Vassiliki A. Boussiotis Division of Hematology-Oncology, Beth Israel Deaconess Medical Center Harvard Medical School Biography Publications Institution JoVE Articles Vassiliki A. Boussiotis has not added a biography. If you are Vassiliki A. Boussiotis and would like to personalize this page please email our Author Liaison for assistance. Publications Targeting T Cell Metabolism for Improvement of Cancer Immunotherapy Frontiers in Oncology. Month, 2018 | Pubmed ID: 30123774 Publisher Correction: Feeling Stressed? It Might Be Your T Cells Nature Immunology. Sep, 2018 | Pubmed ID: 29955108 Possible Reactivation of Chromosomally Integrated Human Herpesvirus 6 After Treatment with Histone Deacetylase Inhibitor Blood Advances. Jun, 2018 | Pubmed ID: 29898877 Immunotherapies for Malignant Glioma Oncogene. Mar, 2018 | Pubmed ID: 29242608 Feeling Stressed? It Might Be Your T Cells Nature Immunology. Nov, 2017 | Pubmed ID: 29144505 The Adaptor Molecule RIAM Integrates Signaling Events Critical for Integrin-mediated Control of Immune Function and Cancer Progression Science Signaling. Aug, 2017 | Pubmed ID: 28831022 Advances in the Pathophysiology and Treatment of Relapsed/refractory Hodgkin's Lymphoma with an Emphasis on Targeted Therapies and Transplantation Strategies Blood and Lymphatic Cancer : Targets and Therapy. Month, 2017 | Pubmed ID: 28701859 Immunometabolic Regulations Mediated by Coinhibitory Receptors and Their Impact on T Cell Immune Responses Frontiers in Immunology. Month, 2017 | Pubmed ID: 28443090 Angiogenic Factors Correlate with T Cell Immune Reconstitution and Clinical Outcomes After Double-Unit Umbilical Cord Blood Transplantation in Adults Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation. 01, 2017 | Pubmed ID: 27777141 JAK3-mediated Phosphorylation of EZH2: a Novel Mechanism of Non-canonical EZH2 Activation and Oncogenic Function Translational Cancer Research. Nov, 2016 | Pubmed ID: 28868240 The Role of Metabolic Reprogramming in T Cell Fate and Function Current Trends in Immunology. Month, 2016 | Pubmed ID: 28356677 The PD1:PD-L1/2 Pathway from Discovery to Clinical Implementation Frontiers in Immunology. Month, 2016 | Pubmed ID: 28018338 Epigenetic Regulation of Cancer Biology and Anti-tumor Immunity by EZH2 Oncotarget. Dec, 2016 | Pubmed ID: 27793053 Corrigendum: Regulation of T Cell Differentiation and Function by EZH2 Frontiers in Immunology. Month, 2016 | Pubmed ID: 27648006 Clinical Significance of T Cell Metabolic Reprogramming in Cancer Clinical and Translational Medicine. Dec, 2016 | Pubmed ID: 27510264 Regulation of T Cell Differentiation and Function by EZH2 Frontiers in Immunology. Month, 2016 | Pubmed ID: 27199994 Cell-specific PD-L1 Expression in DLBCL Blood. Nov, 2015 | Pubmed ID: 26542250 PD-1 Alters T-cell Metabolic Reprogramming by Inhibiting Glycolysis and Promoting Lipolysis and Fatty Acid Oxidation Nature Communications. Mar, 2015 | Pubmed ID: 25809635 Somatic Mutations and Immunotherapy Outcome with CTLA-4 Blockade in Melanoma The New England Journal of Medicine. Dec, 2014 | Pubmed ID: 25409261 The Role of the Thymus in T-cell Immune Reconstitution After Umbilical Cord Blood Transplantation Blood. Nov, 2014 | Pubmed ID: 25287708 Biochemical Signaling of PD-1 on T Cells and Its Functional Implications Cancer Journal (Sudbury, Mass.). Jul-Aug, 2014 | Pubmed ID: 25098287 The Cyclin Dependent Kinase Inhibitor (R)-roscovitine Mediates Selective Suppression of Alloreactive Human T Cells but Preserves Pathogen-specific and Leukemia-specific Effectors Clinical Immunology (Orlando, Fla.). May-Jun, 2014 | Pubmed ID: 24631965 The Role of IL-17-producing Foxp3+ CD4+ T Cells in Inflammatory Bowel Disease and Colon Cancer Clinical Immunology (Orlando, Fla.). Aug, 2013 | Pubmed ID: 23773923 PD-1 Increases PTEN Phosphatase Activity While Decreasing PTEN Protein Stability by Inhibiting Casein Kinase 2 Molecular and Cellular Biology. Aug, 2013 | Pubmed ID: 23732914 RIAM (Rap1-interacting Adaptor Molecule) Regulates Complement-dependent Phagocytosis Cellular and Molecular Life Sciences : CMLS. Jul, 2013 | Pubmed ID: 23420480 Rap1-interacting Adapter Molecule (RIAM) Associates with the Plasma Membrane Via a Proximity Detector The Journal of Cell Biology. Oct, 2012 | Pubmed ID: 23045549 PD-1 Inhibits T Cell Proliferation by Upregulating P27 and P15 and Suppressing Cdc25A Cell Cycle (Georgetown, Tex.). Dec, 2012 | Pubmed ID: 23032366 Runx1 and Runx3 Are Involved in the Generation and Function of Highly Suppressive IL-17-producing T Regulatory Cells PloS One. Month, 2012 | Pubmed ID: 22984619 Selective Effects of PD-1 on Akt and Ras Pathways Regulate Molecular Components of the Cell Cycle and Inhibit T Cell Proliferation Science Signaling. Jun, 2012 | Pubmed ID: 22740686 Molecular and Functional Heterogeneity of T Regulatory Cells Clinical Immunology (Orlando, Fla.). Dec, 2011 | Pubmed ID: 21945485 Rap1-GTP-interacting Adaptor Molecule (RIAM) Protein Controls Invasion and Growth of Melanoma Cells The Journal of Biological Chemistry. May, 2011 | Pubmed ID: 21454517 Rap1A Regulates Generation of T Regulatory Cells Via LFA-1-dependent and LFA-1-independent Mechanisms Cellular Immunology. Month, 2010 | Pubmed ID: 20864093 IL-1β-mediated Signals Preferentially Drive Conversion of Regulatory T Cells but Not Conventional T Cells into IL-17-producing Cells Journal of Immunology (Baltimore, Md. : 1950). Oct, 2010 | Pubmed ID: 20817874 RIAM Regulates the Cytoskeletal Distribution and Activation of PLC-gamma1 in T Cells Science Signaling. Dec, 2009 | Pubmed ID: 19952372 The Cyclin Dependent Kinase Inhibitor (R)-roscovitine Prevents Alloreactive T Cell Clonal Expansion and Protects Against Acute GvHD Cell Cycle (Georgetown, Tex.). Jun, 2009 | Pubmed ID: 19448431 Tob, a Member of the APRO Family, Regulates Immunological Quiescence and Tumor Suppression Cell Cycle (Georgetown, Tex.). Apr, 2009 | Pubmed ID: 19270514 Interleukin-4 Stimulates Proliferation and Growth of T-cell Acute Lymphoblastic Leukemia Cells by Activating MTOR Signaling Leukemia. Jan, 2009 | Pubmed ID: 18596736 The Nore1B/Mst1 Complex Restrains Antigen Receptor-induced Proliferation of Naïve T Cells Proceedings of the National Academy of Sciences of the United States of America. Dec, 2008 | Pubmed ID: 19073936 Control and Regulation of Peripheral Tolerance in Allergic Inflammatory Disease: Therapeutic Consequences Chemical Immunology and Allergy. Month, 2008 | Pubmed ID: 18802347 CD134-allodepletion Allows Selective Elimination of Alloreactive Human T Cells Without Loss of Virus-specific and Leukemia-specific Effectors Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation. May, 2008 | Pubmed ID: 18410894 Umbilical Cord Blood Transplantation: Basic Biology and Clinical Challenges to Immune Reconstitution Clinical Immunology (Orlando, Fla.). Jun, 2008 | Pubmed ID: 18395491 Twisted Gastrulation (Tsg) is Regulated by Tob and Enhances TGF-beta Signaling in Activated T Lymphocytes Blood. Apr, 2007 | Pubmed ID: 17164348 A Pathway Regulated by Cell Cycle Inhibitor P27Kip1 and Checkpoint Inhibitor Smad3 is Involved in the Induction of T Cell Tolerance Nature Immunology. Nov, 2006 | Pubmed ID: 17013388 Physiologic Regulation of Central and Peripheral T Cell Tolerance: Lessons for Therapeutic Applications Journal of Molecular Medicine (Berlin, Germany). Nov, 2006 | Pubmed ID: 16972086 CD28 Costimulation Mediates Transcription of SKP2 and CKS1, the Substrate Recognition Components of SCFSkp2 Ubiquitin Ligase That Leads P27kip1 to Degradation Cell Cycle (Georgetown, Tex.). Sep, 2006 | Pubmed ID: 16969077 Rap1 Regulation of RIAM and Cell Adhesion Methods in Enzymology. Month, 2006 | Pubmed ID: 16757337 Rap1-GTP is a Negative Regulator of Th Cell Function and Promotes the Generation of CD4+CD103+ Regulatory T Cells in Vivo Journal of Immunology (Baltimore, Md. : 1950). Sep, 2005 | Pubmed ID: 16116203 CD4+CD25+ Regulatory T-cell Lines from Human Cord Blood Have Functional and Molecular Properties of T-cell Anergy Blood. Nov, 2005 | Pubmed ID: 16020508 Common Gamma Chain-signaling Cytokines Promote Proliferation of T-cell Acute Lymphoblastic Leukemia Haematologica. Dec, 2004 | Pubmed ID: 15590396 RIAM, an Ena/VASP and Profilin Ligand, Interacts with Rap1-GTP and Mediates Rap1-induced Adhesion Developmental Cell. Oct, 2004 | Pubmed ID: 15469846 Activation of PI3K is Indispensable for Interleukin 7-mediated Viability, Proliferation, Glucose Use, and Growth of T Cell Acute Lymphoblastic Leukemia Cells The Journal of Experimental Medicine. Sep, 2004 | Pubmed ID: 15353558 IL-7-dependent Human Leukemia T-cell Line As a Valuable Tool for Drug Discovery in T-ALL Blood. Mar, 2004 | Pubmed ID: 14615384 Antigen-specific and Persistent Tuberculin Anergy in a Cohort of Pulmonary Tuberculosis Patients from Rural Cambodia Proceedings of the National Academy of Sciences of the United States of America. May, 2002 | Pubmed ID: 12032325 CD28 Costimulation Mediates Down-regulation of P27kip1 and Cell Cycle Progression by Activation of the PI3K/PKB Signaling Pathway in Primary Human T Cells Journal of Immunology (Baltimore, Md. : 1950). Mar, 2002 | Pubmed ID: 11884439 Blockade of B7/CD28 in Mixed Lymphocyte Reaction Cultures Results in the Generation of Alternatively Activated Macrophages, Which Suppress T-cell Responses Blood. Feb, 2002 | Pubmed ID: 11830501 CTLA-4 Regulates Cell Cycle Progression During a Primary Immune Response European Journal of Immunology. 02, 2002 | Pubmed ID: 11807776 Unraveling Key Players of Humoral Immunity: Advanced and Optimized Lymphocyte Isolation Protocol from Murine Peyer's Patches Yavuz F. Yazicioglu1,2, Halil I. Aksoylar1,2, Rinku Pal1,2, Nikolaos Patsoukis1,2, Vassiliki A. Boussiotis1,2 1Division of Hematology-Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, 2Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School JoVE 58490 Cancer Research
Unraveling Key Players of Humoral Immunity: Advanced and Optimized Lymphocyte Isolation Protocol from Murine Peyer's Patches Yavuz F. Yazicioglu1,2, Halil I. Aksoylar1,2, Rinku Pal1,2, Nikolaos Patsoukis1,2, Vassiliki A. Boussiotis1,2 1Division of Hematology-Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, 2Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School JoVE 58490 Cancer Research