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JoVE Journal Developmental Biology
Assessment of Ultrastructural Neuroplasticity Parameters After In Utero Transduction of the Developing Mouse Brain and Spinal Cord
 

Assessment of Ultrastructural Neuroplasticity Parameters After In Utero Transduction of the Developing Mouse Brain and Spinal Cord

Article DOI: 10.3791/59084-v • 10:28 min • February 26th, 2019
February 26th, 2019 •
*1, *1, 1, 1, 1, 2, 1
1Department of Neuroanatomy and Molecular Brain Research, Ruhr University Bochum, 2Central Animal Facility of the Medical Faculty, Ruhr University Bochum
* These authors contributed equally

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Summary
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The combination of transmission electron microscopy and in utero transduction is a powerful approach for studying morphological changes in the fine ultrastructure of the nervous system during development. This combined method allows deep insights into changes in structural details underlying neuroplasticity with respect to their topographical representation.

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Keywords: Ultrastructural Neuroplasticity In Utero Transduction Mouse Brain Spinal Cord Congenital Neurodegenerative Diseases Adeno-associated Virus Embryonic Development Tissue Preparation Electron Microscopy
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