Jacques Lapointe Department of Surgery, Division of Urology McGill University Biography Publications Institution JoVE Articles Jacques Lapointe has not added a biography. If you are Jacques Lapointe and would like to personalize this page please email our Author Liaison for assistance. Publications Interference Between Surgical Magnetic Drapes and Pacemakers: an Observational Study Comparing Commercially Available Devices and a New Magnetically Isolated Drape Biomedical Engineering Online. 2016 | Pubmed ID: 27430339 Cyclic Peptides Identified by Phage Display Are Competitive Inhibitors of the TRNA-dependent Amidotransferase of Helicobacter Pylori Peptides. May, 2016 | Pubmed ID: 26976271 Correction: TRNAGlu Increases the Affinity of Glutamyl-tRNA Synthetase for Its Inhibitor Glutamyl-Sulfamoyl-Adenosine, an Analogue of the Aminoacylation Reaction Intermediate Glutamyl-AMP: Mechanistic and Evolutionary Implications PloS One. 2015 | Pubmed ID: 26039673 TRNAGlu Increases the Affinity of Glutamyl-tRNA Synthetase for Its Inhibitor Glutamyl-sulfamoyl-adenosine, an Analogue of the Aminoacylation Reaction Intermediate Glutamyl-AMP: Mechanistic and Evolutionary Implications PloS One. 2015 | Pubmed ID: 25860020 Magnetic Interference of Cardiac Pacemakers from a Surgical Magnetic Drape Anesthesia and Analgesia. Mar, 2013 | Pubmed ID: 23400981 The 16p13.3 (PDPK1) Genomic Gain in Prostate Cancer: A Potential Role in Disease Progression Translational Oncology. Dec, 2012 | Pubmed ID: 23401739 PTEN Genomic Deletion Predicts Prostate Cancer Recurrence and is Associated with Low AR Expression and Transcriptional Activity BMC Cancer. 2012 | Pubmed ID: 23171135 Natural Insertion of the Bro-1 β-lactamase Gene into the GatCAB Operon Affects Moraxella Catarrhalis Aspartyl-tRNA(Asn) Amidotransferase Activity Microbiology (Reading, England). Sep, 2012 | Pubmed ID: 22745266 The Asparagine-transamidosome from Helicobacter Pylori: a Dual-kinetic Mode in Non-discriminating Aspartyl-tRNA Synthetase Safeguards the Genetic Code Nucleic Acids Research. Jun, 2012 | Pubmed ID: 22362756 Gln-tRNAGln Synthesis in a Dynamic Transamidosome from Helicobacter Pylori, Where GluRS2 Hydrolyzes Excess Glu-tRNAGln Nucleic Acids Research. Nov, 2011 | Pubmed ID: 21813455 A Tri-marker Proliferation Index Predicts Biochemical Recurrence After Surgery for Prostate Cancer PloS One. 2011 | Pubmed ID: 21629784 Inhibition of Helicobacter Pylori Aminoacyl-tRNA Amidotransferase by Chloramphenicol Analogs Bioorganic & Medicinal Chemistry. Nov, 2010 | Pubmed ID: 20943400 A C-truncated Glutamyl-tRNA Synthetase Specific for TRNA(Glu) is Stimulated by Its Free Complementary Distal Domain: Mechanistic and Evolutionary Implications Biochemistry. Jun, 2009 | Pubmed ID: 19496540 Peculiar Inhibition of Human Mitochondrial Aspartyl-tRNA Synthetase by Adenylate Analogs Biochimie. May, 2009 | Pubmed ID: 19254750 Identification of Candidate Prostate Cancer Genes Through Comparative Expression-profiling of Seminal Vesicle The Prostate. Aug, 2008 | Pubmed ID: 18500686 Inhibition of Helicobacter Pylori Aminoacyl-tRNA Amidotransferase by Puromycin Analogues Journal of the American Chemical Society. Mar, 2008 | Pubmed ID: 18293984 HCAP-D3 Expression Marks a Prostate Cancer Subtype with Favorable Clinical Behavior and Androgen Signaling Signature The American Journal of Surgical Pathology. Feb, 2008 | Pubmed ID: 18223322 Mechanism of a GatCAB Amidotransferase: Aspartyl-tRNA Synthetase Increases Its Affinity for Asp-tRNA(Asn) and Novel Aminoacyl-tRNA Analogues Are Competitive Inhibitors Biochemistry. Nov, 2007 | Pubmed ID: 17929881 Genomic Profiling Reveals Alternative Genetic Pathways of Prostate Tumorigenesis Cancer Research. Sep, 2007 | Pubmed ID: 17875689 E. Coli Glutamyl-tRNA Synthetase is Inhibited by Anticodon Stem-loop Domains and a Minihelix RNA Biology. Jul, 2007 | Pubmed ID: 17671438 Inhibition by L-aspartol Adenylate of a Nondiscriminating Aspartyl-tRNA Synthetase Reveals Differences Between the Interactions of Its Active Site with TRNA(Asp) and TRNA(Asn) Journal of Enzyme Inhibition and Medicinal Chemistry. Feb, 2007 | Pubmed ID: 17373551 A Variant TMPRSS2 Isoform and ERG Fusion Product in Prostate Cancer with Implications for Molecular Diagnosis Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Apr, 2007 | Pubmed ID: 17334351 Synthesis of Beta-ketophosphonate Analogs of Glutamyl and Glutaminyl Adenylate, and Selective Inhibition of the Corresponding Bacterial Aminoacyl-tRNA Synthetases Bioorganic & Medicinal Chemistry. Jan, 2007 | Pubmed ID: 17049867 Structural Bases of Transfer RNA-dependent Amino Acid Recognition and Activation by Glutamyl-tRNA Synthetase Structure (London, England : 1993). Dec, 2006 | Pubmed ID: 17161369 Application of Genomic Technologies to Human Prostate Cancer Omics : a Journal of Integrative Biology. 2006 | Pubmed ID: 17069507 Two Residues in the Anticodon Recognition Domain of the Aspartyl-tRNA Synthetase from Pseudomonas Aeruginosa Are Individually Implicated in the Recognition of TRNAAsn Journal of Bacteriology. Jan, 2006 | Pubmed ID: 16352843 The Retinoic Acid Synthesis Gene ALDH1a2 is a Candidate Tumor Suppressor in Prostate Cancer Cancer Research. Sep, 2005 | Pubmed ID: 16166285 Glu-Q-tRNA(Asp) Synthetase Coded by the YadB Gene, a New Paralog of Aminoacyl-tRNA Synthetase That Glutamylates TRNA(Asp) Anticodon Biochimie. Sep-Oct, 2005 | Pubmed ID: 16164993 Glutamylsulfamoyladenosine and Pyroglutamylsulfamoyladenosine Are Competitive Inhibitors of E. Coli Glutamyl-tRNA Synthetase Journal of Enzyme Inhibition and Medicinal Chemistry. Feb, 2005 | Pubmed ID: 15895686 Synthesis and Aminoacyl-tRNA Synthetase Inhibitory Activity of Aspartyl Adenylate Analogs Bioorganic & Medicinal Chemistry. Jan, 2005 | Pubmed ID: 15582453 Genome-wide Characterization of Gene Expression Variations and DNA Copy Number Changes in Prostate Cancer Cell Lines The Prostate. May, 2005 | Pubmed ID: 15486987 Crystal Structure of Chloramphenicol Acetyltransferase B2 Encoded by the Multiresistance Transposon Tn2424 Proteins. Dec, 2004 | Pubmed ID: 15390264 A Minimalist Glutamyl-tRNA Synthetase Dedicated to Aminoacylation of the TRNAAsp QUC Anticodon Nucleic Acids Research. 2004 | Pubmed ID: 15150343 An Aminoacyl-tRNA Synthetase-like Protein Encoded by the Escherichia Coli YadB Gene Glutamylates Specifically TRNAAsp Proceedings of the National Academy of Sciences of the United States of America. May, 2004 | Pubmed ID: 15096594 The Escherichia Coli YadB Gene Product Reveals a Novel Aminoacyl-tRNA Synthetase Like Activity Journal of Molecular Biology. Mar, 2004 | Pubmed ID: 15003446 The Zinc-binding Site of a Class I Aminoacyl-tRNA Synthetase is a SWIM Domain That Modulates Amino Acid Binding Via the TRNA Acceptor Arm European Journal of Biochemistry / FEBS. Feb, 2004 | Pubmed ID: 14764088 Direct Glutaminyl-tRNA Biosynthesis and Indirect Asparaginyl-tRNA Biosynthesis in Pseudomonas Aeruginosa PAO1 Journal of Bacteriology. Feb, 2004 | Pubmed ID: 14729703 Gene Expression Profiling Identifies Clinically Relevant Subtypes of Prostate Cancer Proceedings of the National Academy of Sciences of the United States of America. Jan, 2004 | Pubmed ID: 14711987 ATP Binding by Glutamyl-tRNA Synthetase is Switched to the Productive Mode by TRNA Binding The EMBO Journal. Feb, 2003 | Pubmed ID: 12554668 Preparation of Formalin-fixed Paraffin-embedded Tissue Cores for both RNA and DNA Extraction Palak G. Patel1,2, Shamini Selvarajah1,2, Suzanne Boursalie1,2, Nathan E. How1,2, Joshua Ejdelman3, Karl-Philippe Guerard3, John M. Bartlett4, Jacques Lapointe3, Paul C. Park1, John B. A. Okello1,2, David M. Berman1,2 1Department of Pathology & Molecular Medicine, Queen's University, 2Division of Cancer Biology & Genetics, Queen's Cancer Research Institute, Queen's University, 3Department of Surgery, Division of Urology, McGill University, 4Transformative Pathology Program, Ontario Institute for Cancer Research (OICR) JoVE 54299 Biology
Preparation of Formalin-fixed Paraffin-embedded Tissue Cores for both RNA and DNA Extraction Palak G. Patel1,2, Shamini Selvarajah1,2, Suzanne Boursalie1,2, Nathan E. How1,2, Joshua Ejdelman3, Karl-Philippe Guerard3, John M. Bartlett4, Jacques Lapointe3, Paul C. Park1, John B. A. Okello1,2, David M. Berman1,2 1Department of Pathology & Molecular Medicine, Queen's University, 2Division of Cancer Biology & Genetics, Queen's Cancer Research Institute, Queen's University, 3Department of Surgery, Division of Urology, McGill University, 4Transformative Pathology Program, Ontario Institute for Cancer Research (OICR) JoVE 54299 Biology