Chien-Kuo Lee Graduate Institute of Immunology National Taiwan University Biography Publications Institution JoVE Articles Chien-Kuo Lee Chien-Kuo Lee is a Professor in the Graduate Institute of Immunology, National Taiwan University College of Medicine. He received a Ph.D. degree in 1998 at New York University School of Medicine, USA.Dr. Lee did his postdoctoral trainings at NYUSM and National Institute for Medical Research, UK (1998-2002). He has been interested in cytokine signal transduction and unveiling the roles of type I IFN and its downstream signal mediators, particularly STAT1 and STAT3, in immunomodulation, including dendritic cell development and functions, B cell differentiation and antiviral response. Publications Efficient Generation of Plasmacytoid Dendritic Cell from Common Lymphoid Progenitors by Flt3 Ligand PloS One. Month, 2015 | Pubmed ID: 26263178 An Alternatively Spliced IL-15 Isoform Modulates Abrasion-induced Keratinocyte Activation The Journal of Investigative Dermatology. May, 2015 | Pubmed ID: 25615554 STAT2/IRF9 Directs a Prolonged ISGF3-like Transcriptional Response and Antiviral Activity in the Absence of STAT1 The Biochemical Journal. Mar, 2015 | Pubmed ID: 25564224 Effects of RING-SH2Grb², a Chimeric Protein Containing the E3 Ligase Domain of Cbl, on the EGFR Pathway The Chinese Journal of Physiology. Dec, 2014 | Pubmed ID: 25575524 The Pathological Effects of CCR2+ Inflammatory Monocytes Are Amplified by an IFNAR1-triggered Chemokine Feedback Loop in Highly Pathogenic Influenza Infection Journal of Biomedical Science. Month, 2014 | Pubmed ID: 25407417 Immunodeficient Mouse Models with Different Disease Profiles by in Vivo Infection with the Same Clinical Isolate of Enterovirus 71 Journal of Virology. Nov, 2014 | Pubmed ID: 25142603 A Type I IFN-Flt3 Ligand Axis Augments Plasmacytoid Dendritic Cell Development from Common Lymphoid Progenitors The Journal of Experimental Medicine. Nov, 2013 | Pubmed ID: 24145513 Intrahepatic Infiltrating NK and CD8 T Cells Cause Liver Cell Death in Different Phases of Dengue Virus Infection PloS One. Month, 2012 | Pubmed ID: 23050007 STAT3 Negatively Regulates Type I IFN-mediated Antiviral Response Journal of Immunology (Baltimore, Md. : 1950). Sep, 2011 | Pubmed ID: 21810606 Suppressor of Cytokine Signaling and Accelerated Atherosclerosis in Kidney Disease Acta Biochimica Polonica. Month, 2010 | Pubmed ID: 20725646 STAT2 Hypomorphic Mutant Mice Display Impaired Dendritic Cell Development and Antiviral Response Journal of Biomedical Science. Month, 2009 | Pubmed ID: 19272190 CLEC5A is Critical for Dengue-virus-induced Lethal Disease Nature. May, 2008 | Pubmed ID: 18496526 Tie2-R849W Mutant in Venous Malformations Chronically Activates a Functional STAT1 to Modulate Gene Expression The Journal of Investigative Dermatology. Sep, 2008 | Pubmed ID: 18401423 STAT3 Positively Regulates an Early Step in B-cell Development Blood. Nov, 2006 | Pubmed ID: 16825489 Stat1 and Stat2 but Not Stat3 Arbitrate Contradictory Growth Signals Elicited by Alpha/beta Interferon in T Lymphocytes Molecular and Cellular Biology. Jul, 2005 | Pubmed ID: 15964802 Tissue-specific Positive Feedback Requirements for Production of Type I Interferon Following Virus Infection The Journal of Biological Chemistry. May, 2005 | Pubmed ID: 15767254 STAT3 is a Negative Regulator of Granulopoiesis but is Not Required for G-CSF-dependent Differentiation Immunity. Jul, 2002 | Pubmed ID: 12150892 What Does Stat3 Do? The Journal of Clinical Investigation. May, 2002 | Pubmed ID: 11994402 एक हेमटोपोइएटिक स्टेम और पूर्वज सेल लाइन इन विट्रो में शॉर्ट हेयरपिन आरएनए-मध्यस्थता जीन नॉकडाउन द्वारा डेंड्राइटिक सेल विकास का अध्ययन Yu-Ling Hsiao1, Hans Häcker2, Chien-Kuo Lee1 1Graduate Institute of Immunology, National Taiwan University College of Medicine, 2Department of Pathology, Division of Microbiology and Immunology, University of Utah JoVE 62730 Immunology and Infection एसी-6 फीडर सिस्टम का उपयोग आम लिम्फायड progenitors से Murine Plasmacytoid वृक्ष के समान कोशिकाओं की इन विट्रो पीढ़ी में Shiun Chang1, Li-Mei Pai2,3, Chien-Kuo Lee1 1Graduate Institute of Immunology, National Taiwan University College of Medicine, 2Department of Biochemistry, Chang Gung University College of Medicine, 3Molecular Medicine Research Center, Chang Gung University College of Medicine Immunology and Infection
एक हेमटोपोइएटिक स्टेम और पूर्वज सेल लाइन इन विट्रो में शॉर्ट हेयरपिन आरएनए-मध्यस्थता जीन नॉकडाउन द्वारा डेंड्राइटिक सेल विकास का अध्ययन Yu-Ling Hsiao1, Hans Häcker2, Chien-Kuo Lee1 1Graduate Institute of Immunology, National Taiwan University College of Medicine, 2Department of Pathology, Division of Microbiology and Immunology, University of Utah JoVE 62730 Immunology and Infection
एसी-6 फीडर सिस्टम का उपयोग आम लिम्फायड progenitors से Murine Plasmacytoid वृक्ष के समान कोशिकाओं की इन विट्रो पीढ़ी में Shiun Chang1, Li-Mei Pai2,3, Chien-Kuo Lee1 1Graduate Institute of Immunology, National Taiwan University College of Medicine, 2Department of Biochemistry, Chang Gung University College of Medicine, 3Molecular Medicine Research Center, Chang Gung University College of Medicine Immunology and Infection
