Juan Fortea Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau Universitat Autònoma de Barcelona Biography Publications Institution JoVE Articles Juan Fortea has not added a biography. If you are Juan Fortea and would like to personalize this page please email our Author Liaison for assistance. Publications Network Tau Spreading is Vulnerable to the Expression Gradients of and Glutamatergic-related Genes Science Translational Medicine. Jul, 2022 | Pubmed ID: 35895837 Myelin Loss in C9orf72 Hexanucleotide Expansion Carriers Journal of Neuroscience Research. Jun, 2022 | Pubmed ID: 35766328 DYRK1A and Activity-Dependent Neuroprotective Protein Comparative Diagnosis Interest in Cerebrospinal Fluid and Plasma in the Context of Alzheimer-Related Cognitive Impairment in Down Syndrome Patients Biomedicines. Jun, 2022 | Pubmed ID: 35740400 Association of Alzheimer Disease With Life Expectancy in People With Down Syndrome JAMA Network Open. 05, 2022 | Pubmed ID: 35604690 Diagnostic Accuracy of Magnetic Resonance Imaging Measures of Brain Atrophy Across the Spectrum of Progressive Supranuclear Palsy and Corticobasal Degeneration JAMA Network Open. 04, 2022 | Pubmed ID: 35486397 Mechanisms Involved in Epileptogenesis in Alzheimer's Disease and Their Therapeutic Implications International Journal of Molecular Sciences. Apr, 2022 | Pubmed ID: 35457126 Feasibility and Long-Term Compliance to Continuous Positive Airway Pressure Treatment in Adults With Down Syndrome, a Genetic Form of Alzheimer's Disease Frontiers in Neuroscience. 2022 | Pubmed ID: 35431793 Multimarker Synaptic Protein Cerebrospinal Fluid Panels Reflect TDP-43 Pathology and Cognitive Performance in a Pathological Cohort of Frontotemporal Lobar Degeneration Molecular Neurodegeneration. 04, 2022 | Pubmed ID: 35395770 New Insights into the Genetic Etiology of Alzheimer's Disease and Related Dementias Nature Genetics. 04, 2022 | Pubmed ID: 35379992 Conducting Clinical Trials in Persons with Down Syndrome: Summary from the NIH INCLUDE Down Syndrome Clinical Trials Readiness Working Group Journal of Neurodevelopmental Disorders. 03, 2022 | Pubmed ID: 35321660 Blood Amyloid and Tau Biomarkers As Predictors of Cerebrospinal Fluid Profiles Journal of Neural Transmission (Vienna, Austria : 1996). 02, 2022 | Pubmed ID: 35169889 Cortical Microstructure in Primary Progressive Aphasia: a Multicenter Study Alzheimer's Research & Therapy. 02, 2022 | Pubmed ID: 35139897 Hypothalamic Pregnenolone Mediates Recognition Memory in the Context of Metabolic Disorders Cell Metabolism. 02, 2022 | Pubmed ID: 35108514 The Aβ1-42/Aβ1-40 Ratio in CSF is More Strongly Associated to Tau Markers and Clinical Progression Than Aβ1-42 Alone Alzheimer's Research & Therapy. 02, 2022 | Pubmed ID: 35105351 Neuropathology of a Patient with Alzheimer Disease Treated with Low Doses of Verubecestat Neuropathology and Applied Neurobiology. 04, 2022 | Pubmed ID: 34825396 Risk of Intracranial Haemorrhage and Ischaemic Stroke After Convexity Subarachnoid Haemorrhage in Cerebral Amyloid Angiopathy: International Individual Patient Data Pooled Analysis Journal of Neurology. Mar, 2022 | Pubmed ID: 34272978 Pathophysiological Underpinnings of Extra-Motor Neurodegeneration in Amyotrophic Lateral Sclerosis: New Insights From Biomarker Studies Frontiers in Neurology. 2021 | Pubmed ID: 35115992 Plasma Glial Fibrillary Acidic Protein and Neurofilament Light Chain for the Diagnostic and Prognostic Evaluation of Frontotemporal Dementia Translational Neurodegeneration. 12, 2021 | Pubmed ID: 34893073 Alzheimer's Disease Associated with Down Syndrome: a Genetic Form of Dementia The Lancet. Neurology. 11, 2021 | Pubmed ID: 34687637 The Clinical and Neuropathological Features of Sporadic (Late-Onset) and Genetic Forms of Alzheimer's Disease Journal of Clinical Medicine. Oct, 2021 | Pubmed ID: 34640600 Association of Cortical Microstructure with Amyloid-β and Tau: Impact on Cognitive Decline, Neurodegeneration, and Clinical Progression in Older Adults Molecular Psychiatry. 12, 2021 | Pubmed ID: 34588623 Regional Grey Matter Microstructural Changes and Volume Loss According to Disease Duration in Multiple Sclerosis Patients Scientific Reports. 08, 2021 | Pubmed ID: 34413373 Metabolite Signature of Alzheimer's Disease in Adults with Down Syndrome Annals of Neurology. 09, 2021 | Pubmed ID: 34309066 Diagnostic and Prognostic Performance and Longitudinal Changes in Plasma Neurofilament Light Chain Concentrations in Adults with Down Syndrome: a Cohort Study The Lancet. Neurology. 08, 2021 | Pubmed ID: 34302785 Sleep Disorders in Adults with Down Syndrome Journal of Clinical Medicine. Jul, 2021 | Pubmed ID: 34300177 Opportunities, Barriers, and Recommendations in Down Syndrome Research Translational Science of Rare Diseases. 2021 | Pubmed ID: 34268067 Phosphorylated Tau181 in Plasma As a Potential Biomarker for Alzheimer's Disease in Adults with Down Syndrome Nature Communications. 07, 2021 | Pubmed ID: 34262030 Association of Apolipoprotein E ɛ4 Allele With Clinical and Multimodal Biomarker Changes of Alzheimer Disease in Adults With Down Syndrome JAMA Neurology. 08, 2021 | Pubmed ID: 34228042 Epilepsy in Down Syndrome: A Highly Prevalent Comorbidity Journal of Clinical Medicine. Jun, 2021 | Pubmed ID: 34202784 Use of Plasma Biomarkers for AT(N) Classification of Neurodegenerative Dementias Journal of Neurology, Neurosurgery, and Psychiatry. 11, 2021 | Pubmed ID: 34103344 Common Variants in Alzheimer's Disease and Risk Stratification by Polygenic Risk Scores Nature Communications. 06, 2021 | Pubmed ID: 34099642 AMYQ: An Index to Standardize Quantitative Amyloid Load Across PET Tracers Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 09, 2021 | Pubmed ID: 33797846 Diagnostic Utility of Measuring Cerebral Atrophy in the Behavioral Variant of Frontotemporal Dementia and Association With Clinical Deterioration JAMA Network Open. 03, 2021 | Pubmed ID: 33704477 Sex Differences in the Behavioral Variant of Frontotemporal Dementia: A New Window to Executive and Behavioral Reserve Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 08, 2021 | Pubmed ID: 33590953 Genome Sequencing Analysis Identifies New Loci Associated with Lewy Body Dementia and Provides Insights into Its Genetic Architecture Nature Genetics. 03, 2021 | Pubmed ID: 33589841 Plasma Total-Tau and Neurofilament Light Chain As Diagnostic Biomarkers of Alzheimer's Disease Dementia and Mild Cognitive Impairment in Adults with Down Syndrome Journal of Alzheimer's Disease : JAD. 2021 | Pubmed ID: 33337378 White Matter Hyperintensities Are No Major Confounder for Alzheimer's Disease Cerebrospinal Fluid Biomarkers Journal of Alzheimer's Disease : JAD. 2021 | Pubmed ID: 33252070 Nerve Growth Factor (NGF) Pathway Biomarkers in Down Syndrome Prior to and After the Onset of Clinical Alzheimer's Disease: A Paired CSF and Plasma Study Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 04, 2021 | Pubmed ID: 33226181 Biphasic Cortical Macro- and Microstructural Changes in Autosomal Dominant Alzheimer's Disease Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 04, 2021 | Pubmed ID: 33196147 Distinctive Oculomotor Behaviors in Alzheimer's Disease and Frontotemporal Dementia Frontiers in Aging Neuroscience. 2020 | Pubmed ID: 33613262 Cortical Microstructure in the Amyotrophic Lateral Sclerosis-frontotemporal Dementia Continuum Neurology. 11, 2020 | Pubmed ID: 32913016 Evaluation of Biochemical and Hematological Parameters in Adults with Down Syndrome Scientific Reports. 08, 2020 | Pubmed ID: 32792619 Obesity Impacts Brain Metabolism and Structure Independently of Amyloid and Tau Pathology in Healthy Elderly Alzheimer's & Dementia (Amsterdam, Netherlands). 2020 | Pubmed ID: 32743041 Motor Cortex Transcriptome Reveals Microglial Key Events in Amyotrophic Lateral Sclerosis Neurology(R) Neuroimmunology & Neuroinflammation. 09, 2020 | Pubmed ID: 32669313 Clinical and Biomarker Changes of Alzheimer's Disease in Adults with Down Syndrome: a Cross-sectional Study Lancet (London, England). 06, 2020 | Pubmed ID: 32593336 COVID-19-associated Ophthalmoparesis and Hypothalamic Involvement Neurology(R) Neuroimmunology & Neuroinflammation. 09, 2020 | Pubmed ID: 32587102 Further Understanding the Connection Between Alzheimer's Disease and Down Syndrome Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 07, 2020 | Pubmed ID: 32544310 Cortical Microstructural Correlates of Astrocytosis in Autosomal-dominant Alzheimer Disease Neurology. 05, 2020 | Pubmed ID: 32291295 Correction To: A Nonsynonymous Mutation in PLCG2 Reduces the Risk of Alzheimer's Disease, Dementia with Lewy Bodies and Frontotemporal Dementia, and Increases the Likelihood of Longevity Acta Neuropathologica. 05, 2020 | Pubmed ID: 31955222 Atrophy of Basal Forebrain Initiates with Tau Pathology in Individuals at Risk for Alzheimer's Disease Cerebral Cortex (New York, N.Y. : 1991). 04, 2020 | Pubmed ID: 31799623 Detection of Amyloid Beta Peptides in Body Fluids for the Diagnosis of Alzheimer's Disease: Where Do We Stand? Critical Reviews in Clinical Laboratory Sciences. 03, 2020 | Pubmed ID: 31661652 APP-derived Peptides Reflect Neurodegeneration in Frontotemporal Dementia Annals of Clinical and Translational Neurology. 12, 2019 | Pubmed ID: 31789459 The Sant Pau Initiative on Neurodegeneration (SPIN) Cohort: A Data Set for Biomarker Discovery and Validation in Neurodegenerative Disorders Alzheimer's & Dementia (New York, N. Y.). 2019 | Pubmed ID: 31650016 Trisomy 21 Activates the Kynurenine Pathway Via Increased Dosage of Interferon Receptors Nature Communications. 10, 2019 | Pubmed ID: 31628327 Assessing General Cognitive and Adaptive Abilities in Adults with Down Syndrome: a Systematic Review Journal of Neurodevelopmental Disorders. 08, 2019 | Pubmed ID: 31470792 Agreement of Amyloid PET and CSF Biomarkers for Alzheimer's Disease on Lumipulse Annals of Clinical and Translational Neurology. 09, 2019 | Pubmed ID: 31464088 Exosome Release and Cargo in Down Syndrome Developmental Neurobiology. 07, 2019 | Pubmed ID: 31347291 A Nonsynonymous Mutation in PLCG2 Reduces the Risk of Alzheimer's Disease, Dementia with Lewy Bodies and Frontotemporal Dementia, and Increases the Likelihood of Longevity Acta Neuropathologica. 08, 2019 | Pubmed ID: 31131421 Nanoscale Structure of Amyloid-β Plaques in Alzheimer's Disease Scientific Reports. 03, 2019 | Pubmed ID: 30914681 Cortical Microstructure in the Behavioural Variant of Frontotemporal Dementia: Looking Beyond Atrophy Brain : a Journal of Neurology. 04, 2019 | Pubmed ID: 30906945 Perspectives on Ethnic and Racial Disparities in Alzheimer's Disease and Related Dementias: Update and Areas of Immediate Need Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 02, 2019 | Pubmed ID: 30555031 Elevated YKL-40 and Low SAPPβ:YKL-40 Ratio in Antemortem Cerebrospinal Fluid of Patients with Pathologically Confirmed FTLD Journal of Neurology, Neurosurgery, and Psychiatry. 02, 2019 | Pubmed ID: 30297518 Prevalence of Sleep Disorders in Adults With Down Syndrome: A Comparative Study of Self-Reported, Actigraphic, and Polysomnographic Findings Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine. 10, 2018 | Pubmed ID: 30353801 CSF SAPPβ, YKL-40, and NfL Along the ALS-FTD Spectrum Neurology. 10, 2018 | Pubmed ID: 30291183 Decreased CX3CL1 Levels in the Cerebrospinal Fluid of Patients With Alzheimer's Disease Frontiers in Neuroscience. 2018 | Pubmed ID: 30245615 Challenges Associated with Biomarker-based Classification Systems for Alzheimer's Disease Alzheimer's & Dementia (Amsterdam, Netherlands). 2018 | Pubmed ID: 30175226 Plasma and CSF Biomarkers for the Diagnosis of Alzheimer's Disease in Adults with Down Syndrome: a Cross-sectional Study The Lancet. Neurology. 10, 2018 | Pubmed ID: 30172624 Monoaminergic Impairment in Down Syndrome with Alzheimer's Disease Compared to Early-onset Alzheimer's Disease Alzheimer's & Dementia (Amsterdam, Netherlands). 2018 | Pubmed ID: 29780859 The Behavioral and Psychological Symptoms of Dementia in Down Syndrome (BPSD-DS) Scale: Comprehensive Assessment of Psychopathology in Down Syndrome Journal of Alzheimer's Disease : JAD. 2018 | Pubmed ID: 29689719 The Nonlinear Relationship Between Cerebrospinal Fluid Aβ42 and Tau in Preclinical Alzheimer's Disease PloS One. 2018 | Pubmed ID: 29415068 Cerebral Changes and Disrupted Gray Matter Cortical Networks in Asymptomatic Older Adults at Risk for Alzheimer's Disease Neurobiology of Aging. 04, 2018 | Pubmed ID: 29331877 Cortical Microstructural Changes Along the Alzheimer's Disease Continuum Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 03, 2018 | Pubmed ID: 29080407 Analysis of Known Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Genes Reveals a Substantial Genetic Burden in Patients Manifesting Both Diseases Not Carrying the Expansion Mutation Journal of Neurology, Neurosurgery, and Psychiatry. 02, 2018 | Pubmed ID: 28889094 Weight Loss in the Healthy Elderly Might Be a Non-cognitive Sign of Preclinical Alzheimer's Disease Oncotarget. Dec, 2017 | Pubmed ID: 29285207 Synaptic Phosphorylated α-synuclein in Dementia with Lewy Bodies Brain : a Journal of Neurology. Dec, 2017 | Pubmed ID: 29177427 The Pitfalls of Biomarker-based Classification Schemes Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 09, 2017 | Pubmed ID: 28704640 YKL-40 (Chitinase 3-like I) is Expressed in a Subset of Astrocytes in Alzheimer's Disease and Other Tauopathies Journal of Neuroinflammation. 06, 2017 | Pubmed ID: 28599675 CSF SAPPβ, YKL-40, and Neurofilament Light in Frontotemporal Lobar Degeneration Neurology. Jul, 2017 | Pubmed ID: 28592456 Diagnostic and Prognostic Value Of the Combination of Two Measures Of Verbal Memory in Mild Cognitive Impairment Due to Alzheimer's Disease Journal of Alzheimer's Disease : JAD. 2017 | Pubmed ID: 28527215 Cerebral Amyloid Angiopathy in Down Syndrome and Sporadic and Autosomal-dominant Alzheimer's Disease Alzheimer's & Dementia : the Journal of the Alzheimer's Association. Nov, 2017 | Pubmed ID: 28463681 Deleterious ABCA7 Mutations and Transcript Rescue Mechanisms in Early Onset Alzheimer's Disease Acta Neuropathologica. Sep, 2017 | Pubmed ID: 28447221 Cerebrospinal Fluid Biomarkers for Alzheimer's Disease in Down Syndrome Alzheimer's & Dementia (Amsterdam, Netherlands). 2017 | Pubmed ID: 28413821 Cerebrospinal Fluid Clearance in Alzheimer Disease Measured with Dynamic PET Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Sep, 2017 | Pubmed ID: 28302766 Cerebrospinal Fluid Mitochondrial DNA in the Alzheimer's Disease Continuum Neurobiology of Aging. 05, 2017 | Pubmed ID: 28089353 A Common Variant in the MC1R Gene (p.V92M) is Associated with Alzheimer's Disease Risk Journal of Alzheimer's Disease : JAD. 2017 | Pubmed ID: 28059796 Feasibility of Lumbar Puncture in the Study of Cerebrospinal Fluid Biomarkers for Alzheimer's Disease in Subjects with Down Syndrome Journal of Alzheimer's Disease : JAD. 2017 | Pubmed ID: 27858714 CSF MicroRNA Profiling in Alzheimer's Disease: a Screening and Validation Study Molecular Neurobiology. 11, 2017 | Pubmed ID: 27738874 Longitudinal Brain Structural Changes in Preclinical Alzheimer's Disease Alzheimer's & Dementia : the Journal of the Alzheimer's Association. May, 2017 | Pubmed ID: 27693189 Prevention of Dementia, an Immediate Challenge Revista Clinica Espanola. Dec, 2016 | Pubmed ID: 27908380 Periodontal Disease's Contribution to Alzheimer's Disease Progression In Down Syndrome Alzheimer's & Dementia (Amsterdam, Netherlands). 2016 | Pubmed ID: 27239536 Progranulin Protein Levels in Cerebrospinal Fluid in Primary Neurodegenerative Dementias Journal of Alzheimer's Disease : JAD. 2016 | Pubmed ID: 26682689 Assessing the Role of TUBA4A Gene in Frontotemporal Degeneration Neurobiology of Aging. Feb, 2016 | Pubmed ID: 26675813 Cerebrospinal Fluid Anti-Amyloid-β Autoantibodies and Amyloid PET in Cerebral Amyloid Angiopathy-Related Inflammation Journal of Alzheimer's Disease : JAD. 2016 | Pubmed ID: 26639966 Patterns of Performance on the Modified Cued Recall Test in Spanish Adults With Down Syndrome With and Without Dementia American Journal on Intellectual and Developmental Disabilities. Nov, 2015 | Pubmed ID: 26505869 Greater Specificity for Cerebrospinal Fluid P-tau231 over P-tau181 in the Differentiation of Healthy Controls from Alzheimer's Disease Journal of Alzheimer's Disease : JAD. 2015 | Pubmed ID: 26444757 Behavioural and Psychological Symptoms of Dementia in Down Syndrome: Early Indicators of Clinical Alzheimer's Disease? Cortex; a Journal Devoted to the Study of the Nervous System and Behavior. Dec, 2015 | Pubmed ID: 26343344 Amyloid Precursor Protein Metabolism and Inflammation Markers in Preclinical Alzheimer Disease Neurology. Aug, 2015 | Pubmed ID: 26180139 Analysis of the CHCHD10 Gene in Patients with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis from Spain Brain : a Journal of Neurology. Dec, 2015 | Pubmed ID: 26152333 Prevalence of Amyloid PET Positivity in Dementia Syndromes: a Meta-analysis JAMA. May, 2015 | Pubmed ID: 25988463 Relationship Between Cortical Thickness and Cerebrospinal Fluid YKL-40 in Predementia Stages of Alzheimer's Disease Neurobiology of Aging. Jun, 2015 | Pubmed ID: 25865441 Genetic Variability in SQSTM1 and Risk of Early-onset Alzheimer Dementia: a European Early-onset Dementia Consortium Study Neurobiology of Aging. May, 2015 | Pubmed ID: 25796131 Cerebral Amyloid Angiopathy-related Atraumatic Convexal Subarachnoid Hemorrhage: an ARIA Before the Tsunami Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. May, 2015 | Pubmed ID: 25735919 Early Cerebellar Hypometabolism in Patients With Frontotemporal Dementia Carrying the C9orf72 Expansion Alzheimer Disease and Associated Disorders. Oct-Dec, 2015 | Pubmed ID: 25203513 Investigation of the Role of Rare TREM2 Variants in Frontotemporal Dementia Subtypes Neurobiology of Aging. Nov, 2014 | Pubmed ID: 25042114 TREM2 Mutations Implicated in Neurodegeneration Impair Cell Surface Transport and Phagocytosis Science Translational Medicine. Jul, 2014 | Pubmed ID: 24990881 Relationship Between β-Secretase, Inflammation and Core Cerebrospinal Fluid Biomarkers for Alzheimer's Disease Journal of Alzheimer's Disease : JAD. 2014 | Pubmed ID: 24820015 Posttranslational Nitro-glycative Modifications of Albumin in Alzheimer's Disease: Implications in Cytotoxicity and Amyloid-β Peptide Aggregation Journal of Alzheimer's Disease : JAD. 2014 | Pubmed ID: 24503620 Plasma Phosphorylated TDP-43 Levels Are Elevated in Patients with Frontotemporal Dementia Carrying a C9orf72 Repeat Expansion or a GRN Mutation Journal of Neurology, Neurosurgery, and Psychiatry. Jun, 2014 | Pubmed ID: 24309270 Feasibility of Lumbar Puncture in the Study of Cerebrospinal Fluid Biomarkers for Alzheimer's Disease: a Multicenter Study in Spain Journal of Alzheimer's Disease : JAD. 2014 | Pubmed ID: 24254700 Characterization of the Repeat Expansion Size in C9orf72 in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Human Molecular Genetics. Feb, 2014 | Pubmed ID: 24057670 Rare Variants in Calcium Homeostasis Modulator 1 (CALHM1) Found in Early Onset Alzheimer's Disease Patients Alter Calcium Homeostasis PloS One. 2013 | Pubmed ID: 24069280 Expansion Mutation in C9ORF72 Does Not Influence Plasma Progranulin Levels in Frontotemporal Dementia Neurobiology of Aging. Aug, 2012 | Pubmed ID: 22502998 Enrichment of Astrocyte-Derived Extracellular Vesicles from Human Plasma Natalia Valle-Tamayo1,2, Rocío Pérez-González2,3, Gemma Chiva-Blanch4,5, Olivia Belbin1,2, Sara Serrano-Requena1,2, Sònia Sirisi1,2, Alba Cervantes González1,2, Oriol Giró4,5, Érika Sánchez-Aced1,2, Oriol Dols-Icardo1,2, Daniel Alcolea1,2, María Carmona-Iragui1,2, Amanda Jimenez4,5, Alberto Lleó1,2, Juan Fortea1,2, M. Florencia Iulita1,2 1Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autònoma de Barcelona, 2Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), 3Movement Disorders Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, 4Department of Endocrinology and Nutrition, Hospital Clínic de Barcelona, August Pi i Sunyer Biomedical Research Institute - IDIBAPS, 5Spanish Biomedical Research Network in Physiopathology of Obesity and Nutrition (CIBEROBN) JoVE 64107 Neuroscience
Enrichment of Astrocyte-Derived Extracellular Vesicles from Human Plasma Natalia Valle-Tamayo1,2, Rocío Pérez-González2,3, Gemma Chiva-Blanch4,5, Olivia Belbin1,2, Sara Serrano-Requena1,2, Sònia Sirisi1,2, Alba Cervantes González1,2, Oriol Giró4,5, Érika Sánchez-Aced1,2, Oriol Dols-Icardo1,2, Daniel Alcolea1,2, María Carmona-Iragui1,2, Amanda Jimenez4,5, Alberto Lleó1,2, Juan Fortea1,2, M. Florencia Iulita1,2 1Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autònoma de Barcelona, 2Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), 3Movement Disorders Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, 4Department of Endocrinology and Nutrition, Hospital Clínic de Barcelona, August Pi i Sunyer Biomedical Research Institute - IDIBAPS, 5Spanish Biomedical Research Network in Physiopathology of Obesity and Nutrition (CIBEROBN) JoVE 64107 Neuroscience