Jeung Whan Han

Publications

• Inhibition of Drp1 Ameliorates Synaptic Depression, Aβ Deposition, and Cognitive Impairment in an Alzheimer's Disease Model
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. May, 2017  |   Pubmed ID: 28432138
• A New Manufacturing Process to Remove Thrombogenic Factors (II, VII, IX, X, and XI) from Intravenous Immunoglobulin Gamma Preparations
  Biologicals : Journal of the International Association of Biological Standardization. Jan, 2017  |   Pubmed ID: 27876270
• PKN2 and Cdo Interact to Activate AKT and Promote Myoblast Differentiation
  Cell Death & Disease. Oct, 2016  |   Pubmed ID: 27763641
• Mapping the Technological Knowledge Landscape: The Case of Epigenetics
  Recent Patents on Anti-cancer Drug Discovery. 2016  |   Pubmed ID: 27557814
• Differential Regulation of the Histone Chaperone HIRA During Muscle Cell Differentiation by a Phosphorylation Switch
  Experimental & Molecular Medicine. Aug, 2016  |   Pubmed ID: 27515126
• Epigenetic Role of Nuclear S6K1 in Early Adipogenesis
  BMB Reports. Aug, 2016  |   Pubmed ID: 27439608
• Patent Cliff and Strategic Switch: Exploring Strategic Design Possibilities in the Pharmaceutical Industry
  SpringerPlus. 2016  |   Pubmed ID: 27347468
• S6K1 Phosphorylation of H2B Mediates EZH2 Trimethylation of H3: A Determinant of Early Adipogenesis
  Molecular Cell. May, 2016  |   Pubmed ID: 27151441
• Epigenetic Reader BRD4 Inhibition As a Therapeutic Strategy to Suppress E2F2-cell Cycle Regulation Circuit in Liver Cancer
  Oncotarget. May, 2016  |   Pubmed ID: 27081696
• JQ1, an Inhibitor of the Epigenetic Reader BRD4, Suppresses the Bidirectional MYC-AP4 Axis Via Multiple Mechanisms
  Oncology Reports. Feb, 2016  |   Pubmed ID: 26573731
• Syntaxin 4 Regulates the Surface Localization of a Promyogenic Receptor Cdo Thereby Promoting Myogenic Differentiation
  Skeletal Muscle. 2015  |   Pubmed ID: 26347807
• Identification of Small Molecules That Inhibit the Histone Chaperone Asf1 and Its Chromatin Function
  BMB Reports. Dec, 2015  |   Pubmed ID: 26058396
• Epigenetic Activation of the Foxa2 Gene is Required for Maintaining the Potential of Neural Precursor Cells to Differentiate into Dopaminergic Neurons After Expansion
  Stem Cells and Development. Feb, 2015  |   Pubmed ID: 25233056
• HP1β Suppresses Metastasis of Human Cancer Cells by Decreasing the Expression and Activation of MMP2
  International Journal of Oncology. Dec, 2014  |   Pubmed ID: 25201136
• The Role of Tumor Suppressor Menin in IL-6 Regulation in Mouse Islet Tumor Cells
  Biochemical and Biophysical Research Communications. Aug, 2014  |   Pubmed ID: 25088994
• Reversine Induces Multipotency of Lineage-committed Cells Through Epigenetic Silencing of MiR-133a
  Biochemical and Biophysical Research Communications. Feb, 2014  |   Pubmed ID: 24513286
• DNA Microarray Profiling of Genes Differentially Regulated by Three Heterochromatin Protein 1 (HP1) Homologs in Drosophila
  Biochemical and Biophysical Research Communications. May, 2013  |   Pubmed ID: 23611785
• Dissecting the Roles of the Histone Chaperones Reveals the Evolutionary Conserved Mechanism of Transcription-coupled Deposition of H3.3
  Nucleic Acids Research. May, 2013  |   Pubmed ID: 23563152
• PRMT6 Overexpression Upregulates TSP-1 and Downregulates MMPs: Its Implication in Motility and Invasion
  Biochemical and Biophysical Research Communications. Mar, 2013  |   Pubmed ID: 23380452
• Destabilization of TNF-α MRNA by Rapamycin
  Biomolecules & Therapeutics. Jan, 2012  |   Pubmed ID: 24116273
• Protein L-isoaspartyl Methyltransferase Regulates P53 Activity
  Nature Communications. Jun, 2012  |   Pubmed ID: 22735455
• The Role of Histone Chaperones in Osteoblastic Differentiation of C2C12 Myoblasts
  Biochemical and Biophysical Research Communications. Jul, 2012  |   Pubmed ID: 22705305
• Requirement of Protein L-isoaspartyl O-methyltransferase for Transcriptional Activation of Trefoil Factor 1 (TFF1) Gene by Estrogen Receptor Alpha
  Biochemical and Biophysical Research Communications. Apr, 2012  |   Pubmed ID: 22382029
• Histone Chaperones Cooperate to Mediate Mef2-targeted Transcriptional Regulation During Skeletal Myogenesis
  Biochemical and Biophysical Research Communications. Apr, 2011  |   Pubmed ID: 21414300
• Myogenic Transcriptional Activation of MyoD Mediated by Replication-independent Histone Deposition
  Proceedings of the National Academy of Sciences of the United States of America. Jan, 2011  |   Pubmed ID: 21173268
• HDAC Inhibitors Downregulate MRP2 Expression in Multidrug Resistant Cancer Cells: Implication for Chemosensitization
  International Journal of Oncology. Mar, 2011  |   Pubmed ID: 21170509
• Foxa2 and Nurr1 Synergistically Yield A9 Nigral Dopamine Neurons Exhibiting Improved Differentiation, Function, and Cell Survival
  Stem Cells (Dayton, Ohio). Mar, 2010  |   Pubmed ID: 20049900
• The Tumor Suppressor, Parafibromin, Mediates Histone H3 K9 Methylation for Cyclin D1 Repression
  Nucleic Acids Research. Jan, 2010  |   Pubmed ID: 19906718
• A Novel Gamma-lactam-based Histone Deacetylase Inhibitor Potently Inhibits the Growth of Human Breast and Renal Cancer Cells
  Biological & Pharmaceutical Bulletin. Oct, 2009  |   Pubmed ID: 19801834
• Oral Administration of Curcumin Suppresses Production of Matrix Metalloproteinase (MMP)-1 and MMP-3 to Ameliorate Collagen-induced Arthritis: Inhibition of the PKCdelta/JNK/c-Jun Pathway
  Journal of Pharmacological Sciences. Sep, 2009  |   Pubmed ID: 19763044
• Depletion of Embryonic Stem Cell Signature by Histone Deacetylase Inhibitor in NCCIT Cells: Involvement of Nanog Suppression
  Cancer Research. Jul, 2009  |   Pubmed ID: 19567677
• Rapamycin Down-regulates Inducible Nitric Oxide Synthase by Inducing Proteasomal Degradation
  Biological & Pharmaceutical Bulletin. Jun, 2009  |   Pubmed ID: 19483303
• Reversine Increases the Plasticity of Lineage-committed Cells Toward Neuroectodermal Lineage
  The Journal of Biological Chemistry. Jan, 2009  |   Pubmed ID: 19015271
• Lysophosphatidic Acid Receptor 2 and Gi/Src Pathway Mediate Cell Motility Through Cyclooxygenase 2 Expression in CAOV-3 Ovarian Cancer Cells
  Experimental & Molecular Medicine. Dec, 2008  |   Pubmed ID: 19116446
• Histone Deacetylase Inhibitor KBH-A42 Inhibits Cytokine Production in RAW 264.7 Macrophage Cells and in Vivo Endotoxemia Model
  Experimental & Molecular Medicine. Oct, 2008  |   Pubmed ID: 18985016
• TIMP-2 Disrupts FGF-2-induced Downstream Signaling Pathways
  Microvascular Research. Nov, 2008  |   Pubmed ID: 18721821
• Curcumin, a Constituent of Curry, Suppresses IgE-mediated Allergic Response and Mast Cell Activation at the Level of Syk
  The Journal of Allergy and Clinical Immunology. May, 2008  |   Pubmed ID: 18394691
• Histone Deacetylase Inhibitor Apicidin-mediated Drug Resistance: Involvement of P-glycoprotein
  Biochemical and Biophysical Research Communications. Apr, 2008  |   Pubmed ID: 18275843
• Hypoxia Enhances LPA-induced HIF-1alpha and VEGF Expression: Their Inhibition by Resveratrol
  Cancer Letters. Dec, 2007  |   Pubmed ID: 17919812
• Histone Chaperones Regulate Histone Exchange During Transcription
  The EMBO Journal. Oct, 2007  |   Pubmed ID: 17914459
• Modification of Cap Group in Delta-lactam-based Histone Deacetylase (HDAC) Inhibitors
  Bioorganic & Medicinal Chemistry Letters. Nov, 2007  |   Pubmed ID: 17904843
• Reversine Stimulates Adipocyte Differentiation and Downregulates Akt and P70(s6k) Signaling Pathways in 3T3-L1 Cells
  Biochemical and Biophysical Research Communications. Jun, 2007  |   Pubmed ID: 17490611
• Suppression of the NF-kappaB Signalling Pathway by Ergolide, Sesquiterpene Lactone, in HeLa Cells
  The Journal of Pharmacy and Pharmacology. Apr, 2007  |   Pubmed ID: 17430640
• Meliae Cortex Extract Exhibits Anti-allergic Activity Through the Inhibition of Syk Kinase in Mast Cells
  Toxicology and Applied Pharmacology. May, 2007  |   Pubmed ID: 17395225
• Coordinated Change of a Ratio of Methylated H3-lysine 4 or Acetylated H3 to Acetylated H4 and DNA Methylation is Associated with Tissue-specific Gene Expression in Cloned Pig
  Experimental & Molecular Medicine. Feb, 2007  |   Pubmed ID: 17334232
• Reversal of Multidrug Resistance by 4-chloro-N-(3-((E)-3-(4-hydroxy-3-methoxyphenyl)acryloyl)phenyl)benzamide Through the Reversible Inhibition of P-glycoprotein
  Biochemical and Biophysical Research Communications. Mar, 2007  |   Pubmed ID: 17286965
• PKCepsilon is Essential for Gelsolin Expression by Histone Deacetylase Inhibitor Apicidin in Human Cervix Cancer Cells
  Biochemical and Biophysical Research Communications. Mar, 2007  |   Pubmed ID: 17257588
• Activation of Hypoxia-inducible Factor-1alpha is Necessary for Lysophosphatidic Acid-induced Vascular Endothelial Growth Factor Expression
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Nov, 2006  |   Pubmed ID: 17085645
• Autotaxin Stimulates Urokinase-type Plasminogen Activator Expression Through Phosphoinositide 3-kinase-Akt-nuclear [corrected] Factor Kappa B Signaling Cascade in Human Melanoma Cells
  Melanoma Research. Oct, 2006  |   Pubmed ID: 17013094
• Involvement of HDAC1 and the PI3K/PKC Signaling Pathways in NF-kappaB Activation by the HDAC Inhibitor Apicidin
  Biochemical and Biophysical Research Communications. Sep, 2006  |   Pubmed ID: 16870149
• Phospholipase D2 Acts As an Essential Adaptor Protein in the Activation of Syk in Antigen-stimulated Mast Cells
  Blood. Aug, 2006  |   Pubmed ID: 16861349
• Immunoglobulin Can Be Functionally Regulated by Protein Carboxylmethylation in Fc Region
  Archives of Pharmacal Research. May, 2006  |   Pubmed ID: 16756083
• Rubiae Radix Suppresses the Activation of Mast Cells Through the Inhibition of Syk Kinase for Anti-allergic Activity
  The Journal of Pharmacy and Pharmacology. Apr, 2006  |   Pubmed ID: 16597368
• Histone Deacetylase Inhibitor Apicidin Induces Cyclin E Expression Through Sp1 Sites
  Biochemical and Biophysical Research Communications. Apr, 2006  |   Pubmed ID: 16516150
• Shp-1 Mediates the Antiproliferative Activity of Tissue Inhibitor of Metalloproteinase-2 in Human Microvascular Endothelial Cells
  The Journal of Biological Chemistry. Feb, 2006  |   Pubmed ID: 16326706
• Cooperation of H2O2-mediated ERK Activation with Smad Pathway in TGF-beta1 Induction of P21WAF1/Cip1
  Cellular Signalling. Feb, 2006  |   Pubmed ID: 15979845
• Apoptotic Potential of Sesquiterpene Lactone Ergolide Through the Inhibition of NF-kappaB Signaling Pathway
  The Journal of Pharmacy and Pharmacology. Dec, 2005  |   Pubmed ID: 16354403
• Suppression of Inducible Nitric Oxide Synthase and Cyclooxygenase-2 Expression in RAW 264.7 Macrophages by Sesquiterpene Lactones
  Journal of Toxicology and Environmental Health. Part A. Dec, 2005  |   Pubmed ID: 16326428
• Beta-Carboline Alkaloid Suppresses NF-kappaB Transcriptional Activity Through Inhibition of IKK Signaling Pathway
  Journal of Toxicology and Environmental Health. Part A. Dec, 2005  |   Pubmed ID: 16326420
• P85 Beta-PIX is Required for Cell Motility Through Phosphorylations of Focal Adhesion Kinase and P38 MAP Kinase
  Experimental Cell Research. Jul, 2005  |   Pubmed ID: 15893751
• Effect of a Fermented Ginseng Extract, BST204, on the Expression of Cyclooxygenase-2 in Murine Macrophages
  International Immunopharmacology. May, 2005  |   Pubmed ID: 15778128
• Development of a Liquid Chromatography/electrospray Tandem Mass Spectrometry Assay for the Quantification of Apicidin, a Novel Histone Deacetylase Inhibitor, in Rat Serum: Application to a Pharmacokinetic Study
  Rapid Communications in Mass Spectrometry : RCM. 2005  |   Pubmed ID: 15645510
• Inhibitory Activity of Chrysanthemi Sibirici Herba Extract on RBL-2H3 Mast Cells and Compound 48/80-induced Anaphylaxis
  Journal of Ethnopharmacology. Dec, 2004  |   Pubmed ID: 15507370
• Hydrogen Peroxide Mediates Rac1 Activation of S6K1
  Experimental Cell Research. Nov, 2004  |   Pubmed ID: 15475011
• Activation of RBL-2H3 Mast Cells is Dependent on Tyrosine Phosphorylation of Phospholipase D2 by Fyn and Fgr
  Molecular and Cellular Biology. Aug, 2004  |   Pubmed ID: 15282299
• In-vitro and In-vivo Anti-allergic Actions of Arecae Semen
  The Journal of Pharmacy and Pharmacology. Jul, 2004  |   Pubmed ID: 15233873
• Activation of P21-activated Kinase 1 is Required for Lysophosphatidic Acid-induced Focal Adhesion Kinase Phosphorylation and Cell Motility in Human Melanoma A2058 Cells
  European Journal of Biochemistry. Apr, 2004  |   Pubmed ID: 15066181
• Apicidin is a Histone Deacetylase Inhibitor with Anti-invasive and Anti-angiogenic Potentials
  Biochemical and Biophysical Research Communications. Mar, 2004  |   Pubmed ID: 14985106
• Hydrogen Peroxide Mediates Arsenite Activation of P70(s6k) and Extracellular Signal-regulated Kinase
  Experimental Cell Research. Oct, 2003  |   Pubmed ID: 14516795
• Expression of P21(WAF1/Cip1) Through Sp1 Sites by Histone Deacetylase Inhibitor Apicidin Requires PI 3-kinase-PKC Epsilon Signaling Pathway
  Oncogene. Sep, 2003  |   Pubmed ID: 12955081
• Purification and Characterization of Nitric Oxide Synthase from Staphylococcus Aureus
  FEMS Microbiology Letters. May, 2003  |   Pubmed ID: 12770704
• Expression of Autotaxin (NPP-2) is Closely Linked to Invasiveness of Breast Cancer Cells
  Clinical & Experimental Metastasis. 2002  |   Pubmed ID: 12498389
• Cdc42 and Rac1 Are Necessary for Autotaxin-induced Tumor Cell Motility in A2058 Melanoma Cells
  FEBS Letters. Dec, 2002  |   Pubmed ID: 12482591
• Doxorubicin Inhibits the Production of Nitric Oxide by Colorectal Cancer Cells
  Archives of Pharmacal Research. Oct, 2002  |   Pubmed ID: 12433207
• Constitutive Activation of P70S6k in Cancer Cells
  Archives of Pharmacal Research. Oct, 2002  |   Pubmed ID: 12433206
• 5-Fluorouracil Inhibits Nitric Oxide Production Through the Inactivation of IkappaB Kinase in Stomach Cancer Cells
  Biochemical Pharmacology. Nov, 2002  |   Pubmed ID: 12417257
• Oligosaccharide-linked Acyl Carrier Protein, a Novel Transmethylase Inhibitor, from Porcine Liver Inhibits Cell Growth
  Archives of Pharmacal Research. Aug, 2002  |   Pubmed ID: 12214857
• Autotaxin Promotes Motility Via G Protein-coupled Phosphoinositide 3-kinase Gamma in Human Melanoma Cells
  FEBS Letters. Mar, 2002  |   Pubmed ID: 11943209
• Apicidin, a Histone Deacetylase Inhibitor, Induces Apoptosis and Fas/Fas Ligand Expression in Human Acute Promyelocytic Leukemia Cells
  The Journal of Biological Chemistry. Jan, 2002  |   Pubmed ID: 11698395