Ji Hyeon Ju

Division of Rheumatology, Seoul St. Mary's Hospital, Institute of Medical Science, Republic of Korea

Affiliated withSeoul St. Mary's Hospital, Institute of Medical Science, Republic of Korea The Catholic University of Korea, Republic of Korea The Catholic University of Korea

Research Area

Developmental Biology

Biography

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JoVE Journal Publications

ArticleTotal : 5	Year
Publication title Cited by 13	2016
Publication title Cited by 16	2016
Publication title Cited by 8	2017
Publication title Cited by 17	2017
Publication title Cited by 27	2019

Other Publications

Article	Year
STAT3 and NF-kappaB signal pathway is required for IL-23-mediated IL-17 production in spontaneous arthritis animal model IL-1 receptor antagonist-deficient mice. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16622035	2006
Antigen-specific expansion of TCR Vbeta3+ CD4+ T cells in the early stage of collagen-induced arthritis and its arthritogenic role in DBA/1J mice. Journal of clinical immunology\| PubMed ID: 16783460	2006
Adenoviral delivery of IL-1 receptor antagonist abrogates disease activity during the development of autoimmune arthritis in IL-1 receptor antagonist-deficient mice. Immunology letters\| PubMed ID: 16793145	2006
Successful treatment of life-threatening intestinal ulcer in Behçet's disease with infliximab: rapid healing of Behçet's ulcer with infliximab. Clinical rheumatology\| PubMed ID: 17039261	2007
Pneumatosis cystoides intestinalis in relapsing polychondritis. Clinical rheumatology\| PubMed ID: 17047889	2007
Cyclosporine A inhibits IL-15-induced IL-17 production in CD4+ T cells via down-regulation of PI3K/Akt and NF-kappaB. Immunology letters\| PubMed ID: 17161467	2007
Toll-like receptor 2 ligand mediates the upregulation of angiogenic factor, vascular endothelial growth factor and interleukin-8/CXCL8 in human rheumatoid synovial fibroblasts. Immunology letters\| PubMed ID: 17182109	2007
Clinical images: visualization of the inner synovial surface with three-dimensional ultrasonography. Arthritis and rheumatism\| PubMed ID: 17195224	2007
Up-regulation of stromal cell-derived factor 1 (CXCL12) production in rheumatoid synovial fibroblasts through interactions with T lymphocytes: role of interleukin-17 and CD40L-CD40 interacti... Arthritis and rheumatism\| PubMed ID: 17393416	2007
Human rheumatoid synovial fibroblasts promote osteoclastogenic activity by activating RANKL via TLR-2 and TLR-4 activation. Immunology letters\| PubMed ID: 17467812	2007
Risk of interstitial lung disease associated with leflunomide treatment in Korean patients with rheumatoid arthritis. Arthritis and rheumatism\| PubMed ID: 17530652	2007
Clinical Images: Earth, moon, and stars in a patient with gouty arthritis. Arthritis and rheumatism\| PubMed ID: 17665397	2007
Clinical images: bamboo spine in a patient with ankylosing spondylitis. Arthritis and rheumatism\| PubMed ID: 17763437	2007
Expression of CCR2A, an isoform of MCP-1 receptor, is increased by MCP-1, CD40 ligand and TGF-beta in fibroblast like synoviocytes of patients with RA. Experimental & molecular medicine\| PubMed ID: 17934338	2007
Oral administration of type-II collagen suppresses IL-17-associated RANKL expression of CD4+ T cells in collagen-induced arthritis. Immunology letters\| PubMed ID: 18242716	2008
Application of three-dimensional computed tomography for the rheumatoid wrist. Rheumatology international\| PubMed ID: 18246353	2008
Cryptococcal meningitis presenting with isolated sixth cranial nerve palsy in a patient with systemic lupus erythematosus. Journal of Korean medical science\| PubMed ID: 18303219	2008
Clinical images: "Melting down" of the cervical spine in a patient with diffuse idiopathic skeletal hyperostosis. Arthritis and rheumatism\| PubMed ID: 18311832	2008
Visualization and localization of rheumatoid knee synovitis with FDG-PET/CT images. Clinical rheumatology\| PubMed ID: 18369527	2008
Three-dimensional ultrasonographic application for analyzing synovial hypertrophy of the knee in patients with osteoarthritis. Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine\| PubMed ID: 18424648	2008
IL-17 induces the production of IL-16 in rheumatoid arthritis. Experimental & molecular medicine\| PubMed ID: 18446062	2008
IL-23 induces receptor activator of NF-kappaB ligand expression on CD4+ T cells and promotes osteoclastogenesis in an autoimmune arthritis model. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18606706	2008
Validity of the sonographic longitudinal sagittal image for assessment of the cartilage thickness in the knee osteoarthritis. Clinical rheumatology\| PubMed ID: 18663556	2008
Treatment with N-tosyl-l-phenylalanine chloromethyl ketone after the onset of collagen-induced arthritis reduces joint erosion and NF-kappaB activation. European journal of pharmacology\| PubMed ID: 18706406	2008
Lupus mesenteric vasculitis can cause acute abdominal pain in patients with SLE. Nature reviews. Rheumatology\| PubMed ID: 19412194	2009
NF-kappaB inhibition leads to increased synthesis and secretion of MIF in human CD4+ T cells. Immunology letters\| PubMed ID: 19428548	2009
Synergism of toll-like receptor 2 (TLR2), TLR4, and TLR6 ligation on the production of tumor necrosis factor (TNF)-alpha in a spontaneous arthritis animal model of interleukin (IL)-1 recepto... Immunology letters\| PubMed ID: 19428561	2009
Grape seed proanthocyanidin extract (GSPE) attenuates collagen-induced arthritis. Immunology letters\| PubMed ID: 19446580	2009
CTLA4-Ig modifies dendritic cells from mice with collagen-induced arthritis to increase the CD4+CD25+Foxp3+ regulatory T cell population. Journal of autoimmunity\| PubMed ID: 19665867	2010
Type II collagen oral tolerance; mechanism and role in collagen-induced arthritis and rheumatoid arthritis. Modern rheumatology / the Japan Rheumatism Association\| PubMed ID: 19697097	2009
Radiologic observation: repair of focal bone erosions after humanized antitumor necrosis factor antibody adalimumab therapy in a patient with rheumatoid arthritis. Clinical rheumatology\| PubMed ID: 19809777	2010
IL-10 suppresses Th17 cells and promotes regulatory T cells in the CD4+ T cell population of rheumatoid arthritis patients. Immunology letters\| PubMed ID: 19895848	2010
The silent progression of metastatic malignancy during the treatment with soluble tumor necrosis factor receptor. Clinical rheumatology\| PubMed ID: 19898739	2010
IL-23 induces receptor activator of NF-kappaB ligand expression in fibroblast-like synoviocytes via STAT3 and NF-kappaB signal pathways. Immunology letters\| PubMed ID: 19900478	2010
Incidence of cancer among female patients with systemic lupus erythematosus in Korea. Clinical rheumatology\| PubMed ID: 20041274	2010
Clinical image: massive bony erosions in the shoulder. Arthritis and rheumatism\| PubMed ID: 20112394	2010
Clinical Images: Visualization of overcompensated rebound temperature against ice-water cold challenge. Arthritis and rheumatism\| PubMed ID: 20131267	2010
Clinical Images: Entero-Behçet's disease. Arthritis and rheumatism\| PubMed ID: 20131289	2010
The change of bone mineral density according to treatment agents in patients with ankylosing spondylitis. Joint, bone, spine : revue du rhumatisme\| PubMed ID: 20621536	2011
Macrophage activation syndrome resistant to medical therapy in a patient with systemic lupus erythematosus and its remission with splenectomy. Rheumatology international\| PubMed ID: 21120496	2013
Engagement of toll-like receptor 3 induces vascular endothelial growth factor and interleukin-8 in human rheumatoid synovial fibroblasts. The Korean journal of internal medicine\| PubMed ID: 21179282	2010
Can we calculate patients' compliance and forecast their adherence to medication: cultural adaptation of the Korean version of a compliance questionnaire for patients with rheumatoid arthrit... The Korean journal of internal medicine\| PubMed ID: 21437158	2011
IL-15 promotes osteoclastogenesis via the PLD pathway in rheumatoid arthritis. Immunology letters\| PubMed ID: 21620893	2011
Grape seed proanthocyanidin extract ameliorates monosodium iodoacetate-induced osteoarthritis. Experimental & molecular medicine\| PubMed ID: 21795829	2011
Measurement of interleukin-33 (IL-33) and IL-33 receptors (sST2 and ST2L) in patients with rheumatoid arthritis. Journal of Korean medical science\| PubMed ID: 21935266	2011
Predictors of chronic kidney disease in Korean patients with lupus nephritis. The Journal of rheumatology\| PubMed ID: 21965650	2011
Interleukin-21 promotes osteoclastogenesis in humans with rheumatoid arthritis and in mice with collagen-induced arthritis. Arthritis and rheumatism\| PubMed ID: 21968544	2012
Impact of interleukin-21 in the pathogenesis of primary Sjögren's syndrome: increased serum levels of interleukin-21 and its expression in the labial salivary glands. Arthritis research & therapy\| PubMed ID: 22030011	2011
A case of leukoencephalopathy associated with adalimumab-treated rheumatoid arthritis and a review of literature. Rheumatology international\| PubMed ID: 22065075	2012
Reactive hemophagocytic syndrome in adult Korean patients with systemic lupus erythematosus: a case-control study and literature review. The Journal of rheumatology\| PubMed ID: 22174206	2012
TLR2 ligation induces the production of IL-23/IL-17 via IL-6, STAT3 and NF-kB pathway in patients with primary Sjogren's syndrome. Arthritis research & therapy\| PubMed ID: 22417709	2012
Tacrolimus treatment increases bone formation in patients with rheumatoid arthritis. Rheumatology international\| PubMed ID: 22447331	2013
Modulation of STAT-3 in rheumatoid synovial T cells suppresses Th17 differentiation and increases the proportion of Treg cells. Arthritis and rheumatism\| PubMed ID: 22736176	2012
Interleukin-27 suppresses osteoclastogenesis via induction of interferon-γ. Immunology\| PubMed ID: 22812379	2012
TWEAK promotes the production of Interleukin-17 in rheumatoid arthritis. Cytokine\| PubMed ID: 22819243	2012
Regression of syndesmophyte after bone marrow transplantation for acute myeloid leukemia in a patient with ankylosing spondylitis: a case report. Journal of medical case reports\| PubMed ID: 22909092	2012
Predictors of end-stage renal disease and recurrence of lupus activity after initiation of dialysis in patients with lupus nephritis. Clinical and experimental rheumatology\| PubMed ID: 22935632	2013
Follow-up of primary Sjogren's syndrome patients presenting positive anti-cyclic citrullinated peptides antibody. Rheumatology international\| PubMed ID: 23179261	2013
Grape-seed proanthocyanidin extract as suppressors of bone destruction in inflammatory autoimmune arthritis. PloS one\| PubMed ID: 23251512	2012
United Rapid Urease Test Is Superior than Separate Test in Detecting Helicobacter pylori at the Gastric Antrum and Body Specimens. Clinical endoscopy\| PubMed ID: 23251887	2012
The paradoxical effects of TNF inhibitors on bone mineral density and radiographic progression in patients with ankylosing spondylitis. Rheumatology (Oxford, England)\| PubMed ID: 23275389	2013
p53 controls autoimmune arthritis via STAT-mediated regulation of the Th17 cell/Treg cell balance in mice. Arthritis and rheumatism\| PubMed ID: 23280308	2013
Periarticular osteoporosis is a prominent feature in early rheumatoid arthritis: estimation using shaft to periarticular bone mineral density ratio. Journal of Korean medical science\| PubMed ID: 23399828	2013
Temporal differential effects of proinflammatory cytokines on osteoclastogenesis. International journal of molecular medicine\| PubMed ID: 23403591	2013
IL-17-mediated Bcl-2 expression regulates survival of fibroblast-like synoviocytes in rheumatoid arthritis through STAT3 activation. Arthritis research & therapy\| PubMed ID: 23421940	2013
Shared epitope and radiologic progression are less prominent in elderly onset RA than young onset RA. Rheumatology international\| PubMed ID: 23443331	2013
Metformin downregulates Th17 cells differentiation and attenuates murine autoimmune arthritis. International immunopharmacology\| PubMed ID: 23557965	2013
Diversity of killer cell immunoglobulin-like receptor genes in uveitis associated with autoimmune diseases: ankylosing spondylitis and Behçet disease. Ocular immunology and inflammation\| PubMed ID: 23697859	2013
TWEAK promotes osteoclastogenesis in rheumatoid arthritis. The American journal of pathology\| PubMed ID: 23845567	2013
The effects of antihypertensive drugs on bone mineral density in ovariectomized mice. Journal of Korean medical science\| PubMed ID: 23960439	2013
Increased levels of interleukin 34 in serum and synovial fluid are associated with rheumatoid factor and anticyclic citrullinated peptide antibody titers in patients with rheumatoid arthriti... The Journal of rheumatology\| PubMed ID: 23996288	2013
Role of citrullinated fibrinogen peptides in the activation of CD4 T cells from patients with rheumatoid arthritis. Immune network\| PubMed ID: 24009538	2013
Comparative proteomic analyses of synovial fluids and serums from rheumatoid arthritis patients. Journal of microbiology and biotechnology\| PubMed ID: 24105271	2014
Activin receptor-like kinase5 inhibition suppresses mouse melanoma by ubiquitin degradation of Smad4, thereby derepressing eomesodermin in cytotoxic T lymphocytes. EMBO molecular medicine\| PubMed ID: 24127404	2013
Grape seed proanthocyanidin extract-mediated regulation of STAT3 proteins contributes to Treg differentiation and attenuates inflammation in a murine model of obesity-associated arthritis. PloS one\| PubMed ID: 24223854	2013
Safe re-administration of tumor necrosis factor-alpha (TNFα) inhibitors in patients with rheumatoid arthritis or ankylosing spondylitis who developed active tuberculosis on previous anti-TNF... Journal of Korean medical science\| PubMed ID: 24431903	2014
Ultrasound examination of wrist compartments in swollen wrists of patients with rheumatoid arthritis. Modern rheumatology / the Japan Rheumatism Association\| PubMed ID: 24471995	2015
Generation of disease-specific induced pluripotent stem cells from patients with rheumatoid arthritis and osteoarthritis. Arthritis research & therapy\| PubMed ID: 24490617	2014
Oestrogen up-regulates interleukin-21 production by CD4(+) T lymphocytes in patients with systemic lupus erythematosus. Immunology\| PubMed ID: 24495300	2014
Gene associated with retinoid-interferon-induced mortality 19 attenuates murine autoimmune arthritis by regulation of th17 and treg cells. Arthritis & rheumatology (Hoboken, N.J.)\| PubMed ID: 24574216	2014
Intravenous immunoglobulin attenuates experimental autoimmune arthritis by inducing reciprocal regulation of Th17 and Treg cells in an interleukin-10-dependent manner. Arthritis & rheumatology (Hoboken, N.J.)\| PubMed ID: 24644005	2014
Induced production of anti-etanercept antibody in collagen-induced arthritis. Molecular medicine reports\| PubMed ID: 24718553	2014
Hyaluronate-gold nanoparticle/tocilizumab complex for the treatment of rheumatoid arthritis. ACS nano\| PubMed ID: 24730974	2014
Immunogenicity of anti-tumour necrosis factor therapy in Korean patients with rheumatoid arthritis and ankylosing spondylitis. International immunopharmacology\| PubMed ID: 24752013	2014
STA-21, a promising STAT-3 inhibitor that reciprocally regulates Th17 and Treg cells, inhibits osteoclastogenesis in mice and humans and alleviates autoimmune inflammation in an experimental... Arthritis & rheumatology (Hoboken, N.J.)\| PubMed ID: 24757144	2014
Multiple osteonecrotic lesions mimicking a piano keyboard in the spine of a patient with catastrophic antiphospholipid syndrome. Arthritis & rheumatology (Hoboken, N.J.)\| PubMed ID: 24838647	2014
Prevalence of systemic lupus erythematosus in South Korea: an administrative database study. Journal of epidemiology / Japan Epidemiological Association\| PubMed ID: 24857955	2014
Incidence and predictors of morphometric vertebral fractures in patients with ankylosing spondylitis. Arthritis research & therapy\| PubMed ID: 24935156	2014
A new strategy to deliver synthetic protein drugs: self-reproducible biologics using minicircles. Scientific reports\| PubMed ID: 25091294	2014
The risk of osteoporotic fractures according to the FRAX model in Korean patients with rheumatoid arthritis. Journal of Korean medical science\| PubMed ID: 25120317	2014
Red ginseng extract ameliorates autoimmune arthritis via regulation of STAT3 pathway, Th17/Treg balance, and osteoclastogenesis in mice and human. Mediators of inflammation\| PubMed ID: 25147435	2014
Positron emission tomography of chronic panniculitis mimicking extranodal lymphoma. Arthritis & rheumatology (Hoboken, N.J.)\| PubMed ID: 25155405	2014
Recent technological updates and clinical applications of induced pluripotent stem cells. The Korean journal of internal medicine\| PubMed ID: 25228828	2014
Cytokine-mediated bone destruction in rheumatoid arthritis. Journal of immunology research\| PubMed ID: 25295284	2014
Role of fractalkine in the pathogenesis of primary Sjögren syndrome: increased serum levels of fractalkine, its expression in labial salivary glands, and the association with clinical manife... The Journal of rheumatology\| PubMed ID: 25320221	2014
Self in vivo production of a synthetic biological drug CTLA4Ig using a minicircle vector. Scientific reports\| PubMed ID: 25374010	2014
Risk of tuberculosis in patients treated with anti-tumor necrosis factor therapy: a nationwide study in South Korea, a country with an intermediate tuberculosis burden. International journal of rheumatic diseases\| PubMed ID: 25557144	2015
A pathogenetic role for IL-21 in primary Sjögren syndrome. Nature reviews. Rheumatology\| PubMed ID: 25584898	2015
Eupatilin ameliorates collagen induced arthritis. Journal of Korean medical science\| PubMed ID: 25729243	2015
Pulmonary hypertension in systemic lupus erythematosus: an independent predictor of patient survival. The Korean journal of internal medicine\| PubMed ID: 25750566	2015
Mycobacterium tuberculosis-specific and MHC class I-restricted CD8+ T-cells exhibit a stem cell precursor-like phenotype in patients with active pulmonary tuberculosis. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases\| PubMed ID: 25809750	2015
Low levels of serum uric Acid increase the risk of low bone mineral density in young male patients with ankylosing spondylitis. The Journal of rheumatology\| PubMed ID: 25834199	2015
Visceral fat obesity is highly associated with primary gout in a metabolically obese but normal weighted population: a case control study. Arthritis research & therapy\| PubMed ID: 25889813	2015
Increased serum alkaline phosphatase levels correlate with high disease activity and low bone mineral density in patients with axial spondyloarthritis. Seminars in arthritis and rheumatism\| PubMed ID: 25895696	2015
Allopurinol hypersensitivity syndrome in patients with hematological malignancies: characteristics and clinical outcomes. The Korean journal of internal medicine\| PubMed ID: 26161019	2015
Phosphorylation status determines the opposing functions of Smad2/Smad3 as STAT3 cofactors in TH17 differentiation. Nature communications\| PubMed ID: 26194464	2015
Human adipose-derived mesenchymal stem cells attenuate collagen antibody-induced autoimmune arthritis by inducing expression of FCGIIB receptors. BMC musculoskeletal disorders\| PubMed ID: 26210906	2015
Application of Minicircle Technology of Self-Reproducing Synthetic Protein Drugs in Preventing Skin Allograft Rejection. Annals of transplantation\| PubMed ID: 26223963	2015
Radiographic Structural Damage Is Worse in the Dominant than the Non-Dominant Hand in Individuals with Early Rheumatoid Arthritis. PloS one\| PubMed ID: 26247204	2015
Fat Metaplasia on Sacroiliac Joint Magnetic Resonance Imaging at Baseline Is Associated with Spinal Radiographic Progression in Patients with Axial Spondyloarthritis. PloS one\| PubMed ID: 26271099	2015
Association of Polymorphisms of Cytochrome P450 2D6 With Blood Hydroxychloroquine Levels in Patients With Systemic Lupus Erythematosus. Arthritis & rheumatology (Hoboken, N.J.)\| PubMed ID: 26316040	2016
Monosodium urate crystal-induced triggering receptor expressed on myeloid cells 1 is associated with acute gouty inflammation. Rheumatology (Oxford, England)\| PubMed ID: 26320130	2016
IL-12p40 Homodimer Ameliorates Experimental Autoimmune Arthritis. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 26324771	2015
Downregulation of Tryptophan-related Metabolomic Profile in Rheumatoid Arthritis Synovial Fluid. The Journal of rheumatology\| PubMed ID: 26329338	2015
Atypical Femoral Fracture in Rheumatoid Arthritis Patients Treated With Bisphosphonates: A Nested Case-Control Study. Arthritis & rheumatology (Hoboken, N.J.)\| PubMed ID: 26360133	2016
Radiographic progression is associated with increased cardiovascular risk in patients with axial spondyloarthritis. Modern rheumatology / the Japan Rheumatism Association\| PubMed ID: 26565692	2016
Development of synthetic anti-cyclic citrullinated peptide antibody and its arthritogenic role. Clinical & translational immunology\| PubMed ID: 26682058	2015
Identification of vanishing tophi by three-dimensional dual-energy computed tomography in a patient with chronic tophaceous gout. Clinical case reports\| PubMed ID: 26783447	2016
A Dual Target-directed Agent against Interleukin-6 Receptor and Tumor Necrosis Factor α ameliorates experimental arthritis. Scientific reports\| PubMed ID: 26841833	2016
IL-1 receptor antagonist (IL-1Ra)-Fc ameliorate autoimmune arthritis by regulation of the Th17 cells/Treg balance and arthrogenic cytokine activation. Immunology letters\| PubMed ID: 26903194	2016
Drs. Kang and Ju reply. The Journal of rheumatology\| PubMed ID: 26932993	2016
Correction: Fat Metaplasia on Sacroiliac Joint Magnetic Resonance Imaging at Baseline Is Associated with Spinal Radiographic Progression in Patients with Axial Spondyloarthritis. PloS one\| PubMed ID: 26954447	2016
Factors related to blood hydroxychloroquine concentration in patients with systemic lupus erythematosus. Arthritis care & research\| PubMed ID: 27390146	2016
Anti-TNFα Treatment for HLA-B27-Positive Ankylosing Spondylitis-Related Uveitis. American journal of ophthalmology\| PubMed ID: 27470062	2016
The Generation of Human Induced Pluripotent Stem Cells from Blood Cells: An Efficient Protocol Using Serial Plating of Reprogrammed Cells by Centrifugation. Stem cells international\| PubMed ID: 27579041	2016
Generation of Functional Cardiomyocytes from the Synoviocytes of Patients with Rheumatoid Arthritis via Induced Pluripotent Stem Cells. Scientific reports\| PubMed ID: 27609119	2016
Centrifugal gravity-induced BMP4 induces chondrogenic differentiation of adipose-derived stem cells via SOX9 upregulation. Stem cell research & therapy\| PubMed ID: 27931264	2016
Positive correlation between inflammation on sacroiliac joint MRI and serum C-terminal telopeptide of type-I collagen in ankylosing spondylitis but not in non-radiographic axial spondyloarth... Clinical and experimental rheumatology\| PubMed ID: 27974096	2016
CRISPR-Cas9: a promising tool for gene editing on induced pluripotent stem cells. The Korean journal of internal medicine\| PubMed ID: 28049282	2017
Etanercept-Synthesising Mesenchymal Stem Cells Efficiently Ameliorate Collagen-Induced Arthritis. Scientific reports\| PubMed ID: 28084468	2017
Cord blood cell-derived iPSCs as a new candidate for chondrogenic differentiation and cartilage regeneration. Stem cell research & therapy\| PubMed ID: 28129782	2017
Recapitulation of methotrexate hepatotoxicity with induced pluripotent stem cell-derived hepatocytes from patients with rheumatoid arthritis. Stem cell research & therapy\| PubMed ID: 30594247	2018
Development of immunocompatible pluripotent stem cells via CRISPR-based human leukocyte antigen engineering. Experimental & molecular medicine\| PubMed ID: 30617277	2019
Predictors of Assessment of Spondyloarthritis International Society (ASAS) Health Index in Axial Spondyloarthritis and Comparison of ASAS Health Index between Ankylosing Spondylitis and Nonr... Journal of clinical medicine\| PubMed ID: 30959846	2019