Choon Nam Ong

NUS Environmental Research Institute & School of Public Health, National University of Singapore

Affiliated withNational University of Singapore

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 9	2019

Other Publications

Article	Year
Coenzyme Q10 and differences in coronary heart disease risk in Asian Indians and Chinese. Free radical biology & medicine\| PubMed ID: 11796201	2002
Calpain activation after mitochondrial permeability transition in microcystin-induced cell death in rat hepatocytes. Biochemical and biophysical research communications\| PubMed ID: 11846407	2002
Detection of apoptotic alterations in sperm in subfertile patients and their correlations with sperm quality. Human reproduction (Oxford, England)\| PubMed ID: 11980750	2002
Intracellular glutathione is a cofactor in methylseleninic acid-induced apoptotic cell death of human hepatoma HEPG(2) cells. Free radical biology & medicine\| PubMed ID: 12160937	2002
Biomarkers for male reproductive health hazards: are they available? Toxicology letters\| PubMed ID: 12191857	2002
Inhibition of peroxynitrite-mediated cellular toxicity, tyrosine nitration, and alpha1-antiproteinase inactivation by 3-mercapto-2-methylpentan-1-ol, a novel compound isolated from Allium ce... Biochemical and biophysical research communications\| PubMed ID: 12604361	2003
Oxidative DNA damage in peripheral leukocytes and its association with expression and polymorphisms of hOGG1: a study of adolescents in a high risk region for hepatocellular carcinoma in Chi... World journal of gastroenterology\| PubMed ID: 14562375	2003
Simultaneous determination of tocotrienols, tocopherols, retinol, and major carotenoids in human plasma. Clinical chemistry\| PubMed ID: 14633878	2003
A high-throughput and sensitive methodology for the quantification of urinary 8-hydroxy-2'-deoxyguanosine: measurement with gas chromatography-mass spectrometry after single solid-phase extr... The Biochemical journal\| PubMed ID: 14992687	2004
Chemopreventive activity of parthenolide against UVB-induced skin cancer and its mechanisms. Carcinogenesis\| PubMed ID: 15033901	2004
Increased iron staining in the cerebral cortex of cholesterol fed rabbits. Mechanisms of ageing and development\| PubMed ID: 15063107	2004
Critical roles of intracellular thiols and calcium in parthenolide-induced apoptosis in human colorectal cancer cells. Cancer letters\| PubMed ID: 15142672	2004
Inhibitory effect of emodin on tumor invasion through suppression of activator protein-1 and nuclear factor-kappaB. Biochemical pharmacology\| PubMed ID: 15194008	2004
Involvement of proapoptotic Bcl-2 family members in parthenolide-induced mitochondrial dysfunction and apoptosis. Cancer letters\| PubMed ID: 15219941	2004
Suppressed NF-kappaB and sustained JNK activation contribute to the sensitization effect of parthenolide to TNF-alpha-induced apoptosis in human cancer cells. Carcinogenesis\| PubMed ID: 15256485	2004
Luteolin sensitizes tumor necrosis factor-alpha-induced apoptosis in human tumor cells. Oncogene\| PubMed ID: 15334063	2004
Beta-phenylethyl isothiocyanate mediated apoptosis; contribution of Bax and the mitochondrial death pathway. The international journal of biochemistry & cell biology\| PubMed ID: 15381154	2005
Monomeric C18 chromatographic method for the liquid chromatographic determination of lipophilic antioxidants in plants. Journal of chromatography. A\| PubMed ID: 15481265	2004
Omega-3 fatty acids and selenium as coronary heart disease risk modifying factors in Asian Indian and Chinese males. Nutrition (Burbank, Los Angeles County, Calif.)\| PubMed ID: 15561485	2004
beta-Phenylethyl isothiocyanate mediated apoptosis: a proteomic investigation of early apoptotic protein changes. Proteomics\| PubMed ID: 15668997	2005
Occupational health response to SARS. Emerging infectious diseases\| PubMed ID: 15714660	2005
A sensitive liquid chromatographic method for the spectrophotometric determination of urinary trans,trans-muconic acid. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences\| PubMed ID: 15734170	2005
Beta-phenylethyl and 8-methylsulphinyloctyl isothiocyanates, constituents of watercress, suppress LPS induced production of nitric oxide and prostaglandin E2 in RAW 264.7 macrophages. Nitric oxide : biology and chemistry\| PubMed ID: 15917216	2005
Broccoli and watercress suppress matrix metalloproteinase-9 activity and invasiveness of human MDA-MB-231 breast cancer cells. Toxicology and applied pharmacology\| PubMed ID: 15953625	2005
Anti-cancer potential of sesquiterpene lactones: bioactivity and molecular mechanisms. Current medicinal chemistry. Anti-cancer agents\| PubMed ID: 15992352	2005
Parthenolide sensitizes ultraviolet (UV)-B-induced apoptosis via protein kinase C-dependent pathways. Carcinogenesis\| PubMed ID: 16051639	2005
Protein kinase C inhibition and x-linked inhibitor of apoptosis protein degradation contribute to the sensitization effect of luteolin on tumor necrosis factor-related apoptosis-inducing lig... Cancer research\| PubMed ID: 16140950	2005
Down-regulation of c-FLIP contributes to the sensitization effect of 3,3'-diindolylmethane on TRAIL-induced apoptosis in cancer cells. Molecular cancer therapeutics\| PubMed ID: 16373712	2005
Protective effects of Asian green vegetables against oxidant induced cytotoxicity. World journal of gastroenterology\| PubMed ID: 16437686	2005
Proteomic analysis of colorectal cancer reveals alterations in metabolic pathways: mechanism of tumorigenesis. Molecular & cellular proteomics : MCP\| PubMed ID: 16554294	2006
Critical role of pro-apoptotic Bcl-2 family members in andrographolide-induced apoptosis in human cancer cells. Biochemical pharmacology\| PubMed ID: 16740251	2006
Emodin inhibits tumor cell adhesion through disruption of the membrane lipid Raft-associated integrin signaling pathway. Cancer research\| PubMed ID: 16740720	2006
Zinc supplementation decreases the development of atherosclerosis in rabbits. Free radical biology & medicine\| PubMed ID: 16814102	2006
Anti-cancer properties of anthraquinones from rhubarb. Medicinal research reviews\| PubMed ID: 17022020	2007
Identification and characterization of major flavonoids and caffeoylquinic acids in three Compositae plants by LC/DAD-APCI/MS. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences\| PubMed ID: 17084113	2007
Methyl-3-indolylacetate inhibits cancer cell invasion by targeting the MEK1/2-ERK1/2 signaling pathway. Molecular cancer therapeutics\| PubMed ID: 17172432	2006
Workgroup report: public health strategies for reducing aflatoxin exposure in developing countries. Environmental health perspectives\| PubMed ID: 17185282	2006
Qualitative and quantitative analysis of toosendanin in Melia toosendan Sieb. Et Zucc (Meliaceae) with liquid chromatography/tandem mass spectrometry. Rapid communications in mass spectrometry : RCM\| PubMed ID: 17262897	2007
Luteolin sensitizes the anticancer effect of cisplatin via c-Jun NH2-terminal kinase-mediated p53 phosphorylation and stabilization. Molecular cancer therapeutics\| PubMed ID: 17431112	2007
Association of blood lead and homocysteine levels among lead exposed subjects in Vietnam and Singapore. Occupational and environmental medicine\| PubMed ID: 17449564	2007
Autophagy plays a protective role during zVAD-induced necrotic cell death. Autophagy\| PubMed ID: 18253089	2008
Hepatitis B virus infection contributes to oxidative stress in a population exposed to aflatoxin B1 and high-risk for hepatocellular carcinoma. Cancer letters\| PubMed ID: 18280645	2008
Metabonomics investigation of human urine after ingestion of green tea with gas chromatography/mass spectrometry, liquid chromatography/mass spectrometry and (1)H NMR spectroscopy. Rapid communications in mass spectrometry : RCM\| PubMed ID: 18634125	2008
Andrographolide sensitizes cancer cells to TRAIL-induced apoptosis via p53-mediated death receptor 4 up-regulation. Molecular cancer therapeutics\| PubMed ID: 18645026	2008
Peroxyl radical scavenging capacity, polyphenolics, and lipophilic antioxidant profiles of mulberry fruits cultivated in southern China. Journal of agricultural and food chemistry\| PubMed ID: 18817415	2008
Elevated oxidative stress, iron accumulation around microvessels and increased 4-hydroxynonenal immunostaining in zone 1 of the liver acinus in hypercholesterolemic rabbits. Free radical research\| PubMed ID: 19184760	2009
A multi-analytical approach for metabolomic profiling of zebrafish (Danio rerio) livers. Molecular bioSystems\| PubMed ID: 19225620	2009
Comprehensive high-performance liquid chromatographic method for the measurements of lipophilic antioxidants in human plasma. Journal of chromatography. A\| PubMed ID: 19232623	2009
Limited antioxidant effect after consumption of a single dose of tomato sauce by young males, despite a rise in plasma lycopene. Free radical research\| PubMed ID: 19437211	2009
Activation of the PI3K-Akt-mTOR signaling pathway promotes necrotic cell death via suppression of autophagy. Autophagy\| PubMed ID: 19556857	2009
Determination of senkirkine and senecionine in Tussilago farfara using microwave-assisted extraction and pressurized hot water extraction with liquid chromatography tandem mass spectrometry. Talanta\| PubMed ID: 19559918	2009
Combination of 1H nuclear magnetic resonance spectroscopy and liquid chromatography/mass spectrometry with pattern recognition techniques for evaluation of metabolic profile associated with ... Journal of proteome research\| PubMed ID: 19714874	2009
Use of liquid chromatography/tandem mass spectrometry and online databases for identification of phosphocholines and lysophosphatidylcholines in human red blood cells. Rapid communications in mass spectrometry : RCM\| PubMed ID: 19725045	2009
Multiorigination of chromatographic peaks in derivatized GC/MS metabolomics: a confounder that influences metabolic pathway interpretation. Journal of proteome research\| PubMed ID: 19835423	2009
Inhibition of the JAK-STAT3 pathway by andrographolide enhances chemosensitivity of cancer cells to doxorubicin. Biochemical pharmacology\| PubMed ID: 20026083	2010
Biodistribution of gold nanoparticles and gene expression changes in the liver and spleen after intravenous administration in rats. Biomaterials\| PubMed ID: 20044133	2010
Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinase. The Journal of biological chemistry\| PubMed ID: 20123989	2010
Metabolic profiling in colorectal cancer reveals signature metabolic shifts during tumorigenesis. Molecular & cellular proteomics : MCP\| PubMed ID: 20147338	2010
Plasma carotenoids and risk of acute myocardial infarction in the Singapore Chinese Health Study. Nutrition, metabolism, and cardiovascular diseases : NMCD\| PubMed ID: 20227258	2011
Autophagy and oxidative stress associated with gold nanoparticles. Biomaterials\| PubMed ID: 20466420	2010
Characterization, purification, and stability of gold nanoparticles. Biomaterials\| PubMed ID: 20801502	2010
Anticancer effects of aloe-emodin on HepG2 cells: Cellular and proteomic studies. Proteomics. Clinical applications\| PubMed ID: 21136693	2007
Genomic instability of gold nanoparticle treated human lung fibroblast cells. Biomaterials\| PubMed ID: 21543115	2011
Enhancement of the capabilities of liquid chromatography-mass spectrometry with derivatization: general principles and applications. Mass spectrometry reviews\| PubMed ID: 21557289	2011
The induction of epigenetic regulation of PROS1 gene in lung fibroblasts by gold nanoparticles and implications for potential lung injury. Biomaterials\| PubMed ID: 21764123	2011
Toxicogenomic and phenotypic analyses of bisphenol-A early-life exposure toxicity in zebrafish. PloS one\| PubMed ID: 22194820	2011
Andrographolide sensitizes cisplatin-induced apoptosis via suppression of autophagosome-lysosome fusion in human cancer cells. Autophagy\| PubMed ID: 22302005	2012
Plasma vitamin E and coenzyme Q10 are not associated with a lower risk of acute myocardial infarction in Singapore Chinese adults. The Journal of nutrition\| PubMed ID: 22513986	2012
Metabolomics reveals altered metabolic pathways in experimental asthma. American journal of respiratory cell and molecular biology\| PubMed ID: 23144334	2013
Metabolomics studies show dose-dependent toxicity induced by SiO(2) nanoparticles in MRC-5 human fetal lung fibroblasts. Advanced healthcare materials\| PubMed ID: 23184831	2012
Metabolomics of developing zebrafish embryos using gas chromatography- and liquid chromatography-mass spectrometry. Molecular bioSystems\| PubMed ID: 23475132	2013
Occurrence of regulated and emerging iodinated DBPs in the Shanghai drinking water. PloS one\| PubMed ID: 23555742	2013
Metabolic signature shift in type 2 diabetes mellitus revealed by mass spectrometry-based metabolomics. The Journal of clinical endocrinology and metabolism\| PubMed ID: 23633210	2013
The effect of primary particle size on biodistribution of inhaled gold nano-agglomerates. Biomaterials\| PubMed ID: 23639527	2013
Exploratory investigation of plasma metabolomics in human lung adenocarcinoma. Molecular bioSystems\| PubMed ID: 23857124	2013
Serum metabolome and lipidome changes in adult patients with primary dengue infection. PLoS neglected tropical diseases\| PubMed ID: 23967362	2013
Exploratory investigation reveals parallel alteration of plasma fatty acids and eicosanoids in coronary artery disease patients. Prostaglandins & other lipid mediators\| PubMed ID: 24007966	2013
Significant biochemical, biophysical and metabolic diversity in circulating human cord blood reticulocytes. PloS one\| PubMed ID: 24116088	2013
Toxicological profile of small airway epithelial cells exposed to gold nanoparticles. Experimental biology and medicine (Maywood, N.J.)\| PubMed ID: 24157586	2013
Does high-dose coenzyme Q10 improve oxidative damage and clinical outcomes in Parkinson's disease? Antioxidants & redox signaling\| PubMed ID: 24410614	2014
Impact of elevated Ca(2+)/Mg(2+) concentrations of reverse osmosis membrane desalinated seawater on the stability of water pipe materials. Journal of water and health\| PubMed ID: 24642429	2014
Toxicity profiling of water contextual zinc oxide, silver, and titanium dioxide nanoparticles in human oral and gastrointestinal cell systems. Environmental toxicology\| PubMed ID: 24930694	2015
Metabolic profiling of plasma from benign and malignant pulmonary nodules patients using mass spectrometry-based metabolomics. Metabolites\| PubMed ID: 24958138	2013
Combination of in situ preconcentration and on-site analysis for phosphate monitoring in fresh waters. Analytical chemistry\| PubMed ID: 25011428	2014
HILIC-MS for metabolomics: An attractive and complementary approach to RPLC-MS. Mass spectrometry reviews\| PubMed ID: 25284160	2016
Engineering noble metal nanomaterials for environmental applications. Nanoscale\| PubMed ID: 25866322	2015
Pro-inflammatory responses of RAW264.7 macrophages when treated with ultralow concentrations of silver, titanium dioxide, and zinc oxide nanoparticles. Journal of hazardous materials\| PubMed ID: 25956645	2015
Vitamin E Isoform γ-Tocotrienol Downregulates House Dust Mite-Induced Asthma. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 26041537	2015
Degradation of the Common Aqueous Antibiotic Tetracycline using a Carbon Nanotube Electrochemical Filter. Environmental science & technology\| PubMed ID: 26056728	2015
Removal of Microcystis aeruginosa using nano-Fe3O4 particles as a coagulant aid. Environmental science and pollution research international\| PubMed ID: 26194241	2015
MetTailor: dynamic block summary and intensity normalization for robust analysis of mass spectrometry data in metabolomics. Bioinformatics (Oxford, England)\| PubMed ID: 26220962	2015
Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chemical research in toxicology\| PubMed ID: 26340163	2015
Oxidative stress by inorganic nanoparticles. Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology\| PubMed ID: 26359790	2016
Associations between Urinary Excretion of Cadmium and Renal Biomarkers in Nonsmoking Females: A Cross-Sectional Study in Rural Areas of South China. International journal of environmental research and public health\| PubMed ID: 26404328	2015
MicroRNAs as biomarkers of hepatotoxicity in a randomized placebo-controlled study of simvastatin and ubiquinol supplementation. Experimental biology and medicine (Maywood, N.J.)\| PubMed ID: 26429200	2016
Associations of serum organohalogen levels and prostate cancer risk: Results from a case-control study in Singapore. Chemosphere\| PubMed ID: 26498098	2016
A genome-wide association study of n-3 and n-6 plasma fatty acids in a Singaporean Chinese population. Genes & nutrition\| PubMed ID: 26584805	2015
Plasma α-Linolenic and Long-Chain ω-3 Fatty Acids Are Associated with a Lower Risk of Acute Myocardial Infarction in Singapore Chinese Adults. The Journal of nutrition\| PubMed ID: 26609174	2016
Acetylcarnitine Is a Candidate Diagnostic and Prognostic Biomarker of Hepatocellular Carcinoma. Cancer research\| PubMed ID: 26976432	2016
Serum Metabolomics Reveals Serotonin as a Predictor of Severe Dengue in the Early Phase of Dengue Fever. PLoS neglected tropical diseases\| PubMed ID: 27055163	2016
Gold nanocluster sensitized TiO2 nanotube arrays for visible-light driven photoelectrocatalytic removal of antibiotic tetracycline. Nanoscale\| PubMed ID: 27121049	2016
Metabolomics Investigation Reveals Metabolite Mediators Associated with Acute Lung Injury and Repair in a Murine Model of Influenza Pneumonia. Scientific reports\| PubMed ID: 27188343	2016
Plasma fatty acids, oxylipins, and risk of myocardial infarction: the Singapore Chinese Health Study. Journal of lipid research\| PubMed ID: 27371261	2016
Metabolic signatures and risk of type 2 diabetes in a Chinese population: an untargeted metabolomics study using both LC-MS and GC-MS. Diabetologia\| PubMed ID: 27514531	2016
Dietary predictors and plasma concentrations of perfluorinated alkyl acids in a Singapore population. Chemosphere\| PubMed ID: 28056448	2017
Consumption of Red Meat, but Not Cooking Oils High in Polyunsaturated Fat, Is Associated with Higher Arachidonic Acid Status in Singapore Chinese Adults. Nutrients\| PubMed ID: 28146136	2017
Metabolic responses of the growing Daphnia similis to chronic AgNPs exposure as revealed by GC-Q-TOF/MS and LC-Q-TOF/MS. Water research\| PubMed ID: 28237781	2017
Zinc oxide nanoparticles exhibit cytotoxicity and genotoxicity through oxidative stress responses in human lung fibroblasts and . International journal of nanomedicine\| PubMed ID: 28280330	2017
Biological effect of aqueous C aggregates on Scenedesmus obliquus revealed by transcriptomics and non-targeted metabolomics. Journal of hazardous materials\| PubMed ID: 28340994	2017
Biomedical Applications of Nanomaterials as Therapeutics. Current medicinal chemistry\| PubMed ID: 28393698	2018
Serum Metabolomics Investigation of Humanized Mouse Model of Dengue Virus Infection. Journal of virology\| PubMed ID: 28468882	2017
Meat and Seafood Consumption in Relation to Plasma Metabolic Profiles in a Chinese Population: A Combined Untargeted and Targeted Metabolomics Study. Nutrients\| PubMed ID: 28665358	2017
Relative Validity and Reproducibility of a Food Frequency Questionnaire for Assessing Dietary Intakes in a Multi-Ethnic Asian Population Using 24-h Dietary Recalls and Biomarkers. Nutrients\| PubMed ID: 28946670	2017
Profiling of Plasma Metabolites Suggests Altered Mitochondrial Fuel Usage and Remodeling of Sphingolipid Metabolism in Individuals With Type 2 Diabetes and Kidney Disease. Kidney international reports\| PubMed ID: 29142974	2017
Serum Lipids in Association With Type 2 Diabetes Risk and Prevalence in a Chinese Population. The Journal of clinical endocrinology and metabolism\| PubMed ID: 29267865	2018
Serum metabolome changes in adult patients with severe dengue in the critical and recovery phases of dengue infection. PLoS neglected tropical diseases\| PubMed ID: 29364889	2018
Comparison of hepatic and serum lipid signatures in hepatocellular carcinoma patients leads to the discovery of diagnostic and prognostic biomarkers. Oncotarget\| PubMed ID: 29435160	2018
Profiling of Phenolic Compounds and Antioxidant Activity of 12 Cruciferous Vegetables. Molecules (Basel, Switzerland)\| PubMed ID: 29748497	2018
Plasma fatty acids and risk of colon and rectal cancers in the Singapore Chinese Health Study. NPJ precision oncology\| PubMed ID: 29872717	2017
Detection of Lung Cancer: Concomitant Volatile Organic Compounds and Metabolomic Profiling of Six Cancer Cell Lines of Different Histological Origins. ACS omega\| PubMed ID: 30023907	2018
Metabolite changes behind faster growth and less reproduction of Daphnia similis exposed to low-dose silver nanoparticles. Ecotoxicology and environmental safety\| PubMed ID: 30056340	2018
Occurrence and distribution of pesticides in precipitation as revealed by targeted screening through GC-MS/MS. Chemosphere\| PubMed ID: 30075377	2018
The use of as a model organism to study immune-nanotoxicity. Nanotoxicology\| PubMed ID: 30451554	2019
Metabolites change of Scenedesmus obliquus exerted by AgNPs. Journal of environmental sciences (China)\| PubMed ID: 30528022	2019
Characterization of Plant Volatiles Reveals Distinct Metabolic Profiles and Pathways among 12 Brassicaceae Vegetables. Metabolites\| PubMed ID: 30558181	2018
Use of an integrated metabolomics platform for mechanistic investigations of three commonly used algaecides on cyanobacterium, Microcystis aeruginosa. Journal of hazardous materials\| PubMed ID: 30594710	2019
Serum Amino Acids in Association with Prevalent and Incident Type 2 Diabetes in A Chinese Population. Metabolites\| PubMed ID: 30646552	2019
Reproducibility of Dietary Biomarkers in a Multiethnic Asian Population. Molecular nutrition & food research\| PubMed ID: 30817094	2019
Omega-6-derived oxylipin changes in serum of patients with hepatitis B virus-related liver diseases. Metabolomics : Official journal of the Metabolomic Society\| PubMed ID: 30830341	2018
Metabolic signatures of four major histological types of lung cancer cells. Metabolomics : Official journal of the Metabolomic Society\| PubMed ID: 30830374	2018
Impacts of peat-forest smoke on urban PM in the Maritime Continent during 2012-2015: Carbonaceous profiles and indicators. Environmental pollution (Barking, Essex : 1987)\| PubMed ID: 30831346	2019
Employing multi-omics to elucidate the hormetic response against oxidative stress exerted by nC on Daphnia pulex. Environmental pollution (Barking, Essex : 1987)\| PubMed ID: 31071629	2019
Dydrogesterone exposure induces zebrafish ovulation but leads to oocytes over-ripening: An integrated histological and metabolomics study. Environment international\| PubMed ID: 31078873	2019
Targeted metabolomics reveals differential biological effects of nanoplastics and nanoZnO in human lung cells. Nanotoxicology\| PubMed ID: 31272252	2019
Male-biased zebrafish sex differentiation and metabolomics profile changes caused by dydrogesterone. Aquatic toxicology (Amsterdam, Netherlands)\| PubMed ID: 31319296	2019
A Dietary Pattern Derived from Reduced Rank Regression and Fatty Acid Biomarkers Is Associated with Lower Risk of Type 2 Diabetes and Coronary Artery Disease in Chinese Adults. The Journal of nutrition\| PubMed ID: 31386157	2019
Simultaneous Quantification of 22 Glucosinolates in 12 Vegetables by Hydrophilic Interaction Chromatography-Tandem Mass Spectrometry. ACS omega\| PubMed ID: 31458210	2018
Association between serum heavy metals and prostate cancer risk - A multiple metal analysis. Environment international\| PubMed ID: 31491608	2019
Association between maternal carotenoids, vitamin A and vitamin E levels and allergic outcomes in the offspring in the first 5 years of life. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology\| PubMed ID: 31532016	2019