Brandon J. Biesiadecki

Department of Physiology and Cell Biology, The Ohio State University

Affiliated withThe Ohio State University

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 1	2022

Other Publications

Article	Year
Increased phosphorylation of tropomyosin, troponin I, and myosin light chain-2 after stretch in rabbit ventricular myocardium under physiological conditions. Journal of molecular and cellular cardiology\| PubMed ID: 20298699	2010
A high-throughput solid-phase microplate protein-binding assay to investigate interactions between myofilament proteins. Journal of biomedicine & biotechnology\| PubMed ID: 22190850	2011
Effects of increased preload on the force-frequency response and contractile kinetics in early stages of cardiac muscle hypertrophy. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 22467304	2012
AMP-activated protein kinase phosphorylates cardiac troponin I at Ser-150 to increase myofilament calcium sensitivity and blunt PKA-dependent function. The Journal of biological chemistry\| PubMed ID: 22493448	2012
Engineered troponin C constructs correct disease-related cardiac myofilament calcium sensitivity. The Journal of biological chemistry\| PubMed ID: 22511780	2012
Staurosporine inhibits frequency-dependent myofilament desensitization in intact rabbit cardiac trabeculae. Biochemistry research international\| PubMed ID: 22649731	2012
The rates of Ca2+ dissociation and cross-bridge detachment from ventricular myofibrils as reported by a fluorescent cardiac troponin C. The Journal of biological chemistry\| PubMed ID: 22718768	2012
Advanced glycation end product cross-link breaker attenuates diabetes-induced cardiac dysfunction by improving sarcoplasmic reticulum calcium handling. Frontiers in physiology\| PubMed ID: 22934044	2012
Effects of increased systolic Ca(2+) and β-adrenergic stimulation on Ca(2+) transient decline in NOS1 knockout cardiac myocytes. Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society\| PubMed ID: 22960389	2012
Tropomyosin Ser-283 pseudo-phosphorylation slows myofibril relaxation. Archives of biochemistry and biophysics\| PubMed ID: 23232082	2013
Ryanodine receptor phosphorylation by oxidized CaMKII contributes to the cardiotoxic effects of cardiac glycosides. Cardiovascular research\| PubMed ID: 24104877	2014
Protein kinase C phosphomimetics alter thin filament Ca2+ binding properties. PloS one\| PubMed ID: 24466001	2014
Desensitization of myofilaments to Ca2+ as a therapeutic target for hypertrophic cardiomyopathy with mutations in thin filament proteins. Circulation. Cardiovascular genetics\| PubMed ID: 24585742	2014
Combined troponin I Ser-150 and Ser-23/24 phosphorylation sustains thin filament Ca(2+) sensitivity and accelerates deactivation in an acidic environment. Journal of molecular and cellular cardiology\| PubMed ID: 24657721	2014
Upregulation of adenosine A1 receptors facilitates sinoatrial node dysfunction in chronic canine heart failure by exacerbating nodal conduction abnormalities revealed by novel dual-sided int... Circulation\| PubMed ID: 24838362	2014
Cardiac troponin I tyrosine 26 phosphorylation decreases myofilament Ca2+ sensitivity and accelerates deactivation. Journal of molecular and cellular cardiology\| PubMed ID: 25252176	2014
Obligatory role of neuronal nitric oxide synthase in the heart's antioxidant adaptation with exercise. Journal of molecular and cellular cardiology\| PubMed ID: 25595735	2015
Dissociation of Calcium Transients and Force Development following a Change in Stimulation Frequency in Isolated Rabbit Myocardium. BioMed research international\| PubMed ID: 25961020	2015
Protein phosphatase 2A regulatory subunit B56α limits phosphatase activity in the heart. Science signaling\| PubMed ID: 26198358
Molecular Mapping of Sinoatrial Node HCN Channel Expression in the Human Heart. Circulation. Arrhythmia and electrophysiology\| PubMed ID: 26304511	2015
Nucleotide and protein sequences for dog masticatory tropomyosin identify a novel Tpm4 gene product. Journal of muscle research and cell motility\| PubMed ID: 26400443	2015
Should we treat heart failure with phosphatase inhibitors? Better to start at the end. Journal of molecular and cellular cardiology\| PubMed ID: 26497613	2015
Rationally engineered Troponin C modulates in vivo cardiac function and performance in health and disease. Nature communications\| PubMed ID: 26908229	2016
Myofilament modulation of contraction. Archives of biochemistry and biophysics\| PubMed ID: 27156968	2016
The Need for Speed: Mice, Men, and Myocardial Kinetic Reserve. Circulation research\| PubMed ID: 27458197	2016
Adenosine-Induced Atrial Fibrillation: Localized Reentrant Drivers in Lateral Right Atria due to Heterogeneous Expression of Adenosine A1 Receptors and GIRK4 Subunits in the Human Heart. Circulation\| PubMed ID: 27462069	2016
Myofilament Calcium Sensitivity: Role in Regulation of Cardiac Contraction and Relaxation. Frontiers in physiology\| PubMed ID: 28018228	2016
Myofilament Calcium Sensitivity: Consequences of the Effective Concentration of Troponin I. Frontiers in physiology\| PubMed ID: 28066265	2016
Tri-modal regulation of cardiac muscle relaxation; intracellular calcium decline, thin filament deactivation, and cross-bridge cycling kinetics. Biophysical reviews\| PubMed ID: 28510030	2014
Functional communication between PKC-targeted cardiac troponin I phosphorylation sites. Archives of biochemistry and biophysics\| PubMed ID: 28587770	2017
Secondary phosphorylation in myocytes expressing FLAG-tagged and non-tagged phospho-mimetic cardiac troponin I. Data in brief\| PubMed ID: 29071293	2017
Assessment of PKA and PKC inhibitors on force and kinetics of non-failing and failing human myocardium. Life sciences\| PubMed ID: 30399377	2018
3-Chlorodiphenylamine activates cardiac troponin by a mechanism distinct from bepridil or TFP. The Journal of general physiology\| PubMed ID: 30442775	2019
Troponin I modulation of cardiac performance: Plasticity in the survival switch. Archives of biochemistry and biophysics\| PubMed ID: 30684464	2019
Current and Future Directions of Myofilament Regulation. Archives of biochemistry and biophysics\| PubMed ID: 31051122	2019
Impaired neuronal sodium channels cause intranodal conduction failure and reentrant arrhythmias in human sinoatrial node. Nature communications\| PubMed ID: 31980605	2020
Site-specific acetyl-mimetic modification of cardiac troponin I modulates myofilament relaxation and calcium sensitivity. Journal of molecular and cellular cardiology\| PubMed ID: 31981571	2020
mutations in the tropomyosin binding region of TNT1 disrupt its role in contractile inhibition and stimulate cardiac dysfunction. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 32690703	2020
Heart Failure in Humans Reduces Contractile Force in Myocardium From Both Ventricles. JACC. Basic to translational science\| PubMed ID: 32875169	2020
Post-translational modification patterns on β-myosin heavy chain are altered in ischemic and nonischemic human hearts. eLife\| PubMed ID: 35502901	2022