Benjamin Combs Department of Translational Neuroscience, College of Human Medicine Michigan State University Biography Publications Institution JoVE Articles Benjamin Combs has not added a biography. If you are Benjamin Combs and would like to personalize this page please email our Author Liaison for assistance. Publications Phosphomimetics at Ser199/Ser202/Thr205 in Tau Impairs Axonal Transport in Rat Hippocampal Neurons Molecular Neurobiology. Jun, 2023 | Pubmed ID: 36859689 Age-dependent Accumulation of Tau Aggregation in Frontiers in Aging. 2022 | Pubmed ID: 36062211 Frontotemporal Lobar Dementia Mutant Tau Impairs Axonal Transport Through a Protein Phosphatase 1γ-Dependent Mechanism The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2021 | Pubmed ID: 34607969 Tau: A Signaling Hub Protein Frontiers in Molecular Neuroscience. 2021 | Pubmed ID: 33815057 Liquid-liquid Phase Separation Induces Pathogenic Tau Conformations in Vitro Nature Communications. Jun, 2020 | Pubmed ID: 32499559 Tau and Axonal Transport Misregulation in Tauopathies Advances in Experimental Medicine and Biology. 2019 | Pubmed ID: 32096030 FTDP-17 Mutations Alter the Aggregation and Microtubule Stabilization Propensity of Tau in an Isoform-Specific Fashion Biochemistry. Feb, 2019 | Pubmed ID: 30562452 Axonal Degeneration in Tauopathies: Disease Relevance and Underlying Mechanisms Frontiers in Neuroscience. 2017 | Pubmed ID: 29089864 Production of Recombinant Tau Oligomers in Vitro Methods in Cell Biology. 2017 | Pubmed ID: 28882311 Exposure of the Amino Terminus of Tau Is a Pathological Event in Multiple Tauopathies The American Journal of Pathology. Jun, 2017 | Pubmed ID: 28413156 Analysis of Isoform-specific Tau Aggregates Suggests a Common Toxic Mechanism Involving Similar Pathological Conformations and Axonal Transport Inhibition Neurobiology of Aging. 11, 2016 | Pubmed ID: 27574109 Pseudophosphorylation of Tau at S422 Enhances SDS-stable Dimer Formation and Impairs Both Anterograde and Retrograde Fast Axonal Transport Experimental Neurology. Sep, 2016 | Pubmed ID: 27373205 Pathological Conformations Involving the Amino Terminus of Tau Occur Early in Alzheimer's Disease and Are Differentially Detected by Monoclonal Antibodies Neurobiology of Disease. Oct, 2016 | Pubmed ID: 27260838 Gene Therapy Models of Alzheimer's Disease and Other Dementias Methods in Molecular Biology (Clifton, N.J.). 2016 | Pubmed ID: 26611599 Heat Shock Protein 70 Prevents Both Tau Aggregation and the Inhibitory Effects of Preexisting Tau Aggregates on Fast Axonal Transport Biochemistry. Nov, 2011 | Pubmed ID: 22039833 Using Live-Cell Imaging to Measure the Effects of Pathological Proteins on Axonal Transport in Primary Hippocampal Neurons Rebecca L. Mueller1,2, Nicholas M. Kanaan1,2,3, Benjamin Combs1 1Department of Translational Neuroscience, College of Human Medicine, Michigan State University, 2Neuroscience Program, Michigan State University, 3Hauenstein Neuroscience Center, Mercy Health Saint Mary’s JoVE 66156 Neuroscience
Using Live-Cell Imaging to Measure the Effects of Pathological Proteins on Axonal Transport in Primary Hippocampal Neurons Rebecca L. Mueller1,2, Nicholas M. Kanaan1,2,3, Benjamin Combs1 1Department of Translational Neuroscience, College of Human Medicine, Michigan State University, 2Neuroscience Program, Michigan State University, 3Hauenstein Neuroscience Center, Mercy Health Saint Mary’s JoVE 66156 Neuroscience
