John W. Mellors

Publications

• New Tools for Quantifying HIV-1 Reservoirs: Plasma RNA Single Copy Assays and Beyond
  Current HIV/AIDS Reports. Mar, 2012  |   Pubmed ID: 22215419
• No Effect of Raltegravir Intensification on Viral Replication Markers in the Blood of HIV-1-Infected Patients Receiving Antiretroviral Therapy
  Journal of Acquired Immune Deficiency Syndromes (1999). Mar, 2012  |   Pubmed ID: 22083073
• Short-course Raltegravir Intensification Does Not Increase 2 Long Terminal Repeat Episomal HIV-1 DNA in Patients on Effective Antiretroviral Therapy
  Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. Feb, 2012  |   Pubmed ID: 22016501
• Substrate Mimicry: HIV-1 Reverse Transcriptase Recognizes 6-modified-3'-azido-2',3'-dideoxyguanosine-5'-triphosphates As Adenosine Analogs
  Nucleic Acids Research. Jan, 2012  |   Pubmed ID: 21914723
• Short-course Combivir After Single-dose Nevirapine Reduces but Does Not Eliminate the Emergence of Nevirapine Resistance in Women
  Antiviral Therapy. Nov, 2011  |   Pubmed ID: 22293443
• Initial Viral Decay to Assess the Relative Antiretroviral Potency of Protease Inhibitor-sparing, Nonnucleoside Reverse Transcriptase Inhibitor-sparing, and Nucleoside Reverse Transcriptase Inhibitor-sparing Regimens for First-line Therapy of HIV Infection
  AIDS (London, England). Nov, 2011  |   Pubmed ID: 21941167
• Single Genome Sequencing of HIV-1 Gag and Protease Resistance Mutations at Virologic Failure During the OK04 Trial of Simplified Versus Standard Maintenance Therapy
  Antiviral Therapy. 2011  |   Pubmed ID: 21817194
• Synthesis, Antiviral Activity, Cytotoxicity and Cellular Pharmacology of L-3'-azido-2',3'-dideoxypurine Nucleosides
  European Journal of Medicinal Chemistry. Sep, 2011  |   Pubmed ID: 21700368
• Majority of CD4+ T Cells from Peripheral Blood of HIV-1-infected Individuals Contain Only One HIV DNA Molecule
  Proceedings of the National Academy of Sciences of the United States of America. Jul, 2011  |   Pubmed ID: 21690402
• The Base Component of 3'-azido-2',3'-dideoxynucleosides Influences Resistance Mutations Selected in HIV-1 Reverse Transcriptase
  Antimicrobial Agents and Chemotherapy. Aug, 2011  |   Pubmed ID: 21646480
• Role of Low-frequency HIV-1 Variants in Failure of Nevirapine-containing Antiviral Therapy in Women Previously Exposed to Single-dose Nevirapine
  Proceedings of the National Academy of Sciences of the United States of America. May, 2011  |   Pubmed ID: 21576473
• Inhibitors of Histone Deacetylases: Correlation Between Isoform Specificity and Reactivation of HIV Type 1 (HIV-1) from Latently Infected Cells
  The Journal of Biological Chemistry. Jun, 2011  |   Pubmed ID: 21531716
• Factors Influencing the Emergence and Spread of HIV Drug Resistance Arising from Rollout of Antiretroviral Pre-exposure Prophylaxis (PrEP)
  PloS One. 2011  |   Pubmed ID: 21525976
• Protease Inhibitor Resistance Is Uncommon in HIV-1 Subtype C Infected Patients on Failing Second-Line Lopinavir/r-Containing Antiretroviral Therapy in South Africa
  AIDS Research and Treatment. 2011  |   Pubmed ID: 21490784
• HIV and Hepatitis Virus Resistance to Antivirals: Review of Data from the XIX International HIV and Hepatitis Virus Drug Resistance Workshop and Curative Strategies
  Antiviral Therapy. 2011  |   Pubmed ID: 21447877
• Failure of Initial Therapy with Two Nucleosides and Efavirenz is Not Associated with Early Emergence of Mutations in the C-terminus of HIV-1 Reverse Transcriptase
  Journal of Acquired Immune Deficiency Syndromes (1999). Apr, 2011  |   Pubmed ID: 21350368
• Genetic Diversity of Simian Immunodeficiency Virus Encoding HIV-1 Reverse Transcriptase Persists in Macaques Despite Antiretroviral Therapy
  Journal of Virology. Jan, 2011  |   Pubmed ID: 21084490
• A Randomized, Placebo-controlled Trial of Abacavir Intensification in HIV-1-infected Adults with Virologic Suppression on a Protease Inhibitor-containing Regimen
  HIV Clinical Trials. Nov-Dec, 2010  |   Pubmed ID: 21239359
• Antiretroviral Therapies in Women After Single-dose Nevirapine Exposure
  The New England Journal of Medicine. Oct, 2010  |   Pubmed ID: 20942666
• HIV-1 Continues to Replicate and Evolve in Patients with Natural Control of HIV Infection
  Journal of Virology. Dec, 2010  |   Pubmed ID: 20926564
• The Effect of Raltegravir Intensification on Low-level Residual Viremia in HIV-infected Patients on Antiretroviral Therapy: a Randomized Controlled Trial
  PLoS Medicine. 2010  |   Pubmed ID: 20711481
• Planning for Pre-exposure Prophylaxis to Prevent HIV Transmission: Challenges and Opportunities
  Journal of the International AIDS Society. 2010  |   Pubmed ID: 20624303
• Clonal Resistance Analyses of HIV Type-1 After Failure of Therapy with Didanosine, Lamivudine and Tenofovir
  Antiviral Therapy. 2010  |   Pubmed ID: 20516563
• A Pilot Study to Determine the Impact on Dyslipidemia of Adding Tenofovir to Stable Background Antiretroviral Therapy: ACTG 5206
  AIDS (London, England). Jul, 2010  |   Pubmed ID: 20495438
• Low Frequency Nonnucleoside Reverse-transcriptase Inhibitor-resistant Variants Contribute to Failure of Efavirenz-containing Regimens in Treatment- Experienced Patients
  The Journal of Infectious Diseases. Mar, 2010  |   Pubmed ID: 20102272
• Synthesis and Evaluation of 3'-azido-2',3'-dideoxypurine Nucleosides As Inhibitors of Human Immunodeficiency Virus
  Bioorganic & Medicinal Chemistry Letters. Jan, 2010  |   Pubmed ID: 19948402
• Optimization of Allele-specific PCR Using Patient-specific HIV Consensus Sequences for Primer Design
  Journal of Virological Methods. Mar, 2010  |   Pubmed ID: 19948190
• Varied Patterns of HIV-1 Drug Resistance on Failing First-line Antiretroviral Therapy in South Africa
  Journal of Acquired Immune Deficiency Syndromes (1999). Apr, 2010  |   Pubmed ID: 19801944
• Progress in Basic and Clinical Research on HIV Resistance: Report on the XVIII International HIV Drug Resistance Workshop
  Antiviral Therapy. 2009  |   Pubmed ID: 19918107
• RT-SHIV Subpopulation Dynamics in Infected Macaques During Anti-HIV Therapy
  Retrovirology. 2009  |   Pubmed ID: 19889213
• Anti-human Immunodeficiency Virus Activity, Cross-resistance, Cytotoxicity, and Intracellular Pharmacology of the 3'-azido-2',3'-dideoxypurine Nucleosides
  Antimicrobial Agents and Chemotherapy. Sep, 2009  |   Pubmed ID: 19596885
• Metabolic Outcomes in a Randomized Trial of Nucleoside, Nonnucleoside and Protease Inhibitor-sparing Regimens for Initial HIV Treatment
  AIDS (London, England). Jun, 2009  |   Pubmed ID: 19417580
• Simplification Strategies to Reduce Antiretroviral Drug Exposure: Progress and Prospects
  Antiviral Therapy. 2009  |   Pubmed ID: 19320232
• Regimen Simplification to Atazanavir-ritonavir Alone As Maintenance Antiretroviral Therapy: Final 48-week Clinical and Virologic Outcomes
  The Journal of Infectious Diseases. Mar, 2009  |   Pubmed ID: 19191590
• Single-dose Nevirapine to Prevent Mother-to-child Transmission of HIV Type 1: Balancing the Benefits and Risks
  Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. Feb, 2009  |   Pubmed ID: 19133800
• Antiretroviral Drug Resistance Testing in Adult HIV-1 Infection: 2008 Recommendations of an International AIDS Society-USA Panel
  Topics in HIV Medicine : a Publication of the International AIDS Society, USA. Aug-Sep, 2008  |   Pubmed ID: 19856548
• Broad Advances in Understanding HIV Resistance to Antiretrovirals: Report on the XVII International HIV Drug Resistance Workshop
  Antiviral Therapy. 2008  |   Pubmed ID: 19195337
• Mechanism by Which a Glutamine to Leucine Substitution at Residue 509 in the Ribonuclease H Domain of HIV-1 Reverse Transcriptase Confers Zidovudine Resistance
  Biochemistry. Dec, 2008  |   Pubmed ID: 19067547
• Lytic Granule Loading of CD8+ T Cells is Required for HIV-infected Cell Elimination Associated with Immune Control
  Immunity. Dec, 2008  |   Pubmed ID: 19062316
• YKL-40, a Marker of Simian Immunodeficiency Virus Encephalitis, Modulates the Biological Activity of Basic Fibroblast Growth Factor
  The American Journal of Pathology. Jul, 2008  |   Pubmed ID: 18556781
• Antiretroviral Drug Resistance Testing in Adult HIV-1 Infection: 2008 Recommendations of an International AIDS Society-USA Panel
  Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. Jul, 2008  |   Pubmed ID: 18549313
• Class-sparing Regimens for Initial Treatment of HIV-1 Infection
  The New England Journal of Medicine. May, 2008  |   Pubmed ID: 18480202
• Randomized Study of Dual Versus Single Ritonavir-enhanced Protease Inhibitors for Protease Inhibitor-experienced Patients with HIV
  HIV Clinical Trials. Mar-Apr, 2008  |   Pubmed ID: 18474494
• Low-level Viremia Persists for at Least 7 Years in Patients on Suppressive Antiretroviral Therapy
  Proceedings of the National Academy of Sciences of the United States of America. Mar, 2008  |   Pubmed ID: 18332425
• Frequent Polymorphism at Drug Resistance Sites in HIV-1 Protease and Reverse Transcriptase
  AIDS (London, England). Feb, 2008  |   Pubmed ID: 18301062
• Madurahydroxylactone Derivatives As Dual Inhibitors of Human Immunodeficiency Virus Type 1 Integrase and RNase H
  Antimicrobial Agents and Chemotherapy. Jan, 2008  |   Pubmed ID: 17967911
• Mechanisms by Which the G333D Mutation in Human Immunodeficiency Virus Type 1 Reverse Transcriptase Facilitates Dual Resistance to Zidovudine and Lamivudine
  Antimicrobial Agents and Chemotherapy. Jan, 2008  |   Pubmed ID: 17967907
• The Use of Beta-D-2,6-diaminopurine Dioxolane with or Without Mycophenolate Mofetil in Drug-resistant HIV Infection
  AIDS (London, England). Oct, 2007  |   Pubmed ID: 17885292
• Potential Impact of Antiretroviral Chemoprophylaxis on HIV-1 Transmission in Resource-limited Settings
  PloS One. 2007  |   Pubmed ID: 17878928
• Suppression of Viremia and Evolution of Human Immunodeficiency Virus Type 1 Drug Resistance in a Macaque Model for Antiretroviral Therapy
  Journal of Virology. Nov, 2007  |   Pubmed ID: 17855539
• Molecular Mechanisms of Bidirectional Antagonism Between K65R and Thymidine Analog Mutations in HIV-1 Reverse Transcriptase
  AIDS (London, England). Jul, 2007  |   Pubmed ID: 17589186
• Prognostic Value of HIV-1 RNA, CD4 Cell Count, and CD4 Cell Count Slope for Progression to AIDS and Death in Untreated HIV-1 Infection
  JAMA : the Journal of the American Medical Association. Jun, 2007  |   Pubmed ID: 17551128
• Selection of Mutations in the Connection and RNase H Domains of Human Immunodeficiency Virus Type 1 Reverse Transcriptase That Increase Resistance to 3'-azido-3'-dideoxythymidine
  Journal of Virology. Aug, 2007  |   Pubmed ID: 17507476
• ART Suppresses Plasma HIV-1 RNA to a Stable Set Point Predicted by Pretherapy Viremia
  PLoS Pathogens. Apr, 2007  |   Pubmed ID: 17411338
• No Cure Yet for HIV-1, but Therapeutic Research Presses On
  The Journal of Infectious Diseases. Mar, 2007  |   Pubmed ID: 17299705
• Molecular Mechanism by Which the K70E Mutation in Human Immunodeficiency Virus Type 1 Reverse Transcriptase Confers Resistance to Nucleoside Reverse Transcriptase Inhibitors
  Antimicrobial Agents and Chemotherapy. Jan, 2007  |   Pubmed ID: 17088490
• The Level of Persistent HIV Viremia Does Not Increase After Successful Simplification of Maintenance Therapy to Lopinavir/ritonavir Alone
  AIDS (London, England). Nov, 2006  |   Pubmed ID: 17117019
• A Randomized Trial of Treatment Interruption Before Optimized Antiretroviral Therapy for Persons with Drug-resistant HIV: 48-week Virologic Results of ACTG A5086
  The Journal of Infectious Diseases. Nov, 2006  |   Pubmed ID: 17041858
• Regimen Simplification to Atazanavir-ritonavir Alone As Maintenance Antiretroviral Therapy After Sustained Virologic Suppression
  JAMA : the Journal of the American Medical Association. Aug, 2006  |   Pubmed ID: 16905786
• Antagonism Between the HIV-1 Reverse-transcriptase Mutation K65R and Thymidine-analogue Mutations at the Genomic Level
  The Journal of Infectious Diseases. Sep, 2006  |   Pubmed ID: 16897664
• Blinded, Multicenter Comparison of Methods to Detect a Drug-resistant Mutant of Human Immunodeficiency Virus Type 1 at Low Frequency
  Journal of Clinical Microbiology. Jul, 2006  |   Pubmed ID: 16825395
• Potential Impact of Antiretroviral Therapy on HIV-1 Transmission and AIDS Mortality in Resource-limited Settings
  Journal of Acquired Immune Deficiency Syndromes (1999). Apr, 2006  |   Pubmed ID: 16652038
• The K65R Mutation in Human Immunodeficiency Virus Type 1 Reverse Transcriptase Exhibits Bidirectional Phenotypic Antagonism with Thymidine Analog Mutations
  Journal of Virology. May, 2006  |   Pubmed ID: 16641288
• Reverse Transcriptase Mutations 118I, 208Y, and 215Y Cause HIV-1 Hypersusceptibility to Non-nucleoside Reverse Transcriptase Inhibitors
  AIDS (London, England). Apr, 2006  |   Pubmed ID: 16603849
• Selection and Persistence of Non-nucleoside Reverse Transcriptase Inhibitor-resistant HIV-1 in Patients Starting and Stopping Non-nucleoside Therapy
  AIDS (London, England). Mar, 2006  |   Pubmed ID: 16514300
• Sensitive Phenotypic Detection of Minor Drug-resistant Human Immunodeficiency Virus Type 1 Reverse Transcriptase Variants
  Journal of Clinical Microbiology. Nov, 2005  |   Pubmed ID: 16272507
• In Vitro Selection and Analysis of Human Immunodeficiency Virus Type 1 Resistant to Derivatives of Beta-2',3'-didehydro-2',3'-dideoxy-5-fluorocytidine
  Antimicrobial Agents and Chemotherapy. Sep, 2005  |   Pubmed ID: 16127074
• Depletion of Latent HIV-1 Infection in Vivo: a Proof-of-concept Study
  Lancet. Aug 13-19, 2005  |   Pubmed ID: 16099290
• The 3'-azido Group is Not the Primary Determinant of 3'-azido-3'-deoxythymidine (AZT) Responsible for the Excision Phenotype of AZT-resistant HIV-1
  The Journal of Biological Chemistry. Aug, 2005  |   Pubmed ID: 15970587
• In Vitro Activity of Structurally Diverse Nucleoside Analogs Against Human Immunodeficiency Virus Type 1 with the K65R Mutation in Reverse Transcriptase
  Antimicrobial Agents and Chemotherapy. Mar, 2005  |   Pubmed ID: 15728915
• Mechanism for Nucleoside Analog-mediated Abrogation of HIV-1 Replication: Balance Between RNase H Activity and Nucleotide Excision
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2005  |   Pubmed ID: 15684061
• Combining Fosamprenavir with Lopinavir/ritonavir Substantially Reduces Amprenavir and Lopinavir Exposure: ACTG Protocol A5143 Results
  AIDS (London, England). Jan, 2005  |   Pubmed ID: 15668539
• Multiple, Linked Human Immunodeficiency Virus Type 1 Drug Resistance Mutations in Treatment-experienced Patients Are Missed by Standard Genotype Analysis
  Journal of Clinical Microbiology. Jan, 2005  |   Pubmed ID: 15635002
• Prognostic Value of Plasma HIV RNA Among Highly Active Antiretroviral Therapy Users
  AIDS (London, England). Dec, 2004  |   Pubmed ID: 15622318
• Genetic Correlates of Efavirenz Hypersusceptibility
  AIDS (London, England). Sep, 2004  |   Pubmed ID: 15316338
• Hybrids of [TSAO-T]-[foscarnet]: The First Conjugate of Foscarnet with a Non-nucleoside Reverse Transcriptase Inhibitor Through a Labile Covalent Ester Bond
  Journal of Medicinal Chemistry. Jun, 2004  |   Pubmed ID: 15189038
• A Randomized Trial of Nelfinavir and Abacavir in Combination with Efavirenz and Adefovir Dipivoxil in HIV-1-infected Persons with Virological Failure Receiving Indinavir
  Antiviral Therapy. Dec, 2003  |   Pubmed ID: 14760884
• Six-year Follow-up of HIV-1-infected Adults in a Clinical Trial of Antiretroviral Therapy with Indinavir, Zidovudine, and Lamivudine
  AIDS (London, England). Nov, 2003  |   Pubmed ID: 14571186
• New Real-time Reverse Transcriptase-initiated PCR Assay with Single-copy Sensitivity for Human Immunodeficiency Virus Type 1 RNA in Plasma
  Journal of Clinical Microbiology. Oct, 2003  |   Pubmed ID: 14532178
• Questions to and Answers from the International AIDS Society-USA Resistance Testing Guidelines Panel
  Topics in HIV Medicine : a Publication of the International AIDS Society, USA. Jul-Aug, 2003  |   Pubmed ID: 12876334
• Antiretroviral Drug Resistance Testing in Adults Infected with Human Immunodeficiency Virus Type 1: 2003 Recommendations of an International AIDS Society-USA Panel
  Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. Jul, 2003  |   Pubmed ID: 12830416
• Relationship Between 3'-azido-3'-deoxythymidine Resistance and Primer Unblocking Activity in Foscarnet-resistant Mutants of Human Immunodeficiency Virus Type 1 Reverse Transcriptase
  Journal of Virology. Jun, 2003  |   Pubmed ID: 12743270
• Accuracy of the TRUGENE HIV-1 Genotyping Kit
  Journal of Clinical Microbiology. Apr, 2003  |   Pubmed ID: 12682149
• Virologic and Immunologic Values Allowing Safe Deferral of Antiretroviral Therapy
  AIDS (London, England). Dec, 2002  |   Pubmed ID: 12461420
• Interruption of Antiretroviral Therapy to Augment Immune Control of Chronic HIV-1 Infection: Risk Without Reward
  Proceedings of the National Academy of Sciences of the United States of America. Oct, 2002  |   Pubmed ID: 12370421
• Antiretroviral-drug Resistance Among Patients Recently Infected with HIV
  The New England Journal of Medicine. Aug, 2002  |   Pubmed ID: 12167680
• Dual Vs Single Protease Inhibitor Therapy Following Antiretroviral Treatment Failure: a Randomized Trial
  JAMA : the Journal of the American Medical Association. Jul, 2002  |   Pubmed ID: 12095381
• Effects of Specific Zidovudine Resistance Mutations and Substrate Structure on Nucleotide-dependent Primer Unblocking by Human Immunodeficiency Virus Type 1 Reverse Transcriptase
  Antimicrobial Agents and Chemotherapy. May, 2002  |   Pubmed ID: 11959594
• Recovery of Replication-competent HIV Type 1-infected Circulating Monocytes from Individuals Receiving Antiretroviral Therapy
  AIDS Research and Human Retroviruses. Apr, 2002  |   Pubmed ID: 11958686
• Predictive Value of Immunologic and Virologic Markers After Long or Short Duration of HIV-1 Infection
  Journal of Acquired Immune Deficiency Syndromes (1999). Apr, 2002  |   Pubmed ID: 11917238