James K. Chen

Department of Chemical and Systems Biology, Stanford University

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 7	2011

Other Publications

Article	Year
Medulloblastoma growth inhibition by hedgehog pathway blockade. Science (New York, N.Y.)\| PubMed ID: 12202832	2002
Small molecule modulation of Smoothened activity. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12391318	2002
Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened. Genes & development\| PubMed ID: 12414725	2002
Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2. Science (New York, N.Y.)\| PubMed ID: 15618519	2004
Purmorphamine activates the Hedgehog pathway by targeting Smoothened. Nature chemical biology\| PubMed ID: 16408088	2006
Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2. Molecular and cellular biology\| PubMed ID: 16908539	2006
Small-molecule regulation of zebrafish gene expression. Nature chemical biology\| PubMed ID: 17237798	2007
Light-controlled gene silencing in zebrafish embryos. Nature chemical biology\| PubMed ID: 17717538	2007
Gene regulation technologies in zebrafish. Molecular bioSystems\| PubMed ID: 18354783	2008
Fish 'n clicks. Nature chemical biology\| PubMed ID: 18560429	2008
Chemical technologies for probing embryonic development. Chemical Society reviews\| PubMed ID: 18568156	2008
The decoupling of Smoothened from Galphai proteins has little effect on Gli3 protein processing and Hedgehog-regulated chick neural tube patterning. Developmental biology\| PubMed ID: 18590719	2008
A small molecule that binds Hedgehog and blocks its signaling in human cells. Nature chemical biology\| PubMed ID: 19151731	2009
The imidazopyridine derivative JK184 reveals dual roles for microtubules in Hedgehog signaling. Angewandte Chemie (International ed. in English)\| PubMed ID: 19222062	2009
Converse conformational control of smoothened activity by structurally related small molecules. The Journal of biological chemistry\| PubMed ID: 19366682	2009
Germ cell migration in zebrafish is cyclopamine-sensitive but Smoothened-independent. Developmental biology\| PubMed ID: 19389352	2009
Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19666565	2009
Versatile synthesis and rational design of caged morpholinos. Journal of the American Chemical Society\| PubMed ID: 19708646	2009
Controlling destiny through chemistry: small-molecule regulators of cell fate. ACS chemical biology\| PubMed ID: 20000447	2010
Oligonucleotide-based tools for studying zebrafish development. Zebrafish\| PubMed ID: 20392138	2010
Synthetic strategies for studying embryonic development. Chemistry & biology\| PubMed ID: 20609409	2010
Targeted and Conditional Gene Expression Workshop, 8th International Conference on Zebrafish Development and Genetics. Zebrafish\| PubMed ID: 20798783	2008
Chemical 'Jekyll and Hyde's: small-molecule inhibitors of developmental signaling pathways. Chemical Society reviews\| PubMed ID: 21505654	2011
Spatiotemporal control of embryonic gene expression using caged morpholinos. Methods in cell biology\| PubMed ID: 21924162	2011
A crucial requirement for Hedgehog signaling in small cell lung cancer. Nature medicine\| PubMed ID: 21983857	2011
A small-molecule smoothened agonist prevents glucocorticoid-induced neonatal cerebellar injury. Science translational medicine\| PubMed ID: 22013124	2011
Neuropilins are positive regulators of Hedgehog signal transduction. Genes & development\| PubMed ID: 22051878	2011
Hedgehog and retinoic acid signaling cooperate to promote motoneurogenesis in zebrafish. Development (Cambridge, England)\| PubMed ID: 22069185	2011
Roles of Hedgehog pathway components and retinoic acid signalling in specifying zebrafish ventral spinal cord neurons. Development (Cambridge, England)\| PubMed ID: 22069186	2011
Spatiotemporal resolution of the Ntla transcriptome in axial mesoderm development. Nature chemical biology\| PubMed ID: 22286130	2012