James C. Morris Eukaryotic Pathogens Innovation Center Clemson University Biography Publications Institution JoVE Articles James C. Morris has not added a biography. If you are James C. Morris and would like to personalize this page please email our Author Liaison for assistance. Publications Synthesis and Evaluation of Benzylamine Inhibitors of Neuropathogenic "Brain-Eating" Amoeba ACS Medicinal Chemistry Letters. Jan, 2024 | Pubmed ID: 38229759 Glucose Metabolism in the Pathogenic Free-living Amoebae: Tempting Targets for Treatment Development Chemical Biology & Drug Design. Jan, 2024 | Pubmed ID: 37864277 Enolase Inhibitors As Early Lead Therapeutics Against Pathogens (Basel, Switzerland). Oct, 2023 | Pubmed ID: 38003754 The Transcriptome of Balamuthia Mandrillaris Trophozoites for Structure-guided Drug Design Scientific Reports. Nov, 2021 | Pubmed ID: 34737367 Naegleria Fowleri: Protein Structures to Facilitate Drug Discovery for the Deadly, Pathogenic Free-living Amoeba PloS One. 2021 | Pubmed ID: 33760815 Dual-Stage Picolinic Acid-Derived Inhibitors of ACS Medicinal Chemistry Letters. Dec, 2020 | Pubmed ID: 33335660 and Human Hexokinases Share Similar Active Sites but Display Distinct Quaternary Architectures IUCrJ. May, 2020 | Pubmed ID: 32431829 Enzymatic and Structural Characterization of the Glucokinase Antimicrobial Agents and Chemotherapy. May, 2019 | Pubmed ID: 30783001 A Microfluidic-Based Microscopy Platform for Continuous Interrogation of Trypanosoma Brucei During Environmental Perturbation Biochemistry. Feb, 2019 | Pubmed ID: 30638014 Glucose Signaling Is Important for Nutrient Adaptation During Differentiation of Pleomorphic African Trypanosomes MSphere. Oct, 2018 | Pubmed ID: 30381351 A FRET Flow Cytometry Method for Monitoring Cytosolic and Glycosomal Glucose in Living Kinetoplastid Parasites PLoS Neglected Tropical Diseases. May, 2018 | Pubmed ID: 29851949 Optimization and Evaluation of Antiparasitic Benzamidobenzoic Acids As Inhibitors of Kinetoplastid Hexokinase 1 ChemMedChem. Dec, 2017 | Pubmed ID: 29105342 A Targeted Delivery Strategy for the Development of Potent Trypanocides Chemical Communications (Cambridge, England). Aug, 2017 | Pubmed ID: 28726862 PH Regulation in Glycosomes of Procyclic Form The Journal of Biological Chemistry. May, 2017 | Pubmed ID: 28348078 Antiparasitic Lethality of Sulfonamidebenzamides in Kinetoplastids Bioorganic & Medicinal Chemistry Letters. Feb, 2017 | Pubmed ID: 28119024 Evaluation of Substituted Ebselen Derivatives As Potential Trypanocidal Agents Bioorganic & Medicinal Chemistry Letters. Feb, 2017 | Pubmed ID: 28043795 Identification of Novel Plasmodium Falciparum Hexokinase Inhibitors with Antiparasitic Activity Antimicrobial Agents and Chemotherapy. Oct, 2016 | Pubmed ID: 27458230 Characterization of an African Trypanosome Mutant Refractory to Lectin-induced Death Biochemistry and Biophysics Reports. Dec, 2015 | Pubmed ID: 26393238 Targeting Protozoan Parasite Metabolism: Glycolytic Enzymes in the Therapeutic Crosshairs Current Medicinal Chemistry. 2014 | Pubmed ID: 24083603 Exploring the Mode of Action of Ebselen in Trypanosoma Brucei Hexokinase Inhibition International Journal for Parasitology. Drugs and Drug Resistance. Dec, 2013 | Pubmed ID: 24533305 Interrogating a Hexokinase-selected Small-molecule Library for Inhibitors of Plasmodium Falciparum Hexokinase Antimicrobial Agents and Chemotherapy. Aug, 2013 | Pubmed ID: 23716053 Environmentally Regulated Glycosome Protein Composition in the African Trypanosome Eukaryotic Cell. Aug, 2013 | Pubmed ID: 23709182 Peptide-targeted Delivery of a PH Sensor for Quantitative Measurements of Intraglycosomal PH in Live Trypanosoma Brucei Biochemistry. May, 2013 | Pubmed ID: 23651061 Extra-glycosomal Localisation of Trypanosoma Brucei Hexokinase 2 International Journal for Parasitology. Apr, 2012 | Pubmed ID: 22619756 Glycolysis in the African Trypanosome: Targeting Enzymes and Their Subcellular Compartments for Therapeutic Development Molecular Biology International. 2011 | Pubmed ID: 22091393 Glycerol 3-phosphate Alters Trypanosoma Brucei Hexokinase Activity in Response to Environmental Change The Journal of Biological Chemistry. Sep, 2011 | Pubmed ID: 21813651 Author Spotlight: Advancements in Glycosomal pH Monitoring in Trypanosoma brucei Using pHluorin2 Biosensor Daniel Call*1, Sabrina S. Pizarro*2,3, Erica Tovey1, Emily Knight2,3, Carrie Baumgardner2,4, Kenneth A. Christensen1, James C. Morris2 1Department Chemistry and Biochemistry, Brigham Young University, 2Eukaryotic Pathogens Innovation Center, Clemson University, 3Department of Genetics and Biochemistry, Clemson University, 4Department of Physics and Astronomy, Clemson University JoVE 66279 Immunology and Infection
Author Spotlight: Advancements in Glycosomal pH Monitoring in Trypanosoma brucei Using pHluorin2 Biosensor Daniel Call*1, Sabrina S. Pizarro*2,3, Erica Tovey1, Emily Knight2,3, Carrie Baumgardner2,4, Kenneth A. Christensen1, James C. Morris2 1Department Chemistry and Biochemistry, Brigham Young University, 2Eukaryotic Pathogens Innovation Center, Clemson University, 3Department of Genetics and Biochemistry, Clemson University, 4Department of Physics and Astronomy, Clemson University JoVE 66279 Immunology and Infection