Chuan-ju Liu Department of Orthopaedic Surgery & Department of Cell Biology NYU School of Medicine Biography Publications Institution JoVE Articles Chuan-ju LiuProfessor of Orthopaedic Surgery and Cell Biology Dr. Chuanju Liu held a dual appointment as an Assistant Professor from Department of Orthopaedic Surgery and Department of Cell Biology at NYU School of Medicine since 2002, and was promoted to Associate Professor with Tenure and Professor with Tenure in 2007 and 2013, respectively. He is the current Editor-in-Chief of Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders and Rheumatology Research and Review, and serves on a number of Editorial Boards. He is also an active participant in peer review of grant applications to various agencies (NIH, DOD, VA, etc.). His current research focuses on inflammatory and degenerative arthritis, cartilage/bone regeneration, and autoimmune diseases. He has published over 140 papers in prestigious journals, including Science, ARD, EMBO J, and PNAS. He is the recipient of numerous awards, including the ASBMR's Harold M. Frost Award, the Arthritis Foundation's Dorothy W. Goldstein Award, the NIH Career Development Award, the Kappa Delta Award from the ORS and AAOS, the Innovative Research Award from the American College of Rheumatology, and the STAR Award from NIH/NIAMS. Publications Progranulin Promotes Diabetic Fracture Healing in Mice with Type 1 Diabetes Annals of the New York Academy of Sciences. Aug, 2019 | Pubmed ID: 31423598 Fexofenadine Inhibits TNF Signaling Through Targeting to Cytosolic Phospholipase A2 and is Therapeutic Against Inflammatory Arthritis Annals of the Rheumatic Diseases. Jul, 2019 | Pubmed ID: 31302596 Progranulin: A Conductor of Receptors Orchestra, a Chaperone of Lysosomal Enzymes and a Therapeutic Target for Multiple Diseases Cytokine & Growth Factor Reviews. 02, 2019 | Pubmed ID: 30733059 Clinical Application of Teriparatide in Fracture Prevention: A Systematic Review JBJS Reviews. Jan, 2019 | Pubmed ID: 30694878 Targeting Tumor Necrosis Factor Receptors in Ankylosing Spondylitis Annals of the New York Academy of Sciences. Apr, 2019 | Pubmed ID: 30008173 Brain-penetrant Heat Shock Protein Amplifier Arimoclomol Enhances GCase Activity in in Vitro Gaucher Disease Models EBioMedicine. 12, 2018 | Pubmed ID: 30522930 Progranulin Associates with Hexosaminidase A and Ameliorates GM2 Ganglioside Accumulation and Lysosomal Storage in Tay-Sachs Disease Journal of Molecular Medicine (Berlin, Germany). Dec, 2018 | Pubmed ID: 30341570 Establishment of a Modified Collagen-Induced Arthritis Mouse Model to Investigate the Anti-inflammatory Activity of Progranulin in Inflammatory Arthritis Methods in Molecular Biology (Clifton, N.J.). 2018 | Pubmed ID: 29956284 Role of ADAMTS-12 in Protecting Against Inflammatory Arthritis in Mice By Interacting With and Inactivating Proinflammatory Connective Tissue Growth Factor Arthritis & Rheumatology (Hoboken, N.J.). 11, 2018 | Pubmed ID: 29750395 Molecular Regulations and Therapeutic Targets of Gaucher Disease Cytokine & Growth Factor Reviews. 06, 2018 | Pubmed ID: 29699937 P204 Is Required for Canonical Lipopolysaccharide-induced TLR4 Signaling in Mice EBioMedicine. Mar, 2018 | Pubmed ID: 29472103 Chitinase-3-like Protein 1: A Progranulin Downstream Molecule and Potential Biomarker for Gaucher Disease EBioMedicine. Feb, 2018 | Pubmed ID: 29396296 Multifunctional Molecule ERp57: From Cancer to Neurodegenerative Diseases Pharmacology & Therapeutics. 01, 2018 | Pubmed ID: 28723413 Progranulin: A Key Player in Autoimmune Diseases Cytokine. 01, 2018 | Pubmed ID: 27527809 Progranulin Derivative Atsttrin Protects Against Early Osteoarthritis in Mouse and Rat Models Arthritis Research & Therapy. Dec, 2017 | Pubmed ID: 29258611 Progranulin Acts As a Shared Chaperone and Regulates Multiple Lysosomal Enzymes Genes & Diseases. Sep, 2017 | Pubmed ID: 28944282 Foxo4- and Stat3-dependent IL-10 Production by Progranulin in Regulatory T Cells Restrains Inflammatory Arthritis FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. 04, 2017 | Pubmed ID: 28011648 Progranulin Recruits HSP70 to β-Glucocerebrosidase and Is Therapeutic Against Gaucher Disease EBioMedicine. Nov, 2016 | Pubmed ID: 27789271 Association Between Progranulin and Gaucher Disease EBioMedicine. Sep, 2016 | Pubmed ID: 27515686 Review: Novel Insights Into Tumor Necrosis Factor Receptor, Death Receptor 3, and Progranulin Pathways in Arthritis and Bone Remodeling Arthritis & Rheumatology (Hoboken, N.J.). 12, 2016 | Pubmed ID: 27428882 Extracellular Matrix Protein 1, a Direct Targeting Molecule of Parathyroid Hormone-related Peptide, Negatively Regulates Chondrogenesis and Endochondral Ossification Via Associating with Progranulin Growth Factor FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. 08, 2016 | Pubmed ID: 27075243 Progranulin Suppresses Titanium Particle Induced Inflammatory Osteolysis by Targeting TNFα Signaling Scientific Reports. Feb, 2016 | Pubmed ID: 26864916 Does Progranulin Account for the Opposite Effects of Etanercept and Infliximab/adalimumab in Osteoarthritis?: Comment on Olson Et Al.: "Therapeutic Opportunities to Prevent Post-Traumatic Arthritis: Lessons From the Natural History of Arthritis After Articular Fracture" Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. Jan, 2016 | Pubmed ID: 26519939 Progranulin Knockout Accelerates Intervertebral Disc Degeneration in Aging Mice Scientific Reports. Mar, 2015 | Pubmed ID: 25777988 Overexpression of ADAMTS-7 Leads to Accelerated Initiation and Progression of Collagen-induced Arthritis in Mice Molecular and Cellular Biochemistry. Jun, 2015 | Pubmed ID: 25742929 Progranulin Protects Against Osteoarthritis Through Interacting with TNF-α and β-Catenin Signalling Annals of the Rheumatic Diseases. Dec, 2015 | Pubmed ID: 25169730 Progranulin Facilitates Conversion and Function of Regulatory T Cells Under Inflammatory Conditions PloS One. 2014 | Pubmed ID: 25393765 PGRN Protects Against Colitis Progression in Mice in an IL-10 and TNFR2 Dependent Manner Scientific Reports. Nov, 2014 | Pubmed ID: 25387791 ADAMTS-18: a Metalloproteinase with Multiple Functions Frontiers in Bioscience (Landmark Edition). Jun, 2014 | Pubmed ID: 24896365 Three TNFR-binding Domains of PGRN Act Independently in Inhibition of TNF-alpha Binding and Activity Frontiers in Bioscience (Landmark Edition). Jun, 2014 | Pubmed ID: 24896343 Progranulin Inhibition of TNFα Immunology and Cell Biology. Feb, 2014 | Pubmed ID: 24518982 Progranulin Directly Binds to the CRD2 and CRD3 of TNFR Extracellular Domains FEBS Letters. Nov, 2013 | Pubmed ID: 24070898 ADAMTS-7 Forms a Positive Feedback Loop with TNF-α in the Pathogenesis of Osteoarthritis Annals of the Rheumatic Diseases. Dec, 2013 | Pubmed ID: 23928557 The Promotion of Bone Healing by Progranulin, a Downstream Molecule of BMP-2, Through Interacting with TNF/TNFR Signaling Biomaterials. Sep, 2013 | Pubmed ID: 23746860 Progranulin Deficiency Exaggerates, Whereas Progranulin-derived Atsttrin Attenuates, Severity of Dermatitis in Mice FEBS Letters. Jun, 2013 | Pubmed ID: 23669357 Prevention of Atrophic Nonunion by the Systemic Administration of Parathyroid Hormone (PTH 1-34) in an Experimental Animal Model Journal of Orthopaedic Trauma. Dec, 2012 | Pubmed ID: 22932751 颗粒蛋白前体的生长因子,一种新型体配体和药物靶。 Pharmacology & Therapeutics. Jan, 2012 | Pubmed ID: 22008260 GEP 构成与 MyoD 的负面反馈循环,并作为新型调解人控制骨骼肌细胞分化。 Cellular and Molecular Life Sciences : CMLS. Dec, 2011 | Pubmed ID: 22179841 颗粒蛋白前体的治疗类风湿性关节炎有希望治疗目标。 FEBS Letters. Dec, 2011 | Pubmed ID: 21550343 颗粒细胞生长因子蛋白前体绑定到肿瘤坏死因子受体,并且是对小鼠炎性关节炎的治疗。 Science (New York, N.Y.). Apr, 2011 | Pubmed ID: 21393509 软骨寡聚基质蛋白抑制血管平滑肌钙化的骨形态发生蛋白-2 与交互。 Circulation Research. Apr, 2011 | Pubmed ID: 21350216 ADAMTSs 在关节炎的作用。 Protein & Cell. Jan, 2010 | Pubmed ID: 21203996 GEP,本地的生长因子及其和釉质形成至关重要。 International Journal of Biological Sciences. 2010 | Pubmed ID: 21152114 基质金属蛋白酶的关联云帆济骨形态发生蛋白-2 体外都是增生性骨折不愈合组织在升高。 Journal of Orthopaedic Trauma. Sep, 2010 | Pubmed ID: 20736794 软骨寡聚基质蛋白与细胞外基质蛋白 1 相互作用介导软骨骨生长。 Matrix Biology : Journal of the International Society for Matrix Biology. May, 2010 | Pubmed ID: 20138147 小菜 Epithelin 前体: 骨人骨形成蛋白 2 诱导生长因子激活 Erk1/2 信号和 JunB 转录因子在软骨形成的。 FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jun, 2010 | Pubmed ID: 20124436 软骨寡聚基质蛋白 Alpha(7)beta(1) 整合素与交互来保持收缩血管平滑肌细胞的表型。 Circulation Research. Feb, 2010 | Pubmed ID: 20019333 骨形态发生蛋白-7 和几个 BMP 拮抗剂的表达水平可能在骨折不愈合中发挥不可或缺的作用: 一项试点研究。 Clinical Orthopaedics and Related Research. Dec, 2009 | Pubmed ID: 19597895 ADAMTS-7,甲状旁腺,直接目标不利调节软骨骨生长的关联和灭活 GEP 生长因子。 Molecular and Cellular Biology. Aug, 2009 | Pubmed ID: 19487464 Microrna 在 Skeletogenesis 中。 Frontiers in Bioscience : a Journal and Virtual Library. 2009 | Pubmed ID: 19273234 和平号空间站-199a 骨人骨形成蛋白 2 响应 MicroRNA,规定了通过直接靶向 Smad1 软骨形成。 The Journal of Biological Chemistry. Apr, 2009 | Pubmed ID: 19251704 ADAMTS 7 介导球囊损伤大鼠动脉血管平滑肌细胞迁移和内膜的形成。 Circulation Research. Mar, 2009 | Pubmed ID: 19168437 ADAMTS 7 和 ADAMTS 12 关节炎发病机制的作用。 Nature Clinical Practice. Rheumatology. Jan, 2009 | Pubmed ID: 19098927 P204,p200 家族蛋白作为一个多功能细胞增殖和分化的监管。 Cytokine & Growth Factor Reviews. Oct-Dec, 2008 | Pubmed ID: 19027346 Inhibition of ADAMTS-7 and ADAMTS-12 Degradation of Cartilage Oligomeric Matrix Protein by Alpha-2-macroglobulin Osteoarthritis and Cartilage. Nov, 2008 | Pubmed ID: 18485748 P204 蛋白克服由 Id 螺旋-环-螺旋蛋白介导 Alpha 1 成骨分化的核心结合因子的抑制作用。 Molecular Biology of the Cell. May, 2008 | Pubmed ID: 18287524 RbAp48 是控制在宫颈癌的人乳头瘤病毒类型 16 转化活动关键调解人。 The Journal of Biological Chemistry. Sep, 2007 | Pubmed ID: 17616526 IFI16 抑制骨与软骨肿瘤细胞的致瘤性与细胞增殖。 Frontiers in Bioscience : a Journal and Virtual Library. 2007 | Pubmed ID: 17569615 由 Sox9、 Sox5 和 Sox6 转录因子和 CBP/300 芯片共软骨寡聚基质蛋白的转录激活。 Frontiers in Bioscience : a Journal and Virtual Library. 2007 | Pubmed ID: 17485346 视网膜母细胞瘤蛋白是必不可少的调解员 Cbfa1 转录因子,从而增加其活动的链接 P204 蛋白的成骨。 The Journal of Biological Chemistry. Jun, 2007 | Pubmed ID: 17439944 蛋白质-蛋白质相互作用和人类有机溶质转运蛋白的膜本地化。 American Journal of Physiology. Gastrointestinal and Liver Physiology. Jun, 2007 | Pubmed ID: 17332473 软骨寡聚基质蛋白前体小菜 Epithelin (GEP) 相关联,并增强 GEP 刺激软骨细胞增殖。 The Journal of Biological Chemistry. Apr, 2007 | Pubmed ID: 17307734 ADAMTS 12 相关联,并降低软骨寡聚基质蛋白。 The Journal of Biological Chemistry. Jun, 2006 | Pubmed ID: 16611630 ADAMTS-7: 金属蛋白酶直接绑定到并降低软骨寡聚基质蛋白。 FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. May, 2006 | Pubmed ID: 16585064 P204 蛋白克服了 P19 小鼠胚胎癌细胞向 Id 蛋白殴打心肌细胞分化的抑制作用。 The Journal of Biological Chemistry. May, 2006 | Pubmed ID: 16556596 P204 是 P19 小鼠胚胎癌细胞向跳动心肌细胞分化的必要条件: 其表达式由心脏 Gata4、 Nkx2.5 和 Tbx5 蛋白激活。 The Journal of Biological Chemistry. May, 2006 | Pubmed ID: 16556595 血清白细胞介素-6 转作为后髋关节和膝关节置换术的假体周围感染的标记。 The Journal of Bone and Joint Surgery. American Volume. Sep, 2005 | Pubmed ID: 16140805 干扰素诱生 P204 蛋白质充当转录共激活因子的 Cbfa1 和增强成骨细胞分化。 The Journal of Biological Chemistry. Jan, 2005 | Pubmed ID: 15557274 白血病淋巴瘤相关因素,阻遏 POZ 域包含转录物,组蛋白去乙酰酶-1 进行交互,并抑制软骨寡聚基质蛋白基因表达与软骨形成。 The Journal of Biological Chemistry. Nov, 2004 | Pubmed ID: 15337766 软骨寡聚基质蛋白基因的消声器元素规定了软骨细胞特异性表达。 Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. Jul, 2004 | Pubmed ID: 15183430 16 KDa 亚基 C 液泡质子泵与回肠 Na + 协会-依赖胆汁酸转运蛋白: 蛋白质-蛋白质相互作用和胞内贩卖。 The Journal of Biological Chemistry. Apr, 2004 | Pubmed ID: 14752118 由成纤维细胞生长因子同源因子 1B 的心脏钠通道 Nav1.5 调制。 The Journal of Biological Chemistry. Jan, 2003 | Pubmed ID: 12401812 MyoD 诱导 P204 蛋白由 Id 蛋白克服了成肌细胞分化的抑制作用。 Molecular and Cellular Biology. May, 2002 | Pubmed ID: 11940648 用于研究拉帕霉素/mTOR相互作用的半定量药物亲和反应目标稳定性 (DARTS) 测定 Chen Zhang*1, Min Cui*1, Yazhou Cui1, Aubryanna Hettinghouse1, Chuan-ju Liu1,2 1Department of Orthopaedic Surgery, New York University Medical Center, 2Department of Cell Biology, New York University School of Medicine JoVE 59656 Biochemistry 建立了外科手术引起的小鼠模型,以调查的progranulin在骨性关节炎的保护作用 Yunpeng Zhao1, Ben Liu1, Chuan-ju Liu2 1Department of Orthopaedic Surgery, NYU Hospital for Joint Diseases, 2Department of Orthopaedic Surgery, New York University Medical Center JoVE 50924 Bioengineering 改良酵母双杂交系统,以确定蛋白与生长因子Progranulin的相互作用 Qing-Yun Tian1, Yun-Peng Zhao1, Chuan-ju Liu1,2 1Department of Orthopaedic Surgery, NYU Hospital for Joint Diseases, 2Department of Cell Biology, New York University School of Medicine JoVE 3562 Biology
用于研究拉帕霉素/mTOR相互作用的半定量药物亲和反应目标稳定性 (DARTS) 测定 Chen Zhang*1, Min Cui*1, Yazhou Cui1, Aubryanna Hettinghouse1, Chuan-ju Liu1,2 1Department of Orthopaedic Surgery, New York University Medical Center, 2Department of Cell Biology, New York University School of Medicine JoVE 59656 Biochemistry
建立了外科手术引起的小鼠模型,以调查的progranulin在骨性关节炎的保护作用 Yunpeng Zhao1, Ben Liu1, Chuan-ju Liu2 1Department of Orthopaedic Surgery, NYU Hospital for Joint Diseases, 2Department of Orthopaedic Surgery, New York University Medical Center JoVE 50924 Bioengineering
改良酵母双杂交系统,以确定蛋白与生长因子Progranulin的相互作用 Qing-Yun Tian1, Yun-Peng Zhao1, Chuan-ju Liu1,2 1Department of Orthopaedic Surgery, NYU Hospital for Joint Diseases, 2Department of Cell Biology, New York University School of Medicine JoVE 3562 Biology