Darren H. Freed

Department of Surgery, University of Alberta

Affiliated withUniversity of Alberta Canadian National Transplant Research Program Mazankowski Alberta Heart Institute

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 4	Year
Publication title Cited by 22	2019
Publication title	2022
Publication title Cited by 1	2022
Publication title Cited by 3	2020

Other Publications

Article	Year
Intermediate-term outcomes of the arterial switch operation for transposition of great arteries in neonates: alive but well? The Journal of thoracic and cardiovascular surgery\| PubMed ID: 17000296	2006
A whole blood-based perfusate provides superior preservation of myocardial function during ex vivo heart perfusion. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation\| PubMed ID: 25447577	2015
Successful repair of donation after circulatory death lungs with large pulmonary embolus using the lung organ care system for ex vivo thrombolysis and subsequent clinical transplantation. Transplantation\| PubMed ID: 25525922	2015
Donor heart preservation: straight up, or on the rocks? Lancet (London, England)\| PubMed ID: 25888084	2015
Basic and Clinical Observations of Mevalonate Depletion on the Mevalonate Signaling Pathway. Current molecular pharmacology\| PubMed ID: 26758946	2017
Clinical and angiographic outcomes associated with surgical revascularization of angiographically borderline 50-69% coronary artery stenoses. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery\| PubMed ID: 26825107	2016
Inhibition of Viability, Proliferation, Cytokines Secretion, Surface Antigen Expression, and Adipogenic and Osteogenic Differentiation of Adipose-Derived Stem Cells by Seven-Day Exposure to ... Stem cells international\| PubMed ID: 26880984	2016
Externally Applied Static Magnetic Field Enhances Cardiac Retention and Functional Benefit of Magnetically Iron-Labeled Adipose-Derived Stem Cells in Infarcted Hearts. Stem cells translational medicine\| PubMed ID: 27400797	2016
Impact of Reperfusion Calcium and pH on the Resuscitation of Hearts Donated After Circulatory Death. The Annals of thoracic surgery\| PubMed ID: 27526656	2017
Functional assessment and transplantation of the donor heart after circulatory death. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation\| PubMed ID: 27916176	2016
A Leukocyte Filter Does Not Provide Further Benefit During Ex Vivo Lung Perfusion. ASAIO journal (American Society for Artificial Internal Organs : 1992)\| PubMed ID: 28234641	2017
Preservation of Myocardial Perfusion and Function by Keeping Hypertrophied Heart Empty and Beating for Valve Surgery: An In Vivo MR Study of Pig Hearts. BioMed research international\| PubMed ID: 28409155	2017
Extended Bridge to Heart and Lung Transplantation Using Pumpless Extracorporeal Lung Assist. The Canadian journal of cardiology\| PubMed ID: 28579162	2017
New Answers to Old Conundrums: What Antibodies, Exosomes and Inflammasomes Bring to the Conversation. Canadian National Transplant Research Program International Summit Report. Transplantation\| PubMed ID: 28731910	2018
Hypoxia enhances the therapeutic potential of superparamagnetic iron oxide-labeled adipose-derived stem cells for myocardial infarction. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban\| PubMed ID: 28786062	2017
Driveline Site Is Not a Predictor of Infection After Ventricular Assist Device Implantation. ASAIO journal (American Society for Artificial Internal Organs : 1992)\| PubMed ID: 29035899	2018
Inhibition of pyruvate dehydrogenase kinase improves pulmonary arterial hypertension in genetically susceptible patients. Science translational medicine\| PubMed ID: 29070699	2017
Negative pressure ventilation decreases inflammation and lung edema during normothermic ex-vivo lung perfusion. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation\| PubMed ID: 29103845	2018
Steroids Limit Myocardial Edema During Ex Vivo Perfusion of Hearts Donated After Circulatory Death. The Annals of thoracic surgery\| PubMed ID: 29382512	2018
Corrigendum to "Preservation of Myocardial Perfusion and Function by Keeping Hypertrophied Heart Empty and Beating for Valve Surgery: An In Vivo MR Study of Pig Hearts". BioMed research international\| PubMed ID: 29457032	2017
Coronary Artery Bypass Surgery Improves Outcomes in Patients With Diabetes and Left Ventricular Dysfunction. Journal of the American College of Cardiology\| PubMed ID: 29471931	2018
Transplantation of Hearts Donated after Circulatory Death. Frontiers in cardiovascular medicine\| PubMed ID: 29487855	2018
Advanced Dilated Cardiomyopathy in a Patient With Hutterite Limb-Girdle Muscular Dystrophy: Use of a Left Ventricular Assist Device. Circulation. Heart failure\| PubMed ID: 29626101	2018
Ex situ liver perfusion: Organ preservation into the future. Transplantation reviews (Orlando, Fla.)\| PubMed ID: 29691119	2018
Normothermic Ex Vivo Machine Perfusion for Liver Grafts Recovered from Donors after Circulatory Death: A Systematic Review and Meta-Analysis. HPB surgery : a world journal of hepatic, pancreatic and biliary surgery\| PubMed ID: 29849531	2018
Ex vivo perfusion induces a time- and perfusate-dependent molecular repair response in explanted porcine lungs. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons\| PubMed ID: 30230229	2018
Preoperative Predictors of Mortality in Short-Term Continuous-Flow Ventricular Assist Devices. ASAIO journal (American Society for Artificial Internal Organs : 1992)\| PubMed ID: 30325847	2019
Disparate Remodeling of the Extracellular Matrix and Proteoglycans in Failing Pediatric Versus Adult Hearts. Journal of the American Heart Association\| PubMed ID: 30371322	2018
Enhanced myocardial protection in cardiac donation after circulatory death using Intralipid postconditioning in a porcine model. Canadian journal of anaesthesia = Journal canadien d'anesthesie\| PubMed ID: 30790198	2019
Myocardial Functional Decline During Prolonged Ex Situ Heart Perfusion. The Annals of thoracic surgery\| PubMed ID: 30872100	2019
Heart Transplantation With Donation After Circulatory Death. Circulation. Heart failure\| PubMed ID: 30998395	2019
Clearance of transaminases during normothermic ex situ liver perfusion. PloS one\| PubMed ID: 31017974	2019
Valve-Sparing Aortic Root Replacement 3 Decades After Repair of Aortico-Left Ventricular Tunnel. The Annals of thoracic surgery\| PubMed ID: 31228410	2020
Continuous Hemodialysis Does Not Improve Graft Function During Ex Vivo Lung Perfusion Over 24 Hours. Transplantation proceedings\| PubMed ID: 31303418	2019
Avoiding initial hypothermia does not improve liver graft quality in a porcine donation after circulatory death (DCD) model of normothermic perfusion. PloS one\| PubMed ID: 31386697	2019
Total parenteral nutrition in ex vivo lung perfusion: Addressing metabolism improves both inflammation and oxygenation. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons\| PubMed ID: 31420938	2019
Mimicking "J-Shaped" and Anisotropic Stress-Strain Behavior of Human and Porcine Aorta by Fabric-Reinforced Elastomer Composites. ACS applied materials & interfaces\| PubMed ID: 31464413	2019
Outcomes following bioprosthetic valve replacement in prior non-cardiac transplant recipients. Clinical transplantation\| PubMed ID: 31556148	2019
Cryopreservation timing is a critical process parameter in a thymic regulatory T-cell therapy manufacturing protocol. Cytotherapy\| PubMed ID: 31810768	2019
Maintaining the permanence principle for death during in situ normothermic regional perfusion for donation after circulatory death organ recovery: A United Kingdom and Canadian proposal. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons\| PubMed ID: 31922653	2020
Addressing organ shortages: progress in donation after circulatory death for liver transplantation Canadian journal of surgery. Journal canadien de chirurgie\| PubMed ID: 32195556	2020
Current techniques and the future of lung preservation. Cryobiology\| PubMed ID: 32361000	2020
The effects of body mass index on outcomes for patients undergoing surgical aortic valve replacement. BMC cardiovascular disorders\| PubMed ID: 32471345	2020
Immunity and Stress Responses Are Induced During Ex Situ Heart Perfusion. Circulation. Heart failure\| PubMed ID: 32498623	2020
A Low-Cost Perfusate Alternative for Ex Vivo Lung Perfusion. Transplantation proceedings\| PubMed ID: 32624230	2020
End-Stage Liver Disease Models and Outcomes in Pediatric Patients Supported With Short-Term Continuous-Flow Ventricular Assist Devices. ASAIO journal (American Society for Artificial Internal Organs : 1992)\| PubMed ID: 32740355
Discharge and Readmission to the Pediatric Cardiac ICU in Pediatric Patients With Durable Ventricular Assist Devices. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies\| PubMed ID: 32769703	2020
Experimental investigation into the effect of compliance of a mock aorta on cardiac performance. PloS one\| PubMed ID: 33044976	2020
Structural Valve Deterioration Is Linked to Increased Immune Infiltrate and Chemokine Expression. Journal of cardiovascular translational research\| PubMed ID: 33089488	2021
The Human Explanted Heart Program: A translational bridge for cardiovascular medicine. Biochimica et biophysica acta. Molecular basis of disease\| PubMed ID: 33141063	2021
Clinical transplantation using negative pressure ventilation ex situ lung perfusion with extended criteria donor lungs. Nature communications\| PubMed ID: 33188221	2020
Impact of sex on cardiac remodeling and long-term outcomes, following mitral valve replacement. Journal of cardiac surgery\| PubMed ID: 33350520	2021
A review of the immune response stimulated by xenogenic tissue heart valves. Scandinavian journal of immunology\| PubMed ID: 33372305	2021
Resveratrol attenuates stimulated T-cell activation and proliferation: potential therapy against cellular rejection in organ transplantation. American journal of clinical and experimental immunology\| PubMed ID: 33489476	2020
Heart donation and transplantation after circulatory determination of death: expert guidance from a Canadian consensus building process. Canadian journal of anaesthesia = Journal canadien d'anesthesie\| PubMed ID: 33543427	2021
The Position of the Heart During Normothermic Ex Situ Heart Perfusion is an Important Factor in Preservation and Recovery of Myocardial Function. ASAIO journal (American Society for Artificial Internal Organs : 1992)\| PubMed ID: 33741785	2021
Lung Transplantation, Pulmonary Endothelial Inflammation, and Ex-Situ Lung Perfusion: A Review. Cells\| PubMed ID: 34200413	2021
Paracorporeal Support in Pediatric Patients: The Role of the Patient-Device Interaction. The Annals of thoracic surgery\| PubMed ID: 34331928	2021
The effects of body mass index on long-term outcomes and cardiac remodeling following mitral valve repair surgery. International journal of obesity (2005)\| PubMed ID: 34373569	2021
Sternal Bone Marrow Harvesting and Culturing Techniques from Patients Undergoing Cardiac Surgery. Micromachines\| PubMed ID: 34442518	2021
Chronic exogenous ketone supplementation blunts the decline of cardiac function in the failing heart. ESC heart failure\| PubMed ID: 34617412	2021
Recellularization of xenograft heart valves reduces the xenoreactive immune response in an in vivo rat model. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery\| PubMed ID: 34633028	2022
Preclinical models of acute liver failure: a comprehensive review. PeerJ\| PubMed ID: 34966588	2021