Christoph Winkler

Department of Biological Sciences, National University of Singapore

Affiliated withNational University of Singapore

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 10	2017

Other Publications

Article	Year
A duplicated copy of DMRT1 in the sex-determining region of the Y chromosome of the medaka, Oryzias latipes. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12193652	2002
The pro-opiomelanocortin gene of the zebrafish (Danio rerio). Biochemical and biophysical research communications\| PubMed ID: 12684052	2003
The lamina-associated polypeptide 2 (LAP2) isoforms beta, gamma and omega of zebrafish: developmental expression and behavior during the cell cycle. Journal of cell science\| PubMed ID: 12734396	2003
Functional divergence of two zebrafish midkine growth factors following fish-specific gene duplication. Genome research\| PubMed ID: 12743018	2003
Characterization of hey bHLH genes in teleost fish. Development genes and evolution\| PubMed ID: 14593478	2003
A systematic genome-wide screen for mutations affecting organogenesis in Medaka, Oryzias latipes. Mechanisms of development\| PubMed ID: 15210174	2004
Mutations affecting somite formation in the Medaka (Oryzias latipes). Mechanisms of development\| PubMed ID: 15210175	2004
Mutations affecting retina development in Medaka. Mechanisms of development\| PubMed ID: 15210178	2004
Activation of the mouse Oct4 promoter in medaka embryonic stem cells and its use for ablation of spontaneous differentiation. Mechanisms of development\| PubMed ID: 15210197	2004
Developmentally regulated and non-sex-specific expression of autosomal dmrt genes in embryos of the Medaka fish (Oryzias latipes). Mechanisms of development\| PubMed ID: 15210205	2004
her7 and hey1, but not lunatic fringe show dynamic expression during somitogenesis in medaka (Oryzias latipes). Gene expression patterns : GEP\| PubMed ID: 15261833	2004
The lamina-associated polypeptide 2 (LAP2) genes of zebrafish and chicken: no LAP2alpha isoform is synthesised by non-mammalian vertebrates. European journal of cell biology\| PubMed ID: 15506564	2004
Hedgehog and retinoid signalling confines nkx2.2b expression to the lateral floor plate of the zebrafish trunk. Mechanisms of development\| PubMed ID: 15582776	2005
Medial floor plate formation in zebrafish consists of two phases and requires trunk-derived Midkine-a. Genes & development\| PubMed ID: 15833916	2005
Reduced U snRNP assembly causes motor axon degeneration in an animal model for spinal muscular atrophy. Genes & development\| PubMed ID: 16204184	2005
Identification and comparative expression analysis of a second wt1 gene in zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists\| PubMed ID: 16292775	2006
Radioactive 26Al from massive stars in the Galaxy. Nature\| PubMed ID: 16397491	2006
Comparative analysis of her genes during fish somitogenesis suggests a mouse/chick-like mode of oscillation in medaka. Development genes and evolution\| PubMed ID: 16544152	2006
her1 and her13.2 are jointly required for somitic border specification along the entire axis of the fish embryo. Developmental biology\| PubMed ID: 16545363	2006
Dynamic expression of sparc precedes formation of skeletal elements in the Medaka (Oryzias latipes). Gene\| PubMed ID: 16545530	2006
Structural and functional characterization of the zebrafish lamin B receptor. European journal of cell biology\| PubMed ID: 16759737	2006
Discontinuous organization and specification of the lateral floor plate in zebrafish. Developmental biology\| PubMed ID: 17045256	2007
Pituitary-interrenal interaction in zebrafish interrenal organ development. Molecular endocrinology (Baltimore, Md.)\| PubMed ID: 17082325	2007
Inhibition of primordial germ cell proliferation by the medaka male determining gene Dmrt I bY. BMC developmental biology\| PubMed ID: 17760954	2007
Effect of verapamil on tachycardia-induced early cellular electrical remodeling in rabbit atrium. Naunyn-Schmiedeberg's archives of pharmacology\| PubMed ID: 17874072	2007
Midkine-b regulates cell specification at the neural plate border in zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists\| PubMed ID: 18058915	2008
An asymmetric distribution of positrons in the Galactic disk revealed by gamma-rays. Nature\| PubMed ID: 18185581	2008
Tissue-specific expression of dmrt genes in embryos and adults of the platyfish Xiphophorus maculatus. Zebrafish\| PubMed ID: 18377213	2006
Influence of verapamil on tachycardia-induced alterations of PP1 and PP2A in rabbit atrium. Experimental and clinical cardiology\| PubMed ID: 18651001	2007
Retinoic acid and Cyp26b1 are critical regulators of osteogenesis in the axial skeleton. Development (Cambridge, England)\| PubMed ID: 18927155	2008
Osterix-mCherry transgenic medaka for in vivo imaging of bone formation. Developmental dynamics : an official publication of the American Association of Anatomists\| PubMed ID: 19097055	2009
Phylogenetic and evolutionary relationships and developmental expression patterns of the zebrafish twist gene family. Development genes and evolution\| PubMed ID: 19565261	2009
The heterogeneous nuclear ribonucleoprotein-R is necessary for axonal beta-actin mRNA translocation in spinal motor neurons. Human molecular genetics\| PubMed ID: 20167579	2010
Accessibility of host cell lineages to medaka stem cells depends on genetic background and irradiation of recipient embryos. Cellular and molecular life sciences : CMLS\| PubMed ID: 20238480	2010
Tgfbeta3 regulation of chondrogenesis and osteogenesis in zebrafish is mediated through formation and survival of a subpopulation of the cranial neural crest. Mechanisms of development\| PubMed ID: 20406684	2010
Bioreduction of alpha-methylcinnamaldehyde derivatives: chemo-enzymatic asymmetric synthesis of Lilial and Helional. Dalton transactions (Cambridge, England : 2003)\| PubMed ID: 20461254	2010
Genetic analysis of somite formation in laboratory fish models. Advances in experimental medicine and biology\| PubMed ID: 21038770	2008
Systemic splicing factor deficiency causes tissue-specific defects: a zebrafish model for retinitis pigmentosa. Human molecular genetics\| PubMed ID: 21051334	2011
Combined in vivo imaging and omics approaches reveal metabolism of icaritin and its glycosides in zebrafish larvae. Molecular bioSystems\| PubMed ID: 21445457	2011
Asymmetric bioreduction of alkenes using ene-reductases YersER and KYE1 and effects of organic solvents. Organic letters\| PubMed ID: 21510626	2011
Mutant Prpf31 causes pre-mRNA splicing defects and rod photoreceptor cell degeneration in a zebrafish model for Retinitis pigmentosa. Molecular neurodegeneration\| PubMed ID: 21801444	2011
Rankl-induced osteoclastogenesis leads to loss of mineralization in a medaka osteoporosis model. Development (Cambridge, England)\| PubMed ID: 22096076	2012
The Popeye domain containing 2 (popdc2) gene in zebrafish is required for heart and skeletal muscle development. Developmental biology\| PubMed ID: 22290329	2012
Conditional ablation of osteoblasts in medaka. Developmental biology\| PubMed ID: 22326228	2012
Actin filament tracking in electron tomograms of negatively stained lamellipodia using the localized radon transform. Journal of structural biology\| PubMed ID: 22387240	2012
Actin branching in the initiation and maintenance of lamellipodia. Journal of cell science\| PubMed ID: 22431015	2012
Asymmetric bioreduction of activated alkenes to industrially relevant optically active compounds. Journal of biotechnology\| PubMed ID: 22498437	2012
A substrate-driven approach to determine reactivities of α,β-unsaturated carboxylic esters towards asymmetric bioreduction. Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 22736443	2012
The 1D4 antibody labels outer segments of long double cone but not rod photoreceptors in zebrafish. Investigative ophthalmology & visual science\| PubMed ID: 22743318	2012
Dynamic microtubules at the vegetal cortex predict the embryonic axis in zebrafish. Development (Cambridge, England)\| PubMed ID: 22949618	2012
Chemoenzymatic asymmetric synthesis of pregabalin precursors via asymmetric bioreduction of β-cyanoacrylate esters using ene-reductases. The Journal of organic chemistry\| PubMed ID: 23316696	2013
Structure-function analysis of full-length midkine reveals novel residues important for heparin-binding and zebrafish embryogenesis. The Biochemical journal\| PubMed ID: 23418741	2013
Zebrafish hoxd4a acts upstream of meis1.1 to direct vasculogenesis, angiogenesis and hematopoiesis. PloS one\| PubMed ID: 23554940	2013
Anaplastic lymphoma kinase is required for neurogenesis in the developing central nervous system of zebrafish. PloS one\| PubMed ID: 23667670	2013
Two isoforms of Sister-Of-Mammalian Grainyhead have opposing functions in endothelial cells and in vivo. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 23685552	2013
A col10a1:nlGFP transgenic line displays putative osteoblast precursors at the medaka notochordal sheath prior to mineralization. Developmental biology\| PubMed ID: 23769979	2013
Overcoming co-product inhibition in the nicotinamide independent asymmetric bioreduction of activated C=C-bonds using flavin-dependent ene-reductases. Biotechnology and bioengineering\| PubMed ID: 23794404	2013
Arp2/3 complex is essential for actin network treadmilling as well as for targeting of capping protein and cofilin. Molecular biology of the cell\| PubMed ID: 23885122	2013
SMN deficiency alters Nrxn2 expression and splicing in zebrafish and mouse models of spinal muscular atrophy. Human molecular genetics\| PubMed ID: 24218366	2014
NAD(P)H-independent asymmetric C=C bond reduction catalyzed by ene reductases by using artificial co-substrates as the hydrogen donor. Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 24382795	2014
Osterix/Sp7 regulates biomineralization of otoliths and bone in medaka (Oryzias latipes). Matrix biology : journal of the International Society for Matrix Biology\| PubMed ID: 24407212	2014
Electron tomography and simulation of baculovirus actin comet tails support a tethered filament model of pathogen propulsion. PLoS biology\| PubMed ID: 24453943	2014
Bioreduction and disproportionation of cyclohex-2-enone catalyzed by ene-reductase OYE-1 in 'micro-aqueous' organic solvents. Biotechnology letters\| PubMed ID: 24563324	2014
Identification of promiscuous ene-reductase activity by mining structural databases using active site constellations. Nature communications\| PubMed ID: 24954722	2014
Identification of a PRPF4 loss-of-function variant that abrogates U4/U6.U5 tri-snRNP integration and is associated with retinitis pigmentosa. PloS one\| PubMed ID: 25383878	2014
Dmrt5 controls corticotrope and gonadotrope differentiation in the zebrafish pituitary. Molecular endocrinology (Baltimore, Md.)\| PubMed ID: 25489906	2015
Effect of rubber flooring on dairy cattle stepping behavior and muscle activity. Journal of dairy science\| PubMed ID: 25648801	2015
A Multifunctional Mutagenesis System for Analysis of Gene Function in Zebrafish. G3 (Bethesda, Md.)\| PubMed ID: 25840430	2015
The flatness of Lamellipodia explained by the interaction between actin dynamics and membrane deformation. Journal of theoretical biology\| PubMed ID: 26002996	2015
The Wnt Co-Receptor Lrp5 Is Required for Cranial Neural Crest Cell Migration in Zebrafish. PloS one\| PubMed ID: 26121341	2015
Nitrile as Activating Group in the Asymmetric Bioreduction of β-Cyanoacrylic Acids Catalyzed by Ene-Reductases. Advanced synthesis & catalysis\| PubMed ID: 26190962	2014
An adult osteopetrosis model in medaka reveals the importance of osteoclast function for bone remodeling in teleost fish. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP\| PubMed ID: 26334373	2015
Live imaging of osteoclast inhibition by bisphosphonates in a medaka osteoporosis model. Disease models & mechanisms\| PubMed ID: 26704995	2016
Trametes versicolor carboxylate reductase uncovered. Monatshefte fur chemie\| PubMed ID: 27069283	2016
Transcriptional enhancement of Smn levels in motoneurons is crucial for proper axon morphology in zebrafish. Scientific reports\| PubMed ID: 27273160	2016
A vertebrate specific and essential role for sp7/osterix in osteogenesis revealed by gene knock-out in the teleost medaka. Development (Cambridge, England)\| PubMed ID: 27993982	2016