John L. R. Rubenstein

Department of Psychiatry, University of California San Francisco

Affiliated withUniversity of California San Francisco

Research Area

Developmental Biology

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 35	2015

Other Publications

Article	Year
Expression from a Dlx gene enhancer marks adult mouse cortical GABAergic neurons. Cerebral cortex (New York, N.Y. : 1991)\| PubMed ID: 11734534	2002
Ectopic expression of the Dlx genes induces glutamic acid decarboxylase and Dlx expression. Development (Cambridge, England)\| PubMed ID: 11782417	2002
Slit proteins prevent midline crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrain. Neuron\| PubMed ID: 11804571	2002
Patterning of the basal telencephalon and hypothalamus is essential for guidance of cortical projections. Development (Cambridge, England)\| PubMed ID: 11830575	2002
Cortical and thalamic axon pathfinding defects in Tbr1, Gbx2, and Pax6 mutant mice: evidence that cortical and thalamic axons interact and guide each other. The Journal of comparative neurology\| PubMed ID: 11967891	2002
Distinct origins of neocortical projection neurons and interneurons in vivo. Cerebral cortex (New York, N.Y. : 1991)\| PubMed ID: 12050082	2002
Developmental expression of the T-box transcription factor T-bet/Tbx21 during mouse embryogenesis. Mechanisms of development\| PubMed ID: 12128215	2002
Cortical excitatory neurons and glia, but not GABAergic neurons, are produced in the Emx1-expressing lineage. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 12151506	2002
Specification of jaw subdivisions by Dlx genes. Science (New York, N.Y.)\| PubMed ID: 12193642	2002
Distinct actions of Emx1, Emx2, and Pax6 in regulating the specification of areas in the developing neocortex. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 12196586	2002
Developmental functions of the Distal-less/Dlx homeobox genes. Development (Cambridge, England)\| PubMed ID: 12223397	2002
Modulation of the notch signaling by Mash1 and Dlx1/2 regulates sequential specification and differentiation of progenitor cell types in the subcortical telencephalon. Development (Cambridge, England)\| PubMed ID: 12397111	2002
The early topography of thalamocortical projections is shifted in Ebf1 and Dlx1/2 mutant mice. Development (Cambridge, England)\| PubMed ID: 12421703	2002
DLX5 regulates development of peripheral and central components of the olfactory system. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 12533617	2003
Emx1 and Emx2 cooperate to regulate cortical size, lamination, neuronal differentiation, development of cortical efferents, and thalamocortical pathfinding. The Journal of comparative neurology\| PubMed ID: 12561075	2003
Dosage of Fgf8 determines whether cell survival is positively or negatively regulated in the developing forebrain. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12574514	2003
Cell migration in the forebrain. Annual review of neuroscience\| PubMed ID: 12626695	2003
Directional guidance of interneuron migration to the cerebral cortex relies on subcortical Slit1/2-independent repulsion and cortical attraction. Development (Cambridge, England)\| PubMed ID: 12642493	2003
Molecular regionalization of the neocortex is disrupted in Fgf8 hypomorphic mutants. Development (Cambridge, England)\| PubMed ID: 12642494	2003
Regulatory roles of conserved intergenic domains in vertebrate Dlx bigene clusters. Genome research\| PubMed ID: 12670995	2003
Patterning of the lateral ganglionic eminence by the Gsh1 and Gsh2 homeobox genes regulates striatal and olfactory bulb histogenesis and the growth of axons through the basal ganglia. The Journal of comparative neurology\| PubMed ID: 12724834	2003
Dlx transcription factors regulate differentiation of dopaminergic neurons of the ventral thalamus. Molecular and cellular neurosciences\| PubMed ID: 12799141	2003
The LIM-homeobox gene Lhx8 is required for the development of many cholinergic neurons in the mouse forebrain. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12855770	2003
Graded phenotypic response to partial and complete deficiency of a brain-specific transcript variant of the winged helix transcription factor RFX4. Development (Cambridge, England)\| PubMed ID: 12925582	2003
Forebrain gene expression domains and the evolving prosomeric model. Trends in neurosciences\| PubMed ID: 12948657	2003
Beyond laminar fate: toward a molecular classification of cortical projection/pyramidal neurons. Developmental neuroscience\| PubMed ID: 12966212	2003
Expression of Dbx1, Neurogenin 2, Semaphorin 5A, Cadherin 8, and Emx1 distinguish ventral and lateral pallial histogenetic divisions in the developing mouse claustroamygdaloid complex. The Journal of comparative neurology\| PubMed ID: 15174069	2004
Expression of regulatory genes during differentiation of thalamic nuclei in mouse and monkey. The Journal of comparative neurology\| PubMed ID: 15281080	2004
A focused and efficient genetic screening strategy in the mouse: identification of mutations that disrupt cortical development. PLoS biology\| PubMed ID: 15314648	2004
Intermediate targets in formation of topographic projections: inputs from the thalamocortical system. Trends in neurosciences\| PubMed ID: 15331235	2004
Identification and characterization of a novel transcript down-regulated in Dlx1/Dlx2 and up-regulated in Pax6 mutant telencephalon. Developmental dynamics : an official publication of the American Association of Anatomists\| PubMed ID: 15376329	2004
Short- and long-range attraction of cortical GABAergic interneurons by neuregulin-1. Neuron\| PubMed ID: 15473965	2004
Fgf8 regulates the development of intra-neocortical projections. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 15483110	2004
Identification of Tbr-1/CASK complex target genes in neurons. Journal of neurochemistry\| PubMed ID: 15584924	2004
Dlx1 and Dlx2 function is necessary for terminal differentiation and survival of late-born retinal ganglion cells in the developing mouse retina. Development (Cambridge, England)\| PubMed ID: 15604100	2005
The vertebrate ortholog of Aristaless is regulated by Dlx genes in the developing forebrain. The Journal of comparative neurology\| PubMed ID: 15682394	2005
Developmental regulation of gonadotropin-releasing hormone gene expression by the MSX and DLX homeodomain protein families. The Journal of biological chemistry\| PubMed ID: 15743757	2005
Mice lacking Dlx1 show subtype-specific loss of interneurons, reduced inhibition and epilepsy. Nature neuroscience\| PubMed ID: 16007083	2005
Pax6 is required for making specific subpopulations of granule and periglomerular neurons in the olfactory bulb. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 16049175	2005
Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 16107646	2005
The nuclear receptor COUP-TFI represses differentiation of Cajal-Retzius cells. Brain research bulletin\| PubMed ID: 16144621	2005
Analysis of four DLX homeobox genes in autistic probands. BMC genetics\| PubMed ID: 16266434	2005
Patterning and plasticity of the cerebral cortex. Science (New York, N.Y.)\| PubMed ID: 16272112	2005
Reassessing the Dlx code: the genetic regulation of branchial arch skeletal pattern and development. Journal of anatomy\| PubMed ID: 16313391	2005
New neurons follow the flow of cerebrospinal fluid in the adult brain. Science (New York, N.Y.)\| PubMed ID: 16410488	2006
Dose-dependent functions of Fgf8 in regulating telencephalic patterning centers. Development (Cambridge, England)\| PubMed ID: 16613831	2006
Severe hearing loss in Dlxl mutant mice. Hearing research\| PubMed ID: 16632068	2006
Can autism speak to neuroscience? The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 16807319	2006
Cortical inhibition modified by embryonic neural precursors grafted into the postnatal brain. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 16837585	2006
Dlx-dependent and -independent regulation of olfactory bulb interneuron differentiation. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 17376983	2007
Patterning of frontal cortex subdivisions by Fgf17. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17442747	2007
Inactivation of Arx, the murine ortholog of the X-linked lissencephaly with ambiguous genitalia gene, leads to severe disorganization of the ventral telencephalon with impaired neuronal migr... The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 17460091	2007
Distinct cis-regulatory elements from the Dlx1/Dlx2 locus mark different progenitor cell populations in the ganglionic eminences and different subtypes of adult cortical interneurons. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 17494687	2007
Dlx transcription factors promote migration through repression of axon and dendrite growth. Neuron\| PubMed ID: 17582329	2007
A subpopulation of olfactory bulb GABAergic interneurons is derived from Emx1- and Dlx5/6-expressing progenitors. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 17596436	2007
Dlx1 and Dlx2 control neuronal versus oligodendroglial cell fate acquisition in the developing forebrain. Neuron\| PubMed ID: 17678855	2007
Delineation of multiple subpallial progenitor domains by the combinatorial expression of transcriptional codes. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 17804629	2007
Histogenetic compartments of the mouse centromedial and extended amygdala based on gene expression patterns during development. The Journal of comparative neurology\| PubMed ID: 17990271	2008
COUP-TFI coordinates cortical patterning, neurogenesis, and laminar fate and modulates MAPK/ERK, AKT, and beta-catenin signaling. Cerebral cortex (New York, N.Y. : 1991)\| PubMed ID: 18165280	2008
Regional distribution of cortical interneurons and development of inhibitory tone are regulated by Cxcl12/Cxcr4 signaling. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 18234887	2008
Conserved pattern of OTP-positive cells in the paraventricular nucleus and other hypothalamic sites of tetrapods. Brain research bulletin\| PubMed ID: 18331876	2008
Compartment-specific transcription factors orchestrate angiogenesis gradients in the embryonic brain. Nature neuroscience\| PubMed ID: 18344991	2008
Frontal cortex subdivision patterning is coordinately regulated by Fgf8, Fgf17, and Emx2. The Journal of comparative neurology\| PubMed ID: 18459137	2008
Genetic regulation of prefrontal cortex development and function. Novartis Foundation symposium\| PubMed ID: 18494258	2007
Distinct molecular pathways for development of telencephalic interneuron subtypes revealed through analysis of Lhx6 mutants. The Journal of comparative neurology\| PubMed ID: 18613121	2008
FGF15 promotes neurogenesis and opposes FGF8 function during neocortical development. Neural development\| PubMed ID: 18625063	2008
Dlx genes pattern mammalian jaw primordium by regulating both lower jaw-specific and upper jaw-specific genetic programs. Development (Cambridge, England)\| PubMed ID: 18697905	2008
Characterization of a distinct subpopulation of striatal projection neurons expressing the Dlx genes in the basal ganglia through the activity of the I56ii enhancer. Developmental biology\| PubMed ID: 18706405	2008
Functional disturbances in the striatum by region-specific ablation of NMDA receptors. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18728179	2008
Arx is a direct target of Dlx2 and thereby contributes to the tangential migration of GABAergic interneurons. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 18923043	2008
Autism and brain development. Cell\| PubMed ID: 18984148	2008
Generation of Cre-transgenic mice using Dlx1/Dlx2 enhancers and their characterization in GABAergic interneurons. Molecular and cellular neurosciences\| PubMed ID: 19026749	2009
Dlx1&2 and Mash1 transcription factors control striatal patterning and differentiation through parallel and overlapping pathways. The Journal of comparative neurology\| PubMed ID: 19030180	2009
Dlx1&2 and Mash1 transcription factors control MGE and CGE patterning and differentiation through parallel and overlapping pathways. Cerebral cortex (New York, N.Y. : 1991)\| PubMed ID: 19386638	2009
Genes and signaling events that establish regional patterning of the mammalian forebrain. Seminars in cell & developmental biology\| PubMed ID: 19560042	2009
Reduction of seizures by transplantation of cortical GABAergic interneuron precursors into Kv1.1 mutant mice. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19706400	2009
Arcuate nucleus expression of NKX2.1 and DLX and lineages expressing these transcription factors in neuropeptide Y(+), proopiomelanocortin(+), and tyrosine hydroxylase(+) neurons in neonatal... The Journal of comparative neurology\| PubMed ID: 19711380	2009
Reduced conditioned fear response in mice that lack Dlx1 and show subtype-specific loss of interneurons. Journal of neurodevelopmental disorders\| PubMed ID: 19816534	2009
Indirect modulation of Shh signaling by Dlx5 affects the oral-nasal patterning of palate and rescues cleft palate in Msx1-null mice. Development (Cambridge, England)\| PubMed ID: 19934017	2009
Ikaros-1 couples cell cycle arrest of late striatal precursors with neurogenesis of enkephalinergic neurons. The Journal of comparative neurology\| PubMed ID: 19950118	2010
Three hypotheses for developmental defects that may underlie some forms of autism spectrum disorder. Current opinion in neurology\| PubMed ID: 20087182	2010
A mutation in the pericentrin gene causes abnormal interneuron migration to the olfactory bulb in mice. Developmental biology\| PubMed ID: 20096683	2010
The progenitor zone of the ventral medial ganglionic eminence requires Nkx2-1 to generate most of the globus pallidus but few neocortical interneurons. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 20181579	2010
Repression of Fgf signaling by sprouty1-2 regulates cortical patterning in two distinct regions and times. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 20237272	2010
Role for TGF-beta superfamily signaling in telencephalic GABAergic neuron development. Journal of neurodevelopmental disorders\| PubMed ID: 20339443	2010
Dlx5 and Dlx6 regulate the development of parvalbumin-expressing cortical interneurons. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 20392955	2010
Tbr1 regulates regional and laminar identity of postmitotic neurons in developing neocortex. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20615956	2010
New neurons clear the path of astrocytic processes for their rapid migration in the adult brain. Neuron\| PubMed ID: 20670830	2010
An SNP in an ultraconserved regulatory element affects Dlx5/Dlx6 regulation in the forebrain. Development (Cambridge, England)\| PubMed ID: 20702565	2010
Annual Research Review: Development of the cerebral cortex: implications for neurodevelopmental disorders. Journal of child psychology and psychiatry, and allied disciplines\| PubMed ID: 20735793	2011
Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes. Nature\| PubMed ID: 21068835	2010
CXCR4 and CXCR7 have distinct functions in regulating interneuron migration. Neuron\| PubMed ID: 21220099	2011
Identification of direct downstream targets of Dlx5 during early inner ear development. Human molecular genetics\| PubMed ID: 21227998	2011
Tbr1 and Fezf2 regulate alternate corticofugal neuronal identities during neocortical development. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 21228164	2011
Subregional specification of embryonic stem cell-derived ventral telencephalic tissues by timed and combinatory treatment with extrinsic signals. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 21289201	2011
Deletion of Dlx1 results in reduced glutamatergic input to hippocampal interneurons. Journal of neurophysiology\| PubMed ID: 21325686	2011
Dlx6 regulates molecular properties of the striatum and central nucleus of the amygdala. The Journal of comparative neurology\| PubMed ID: 21452241	2011
Deriving excitatory neurons of the neocortex from pluripotent stem cells. Neuron\| PubMed ID: 21609822	2011
Lhx6 and Lhx8 coordinately induce neuronal expression of Shh that controls the generation of interneuron progenitors. Neuron\| PubMed ID: 21658586	2011
Influence of a subtype of inhibitory interneuron on stimulus-specific responses in visual cortex. Cerebral cortex (New York, N.Y. : 1991)\| PubMed ID: 21666125	2012
A subpopulation of dorsal lateral/caudal ganglionic eminence-derived neocortical interneurons expresses the transcription factor Sp8. Cerebral cortex (New York, N.Y. : 1991)\| PubMed ID: 22021915	2012
Erratum to: Role for TGF-β superfamily signaling in telencephalic GABAergic neuron development. Journal of neurodevelopmental disorders\| PubMed ID: 22127839	2010
COUP-TFII controls amygdala patterning by regulating neuropilin expression. Development (Cambridge, England)\| PubMed ID: 22492355	2012
Chronic reduction in inhibition reduces receptive field size in mouse auditory cortex. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22753490	2012
Nuclear receptor COUP-TFII-expressing neocortical interneurons are derived from the medial and lateral/caudal ganglionic eminence and define specific subsets of mature interneurons. The Journal of comparative neurology\| PubMed ID: 22791192	2013
Hilar GABAergic interneuron activity controls spatial learning and memory retrieval. PloS one\| PubMed ID: 22792368	2012
Subcortical visual shell nuclei targeted by ipRGCs develop from a Sox14+-GABAergic progenitor and require Sox14 to regulate daily activity rhythms. Neuron\| PubMed ID: 22920256	2012
Cleft palate defect of Dlx1/2-/- mutant mice is caused by lack of vertical outgrowth in the posterior palate. Developmental dynamics : an official publication of the American Association of Anatomists\| PubMed ID: 22972697	2012
Loss of Gsx1 and Gsx2 function rescues distinct phenotypes in Dlx1/2 mutants. The Journal of comparative neurology\| PubMed ID: 23042297	2013
Dlx1&2-dependent expression of Zfhx1b (Sip1, Zeb2) regulates the fate switch between cortical and striatal interneurons. Neuron\| PubMed ID: 23312518	2013
A high-resolution enhancer atlas of the developing telencephalon. Cell\| PubMed ID: 23375746	2013
New insights into the classification and nomenclature of cortical GABAergic interneurons. Nature reviews. Neuroscience\| PubMed ID: 23385869	2013
A Subpopulation of Individual Neural Progenitors in the Mammalian Dorsal Pallium Generates Both Projection Neurons and Interneurons vitro. Stem cells (Dayton, Ohio)\| PubMed ID: 23417928	2013
CoupTFI interacts with retinoic acid signaling during cortical development. PloS one\| PubMed ID: 23472160	2013
Functional maturation of hPSC-derived forebrain interneurons requires an extended timeline and mimics human neural development. Cell stem cell\| PubMed ID: 23642366	2013
Use of "MGE enhancers" for labeling and selection of embryonic stem cell-derived medial ganglionic eminence (MGE) progenitors and neurons. PloS one\| PubMed ID: 23658702	2013
Dapper antagonist of catenin-1 cooperates with Dishevelled-1 during postsynaptic development in mouse forebrain GABAergic interneurons. PloS one\| PubMed ID: 23826333	2013
Soluble guanylate cyclase generation of cGMP regulates migration of MGE neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 24155296	2013
Ldb1 is essential for development of Nkx2.1 lineage derived GABAergic and cholinergic neurons in the telencephalon. Developmental biology\| PubMed ID: 24157949	2014
Many human accelerated regions are developmental enhancers. Philosophical transactions of the Royal Society of London. Series B, Biological sciences\| PubMed ID: 24218637	2013
Fezf2 expression identifies a multipotent progenitor for neocortical projection neurons, astrocytes, and oligodendrocytes. Neuron\| PubMed ID: 24314728	2013
Bidirectional homeostatic plasticity induced by interneuron cell death and transplantation in vivo. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24344303	2014
Rapid and pervasive changes in genome-wide enhancer usage during mammalian development. Cell\| PubMed ID: 24360275	2013
Olig1 function is required to repress dlx1/2 and interneuron production in Mammalian brain. Neuron\| PubMed ID: 24507192	2014
Multiple conserved regulatory domains promote Fezf2 expression in the developing cerebral cortex. Neural development\| PubMed ID: 24618363	2014
Lhx6 directly regulates Arx and CXCR7 to determine cortical interneuron fate and laminar position. Neuron\| PubMed ID: 24742460	2014
Major progress towards elucidating brain wiring diagrams. The Journal of comparative neurology\| PubMed ID: 24752413	2014
Transcriptional regulation of enhancers active in protodomains of the developing cerebral cortex. Neuron\| PubMed ID: 24814534	2014
A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron\| PubMed ID: 24952961	2014
Inhibitory interneuron progenitor transplantation restores normal learning and memory in ApoE4 knock-in mice without or with Aβ accumulation. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 25031394	2014
NPAS1 represses the generation of specific subtypes of cortical interneurons. Neuron\| PubMed ID: 25467980	2014
Differential regulation of microtubule severing by APC underlies distinct patterns of projection neuron and interneuron migration. Developmental cell\| PubMed ID: 25535916	2014
Genomic perspectives of transcriptional regulation in forebrain development. Neuron\| PubMed ID: 25569346	2015
Gamma rhythms link prefrontal interneuron dysfunction with cognitive inflexibility in dlx5/6(+/-) mice. Neuron\| PubMed ID: 25754826	2015
A new scenario of hypothalamic organization: rationale of new hypotheses introduced in the updated prosomeric model. Frontiers in neuroanatomy\| PubMed ID: 25852489	2015