Jonas Klingström Center for Infectious Medicine, Department of Medicine Huddinge Karolinska Institutet Biography Publications Institution JoVE Articles Jonas Klingström has not added a biography. If you are Jonas Klingström and would like to personalize this page please email our Author Liaison for assistance. Publications Humoral Immune Responses to the Monovalent XBB.1.5-adapted BNT162b2 MRNA Booster in Sweden The Lancet. Infectious Diseases. Jan, 2024 | Pubmed ID: 38190833 SARS-CoV-2 Variant-specific Differences in Inhibiting the Effects of the PKR-activated Integrated Stress Response Virus Research. Jan, 2024 | Pubmed ID: 37979658 Dynamic MAIT Cell Recovery After Severe COVID-19 Is Transient with Signs of Heterogeneous Functional Anomalies Journal of Immunology (Baltimore, Md. : 1950). Dec, 2023 | Pubmed ID: 38117799 Mucosal and Serum Antibodies 3 Weeks After Symptomatic BA.2.86 Infection The New England Journal of Medicine. Oct, 2023 | Pubmed ID: 37888924 Comprehensive Proteomics and Meta-analysis of COVID-19 Host Response Nature Communications. Sep, 2023 | Pubmed ID: 37739942 SARS-CoV-2-related Mortality Decrease in Nursing Home Residents Given Multiple COVID-19 Boosters The Lancet. Infectious Diseases. Oct, 2023 | Pubmed ID: 37716359 Point Prevalence of SARS-CoV-2 Infection Among Healthcare Workers in March and June 2023 in Sweden The Lancet Regional Health. Europe. Oct, 2023 | Pubmed ID: 37680234 Super-resolution Proximity Labeling Reveals Anti-viral Protein Network and Its Structural Changes Against SARS-CoV-2 Viral Proteins Cell Reports. Aug, 2023 | Pubmed ID: 37478010 Mucosal IgA Protects Against BQ.1 and BQ.1.1 Infection The Lancet. Infectious Diseases. Aug, 2023 | Pubmed ID: 37453441 Vaccine-induced Correlate of Protection Against Fatal COVID-19 in Older and Frail Adults During Waves of Neutralization-resistant Variants of Concern: an Observational Study The Lancet Regional Health. Europe. May, 2023 | Pubmed ID: 37363799 High Prevalence of SARS-CoV-2 Omicron Infection Despite High Seroprevalence, Sweden, 2022 Emerging Infectious Diseases. Jun, 2023 | Pubmed ID: 37141616 Hantavirus in Humans: a Review of Clinical Aspects and Management The Lancet. Infectious Diseases. Sep, 2023 | Pubmed ID: 37105214 Mucosal Immune Responses Following a Fourth SARS-CoV-2 Vaccine Dose The Lancet. Microbe. Jul, 2023 | Pubmed ID: 37086736 Delayed Generation of Functional Virus-specific Circulating T Follicular Helper Cells Correlates with Severe COVID-19 Nature Communications. Apr, 2023 | Pubmed ID: 37061513 Correlates of Protection and Viral Load Trajectories in Omicron Breakthrough Infections in Triple Vaccinated Healthcare Workers Nature Communications. Mar, 2023 | Pubmed ID: 36949041 Targeted Plasma Proteomics Reveals Signatures Discriminating COVID-19 from Sepsis with Pneumonia Respiratory Research. Feb, 2023 | Pubmed ID: 36829233 Safety and Immunogenicity Following Co-administration of Yellow Fever Vaccine with Tick-borne Encephalitis or Japanese Encephalitis Vaccines: Results from an Open Label, Non-randomized Clinical Trial PLoS Neglected Tropical Diseases. Feb, 2023 | Pubmed ID: 36758067 7-month Duration of SARS-CoV-2 Mucosal Immunoglobulin-A Responses and Protection The Lancet. Infectious Diseases. Feb, 2023 | Pubmed ID: 36640796 Rapid Emergence of Omicron Sublineages Expressing Spike Protein R346T The Lancet Regional Health. Europe. Jan, 2023 | Pubmed ID: 36533118 2022 Taxonomic Update of Phylum Negarnaviricota (Riboviria: Orthornavirae), Including the Large Orders Bunyavirales and Mononegavirales Archives of Virology. Dec, 2022 | Pubmed ID: 36437428 Anti-Spike Mucosal IgA Protection Against SARS-CoV-2 Omicron Infection The New England Journal of Medicine. Oct, 2022 | Pubmed ID: 36103621 Infection Rate of SARS-CoV-2 in Asymptomatic Healthcare Workers, Sweden, June 2022 Emerging Infectious Diseases. Oct, 2022 | Pubmed ID: 35997692 Clinical Grade ACE2 As a Universal Agent to Block SARS-CoV-2 Variants EMBO Molecular Medicine. Aug, 2022 | Pubmed ID: 35781796 Deaths from Tick-Borne Encephalitis, Sweden Emerging Infectious Diseases. Jul, 2022 | Pubmed ID: 35731187 Immune Responses After Omicron Infection in Triple-vaccinated Health-care Workers with and Without Previous SARS-CoV-2 Infection The Lancet. Infectious Diseases. Jul, 2022 | Pubmed ID: 35691303 The Karolinska KI/K COVID-19 Immune Atlas: An Open Resource for Immunological Research and Educational Purposes Scandinavian Journal of Immunology. Jun, 2022 | Pubmed ID: 35652743 Neutralizing SARS-CoV-2 Antibodies in Commercial Immunoglobulin Products Give Patients with X-Linked Agammaglobulinemia Limited Passive Immunity to the Omicron Variant Journal of Clinical Immunology. Aug, 2022 | Pubmed ID: 35538387 Impact of SARS-CoV-2 Infection on Vaccine-induced Immune Responses over Time Clinical & Translational Immunology. 2022 | Pubmed ID: 35444806 Duration of SARS-CoV-2 Immune Responses Up to Six Months Following Homologous or Heterologous Primary Immunization with ChAdOx1 NCoV-19 and BNT162b2 MRNA Vaccines Vaccines. Feb, 2022 | Pubmed ID: 35334989 Broad Anti-SARS-CoV-2 Antibody Immunity Induced by Heterologous ChAdOx1/mRNA-1273 Vaccination Science (New York, N.Y.). Mar, 2022 | Pubmed ID: 35143256 COVID-19-specific Metabolic Imprint Yields Insights into Multiorgan System Perturbations European Journal of Immunology. Mar, 2022 | Pubmed ID: 34837225 A Cell-free High Throughput Assay for Assessment of SARS-CoV-2 Neutralizing Antibodies New Biotechnology. Jan, 2022 | Pubmed ID: 34628049 Robust Humoral and Cellular Immune Responses and Low Risk for Reinfection at Least 8 Months Following Asymptomatic to Mild COVID-19 Journal of Internal Medicine. Jan, 2022 | Pubmed ID: 34459525 Correction To: 2021 Taxonomic Update of Phylum Negarnaviricota (Riboviria: Orthornavirae), Including the Large Orders Bunyavirales and Mononegavirales Archives of Virology. Dec, 2021 | Pubmed ID: 34786611 Association Between Haemorrhagic Fever with Renal Syndrome and Cancers International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases. Dec, 2021 | Pubmed ID: 34653656 A Flow Cytometry-based Proliferation Assay for Clinical Evaluation of T-cell Memory Against SARS-CoV-2 Journal of Immunological Methods. Dec, 2021 | Pubmed ID: 34597619 High-dimensional Profiling Reveals Phenotypic Heterogeneity and Disease-specific Alterations of Granulocytes in COVID-19 Proceedings of the National Academy of Sciences of the United States of America. Oct, 2021 | Pubmed ID: 34548411 2021 Taxonomic Update of Phylum Negarnaviricota (Riboviria: Orthornavirae), Including the Large Orders Bunyavirales and Mononegavirales Archives of Virology. Dec, 2021 | Pubmed ID: 34463877 Antibody Responses After a Single Dose of ChAdOx1 NCoV-19 Vaccine in Healthcare Workers Previously Infected with SARS-CoV-2 EBioMedicine. Aug, 2021 | Pubmed ID: 34391088 Systematic Evaluation of SARS-CoV-2 Antigens Enables a Highly Specific and Sensitive Multiplex Serological COVID-19 Assay Clinical & Translational Immunology. 2021 | Pubmed ID: 34295471 Generation of Plasma Cells and CD27IgD B Cells During Hantavirus Infection is Associated with Distinct Pathological Findings Clinical & Translational Immunology. 2021 | Pubmed ID: 34277007 Heterologous ChAdOx1 NCoV-19 and MRNA-1273 Vaccination The New England Journal of Medicine. Sep, 2021 | Pubmed ID: 34260850 SARS-CoV-2-specific Humoral and Cellular Immunity Persists Through 9 Months Irrespective of COVID-19 Severity at Hospitalisation Clinical & Translational Immunology. 2021 | Pubmed ID: 34257967 Genetic Depletion Studies Inform Receptor Usage by Virulent Hantaviruses in Human Endothelial Cells ELife. Jul, 2021 | Pubmed ID: 34232859 Shedding of Infectious SARS-CoV-2 by Hospitalized COVID-19 Patients in Relation to Serum Antibody Responses BMC Infectious Diseases. May, 2021 | Pubmed ID: 34044758 RT-qPCR Assay for Detection of Mink Astrovirus in Outbreaks of Diarrhea on Danish Mink Farms PloS One. 2021 | Pubmed ID: 34038467 Evaluation of 11 SARS-CoV-2 Antibody Tests by Using Samples from Patients with Defined IgG Antibody Titers Scientific Reports. Apr, 2021 | Pubmed ID: 33828214 MAIT Cell Activation is Associated with Disease Severity Markers in Acute Hantavirus Infection Cell Reports. Medicine. Mar, 2021 | Pubmed ID: 33763658 Monocyte Subset Redistribution from Blood to Kidneys in Patients with Puumala Virus Caused Hemorrhagic Fever with Renal Syndrome PLoS Pathogens. Mar, 2021 | Pubmed ID: 33690725 Major Alterations in the Mononuclear Phagocyte Landscape Associated with COVID-19 Severity Proceedings of the National Academy of Sciences of the United States of America. Feb, 2021 | Pubmed ID: 33479167 Innate Lymphoid Cell Composition Associates with COVID-19 Disease Severity Clinical & Translational Immunology. 2020 | Pubmed ID: 33343897 MAIT Cell Activation and Dynamics Associated with COVID-19 Disease Severity Science Immunology. Sep, 2020 | Pubmed ID: 32989174 Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19 Cell. Oct, 2020 | Pubmed ID: 32979941 2020 Taxonomic Update for Phylum Negarnaviricota (Riboviria: Orthornavirae), Including the Large Orders Bunyavirales and Mononegavirales Archives of Virology. Dec, 2020 | Pubmed ID: 32888050 Expansion of SARS-CoV-2-Specific Antibody-Secreting Cells and Generation of Neutralizing Antibodies in Hospitalized COVID-19 Patients Journal of Immunology (Baltimore, Md. : 1950). Nov, 2020 | Pubmed ID: 32878912 Natural Killer Cell Immunotypes Related to COVID-19 Disease Severity Science Immunology. Aug, 2020 | Pubmed ID: 32826343 Meeting Report: Eleventh International Conference on Hantaviruses Antiviral Research. Apr, 2020 | Pubmed ID: 32068071 Hantavirus Inhibits Apoptosis by Preventing Mitochondrial Membrane Potential Loss Through Up-regulation of the Pro-survival Factor BCL-2 PLoS Pathogens. Feb, 2020 | Pubmed ID: 32032391 Puumala and Andes Orthohantaviruses Cause Transient Protein Kinase R-Dependent Formation of Stress Granules Journal of Virology. Jan, 2020 | Pubmed ID: 31723021 NK Cells Are Activated and Primed for Skin-homing During Acute Dengue Virus Infection in Humans Nature Communications. Aug, 2019 | Pubmed ID: 31467285 : Current Classification and Future Perspectives Viruses. Aug, 2019 | Pubmed ID: 31461937 Hantavirus Inhibits TRAIL-Mediated Killing of Infected Cells by Downregulating Death Receptor 5 Cell Reports. Aug, 2019 | Pubmed ID: 31433987 Taxonomy of the Order Bunyavirales: Update 2019 Archives of Virology. Jul, 2019 | Pubmed ID: 31065850 Serum Markers Associated with Severity and Outcome of Hantavirus Pulmonary Syndrome The Journal of Infectious Diseases. May, 2019 | Pubmed ID: 30698699 Orthohantaviruses Belonging to Three Phylogroups All Inhibit Apoptosis in Infected Target Cells Scientific Reports. Jan, 2019 | Pubmed ID: 30696898 Taxonomy of the Order Bunyavirales: Second Update 2018 Archives of Virology. Mar, 2019 | Pubmed ID: 30663021 Strengthening the Interaction of the Virology Community with the International Committee on Taxonomy of Viruses (ICTV) by Linking Virus Names and Their Abbreviations to Virus Species Systematic Biology. 09, 2019 | Pubmed ID: 30597118 Cell-Mediated Immune Responses and Immunopathogenesis of Human Tick-Borne Encephalitis Virus-Infection Frontiers in Immunology. 2018 | Pubmed ID: 30319632 Risk of Venous Thromboembolism Following Hemorrhagic Fever With Renal Syndrome: A Self-controlled Case Series Study Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. Jan, 2018 | Pubmed ID: 29020303 Human Hantavirus Infection Elicits Pronounced Redistribution of Mononuclear Phagocytes in Peripheral Blood and Airways PLoS Pathogens. Jun, 2017 | Pubmed ID: 28640917 Molecular Diagnosis of Hemorrhagic Fever with Renal Syndrome Caused by Puumala Virus Journal of Clinical Microbiology. May, 2016 | Pubmed ID: 26962084 Interferons Induce STAT1-Dependent Expression of Tissue Plasminogen Activator, a Pathogenicity Factor in Puumala Hantavirus Disease The Journal of Infectious Diseases. May, 2016 | Pubmed ID: 26704613 Specificity and Dynamics of Effector and Memory CD8 T Cell Responses in Human Tick-borne Encephalitis Virus Infection PLoS Pathogens. Jan, 2015 | Pubmed ID: 25611738 NK Cell Activation in Human Hantavirus Infection Explained by Virus-induced IL-15/IL15Rα Expression PLoS Pathogens. Nov, 2014 | Pubmed ID: 25412359 Acute Hantavirus Infection Induces Galectin-3-binding Protein The Journal of General Virology. Nov, 2014 | Pubmed ID: 25013204 Increased Risk for Lymphoma Following Hemorrhagic Fever with Renal Syndrome Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. Oct, 2014 | Pubmed ID: 24965350 Increased Risk of Acute Myocardial Infarction and Stroke During Hemorrhagic Fever with Renal Syndrome: a Self-controlled Case Series Study Circulation. Mar, 2014 | Pubmed ID: 24398017 Hantavirus Gn and Gc Glycoproteins Self-assemble into Virus-like Particles Journal of Virology. Feb, 2014 | Pubmed ID: 24335294 Hantavirus-infection Confers Resistance to Cytotoxic Lymphocyte-mediated Apoptosis PLoS Pathogens. Mar, 2013 | Pubmed ID: 23555267 Human Herpesvirus 6A Partially Suppresses Functional Properties of DC Without Viral Replication PloS One. 2013 | Pubmed ID: 23526966 Puumala Virus Infections Associated with Cardiovascular Causes of Death Emerging Infectious Diseases. Jan, 2013 | Pubmed ID: 23260342 A Model System for in Vitro Studies of Bank Vole Borne Viruses PloS One. 2011 | Pubmed ID: 22194969 Rapid Expansion and Long-term Persistence of Elevated NK Cell Numbers in Humans Infected with Hantavirus The Journal of Experimental Medicine. Jan, 2011 | Pubmed ID: 21173105 Characterization of Two Substrains of Puumala Virus That Show Phenotypes That Are Different from Each Other and from the Original Strain Journal of Virology. Feb, 2011 | Pubmed ID: 21106742 Mortality Rate Patterns for Hemorrhagic Fever with Renal Syndrome Caused by Puumala Virus Emerging Infectious Diseases. Oct, 2010 | Pubmed ID: 20875284 Alpha/beta Interferon (IFN-alpha/beta)-independent Induction of IFN-lambda1 (interleukin-29) in Response to Hantaan Virus Infection Journal of Virology. Sep, 2010 | Pubmed ID: 20592090 Sensitivity of Andes Hantavirus to Antiviral Effect of Human Saliva Emerging Infectious Diseases. Jul, 2009 | Pubmed ID: 19624946 Antiviral Effect of Human Saliva Against Hantavirus Journal of Medical Virology. Dec, 2008 | Pubmed ID: 19040288 Pathology of Puumala Hantavirus Infection in Macaques PloS One. Aug, 2008 | Pubmed ID: 18716663 Puumala Hantavirus Excretion Kinetics in Bank Voles (Myodes Glareolus) Emerging Infectious Diseases. Aug, 2008 | Pubmed ID: 18680643 Processing of Genome 5' Termini As a Strategy of Negative-strand RNA Viruses to Avoid RIG-I-dependent Interferon Induction PloS One. 2008 | Pubmed ID: 18446221 Sex-dependent Differences in Plasma Cytokine Responses to Hantavirus Infection Clinical and Vaccine Immunology : CVI. May, 2008 | Pubmed ID: 18353922 Hantavirus RNA in Saliva from Patients with Hemorrhagic Fever with Renal Syndrome Emerging Infectious Diseases. Mar, 2008 | Pubmed ID: 18325254 Lambda Interferon (IFN-lambda) in Serum is Decreased in Hantavirus-infected Patients, and in Vitro-established Infection is Insensitive to Treatment with All IFNs and Inhibits IFN-gamma-induced Nitric Oxide Production Journal of Virology. Aug, 2007 | Pubmed ID: 17522204 Nitric Oxide and Peroxynitrite Have Different Antiviral Effects Against Hantavirus Replication and Free Mature Virions European Journal of Immunology. Oct, 2006 | Pubmed ID: 16955520 Loss of Cell Membrane Integrity in Puumala Hantavirus-infected Patients Correlates with Levels of Epithelial Cell Apoptosis and Perforin Journal of Virology. Aug, 2006 | Pubmed ID: 16873286 Prolonged Survival of Puumala Hantavirus Outside the Host: Evidence for Indirect Transmission Via the Environment The Journal of General Virology. Aug, 2006 | Pubmed ID: 16847107 Dobrava, but Not Saaremaa, Hantavirus is Lethal and Induces Nitric Oxide Production in Suckling Mice Microbes and Infection. Mar, 2006 | Pubmed ID: 16513381 Nitric Oxide Inhibits the Replication Cycle of Severe Acute Respiratory Syndrome Coronavirus Journal of Virology. Feb, 2005 | Pubmed ID: 15650225 Vaccination of C57/BL6 Mice with Dobrava Hantavirus Nucleocapsid Protein in Freund's Adjuvant Induced Partial Protection Against Challenge Vaccine. Sep, 2004 | Pubmed ID: 15364453 Author Spotlight: Advancing Antiviral Strategies through Novel Immunocapture and Mass Spectrometry Techniques Maryam Sahi1, Sarah Andersson1, Cecilia Mattson1, Matilda Dale1, Sofia Kagiolglou1, Camilla Hofström2, Helena Persson2, Jonas Klingström3,4, Francesca Chiodi5, Claudia Fredolini1 1Affinity Proteomics-Stockholm Unit, SciLifeLab, Division of Affinity Proteomics, Department of Protein Science, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), KTH Royal Institute of Technology, 2Human Antibody Therapeutics Unit, SciLifeLab, Division of Drug Discovery and Development, Department of Protein Science, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), KTH Royal Institute of Technology, 3Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, 4Public Health Agency of Sweden, 5Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet JoVE 66230 Immunology and Infection
Author Spotlight: Advancing Antiviral Strategies through Novel Immunocapture and Mass Spectrometry Techniques Maryam Sahi1, Sarah Andersson1, Cecilia Mattson1, Matilda Dale1, Sofia Kagiolglou1, Camilla Hofström2, Helena Persson2, Jonas Klingström3,4, Francesca Chiodi5, Claudia Fredolini1 1Affinity Proteomics-Stockholm Unit, SciLifeLab, Division of Affinity Proteomics, Department of Protein Science, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), KTH Royal Institute of Technology, 2Human Antibody Therapeutics Unit, SciLifeLab, Division of Drug Discovery and Development, Department of Protein Science, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), KTH Royal Institute of Technology, 3Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, 4Public Health Agency of Sweden, 5Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet JoVE 66230 Immunology and Infection