,The Hong Kong Polytechnic University

Chapters

  • 00:05Title
  • 00:44Surgical Preparation
  • 01:46Minimally Invasive Transverse Aortic Constriction (MTAC)
  • 03:50Echocardiography: Successful Ligation Confirmation and Measurement
  • 05:27Results: Representative Vessel Imaging
  • 06:51Conclusion

Summary

Automatic Translation

Automatic Translation

Minimally invasive transverse aortic constriction (MTAC) conserves the essentials of regular transverse aortic constriction (TAC) while eliminating the use of a ventilator with tracheal intubation. It proves to be a highly desirable method for high-throughput studies on left ventricular overload, particularly in translational studies.

Tags

Minimally InvasiveTransverse Aortic ConstrictionMiceLeft Ventricular HypertrophyMyocardial RemodelingCardiac HypertrophyApoptosisFibrosisLeft Ventricular Pressure OverloadSurgical ProcedureTransverse Aortic Arch30-gauge Needles27-gauge Needle0.4 Millimeter SpacerSedationHeating PadMidline IncisionBlunt DissectionThyroid GlandSternumThymus LobesTransverse Aortic ArchCarotid Arteries6-0 Monofilament Suture

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