Manfred S. Weiss Macromolecular Crystallographyy Helmholtz-Zentrum Berlin Biography Publications Institution JoVE Articles Manfred S. Weiss has not added a biography. If you are Manfred S. Weiss and would like to personalize this page please email our Author Liaison for assistance. Publications DYW Domain Structures Imply an Unusual Regulation Principle in Plant Organellar RNA Editing Catalysis Nature Catalysis. Jun, 2021 | Pubmed ID: 34712911 Unique Features of the Bifunctional GH30 from Thermothelomyces Thermophila Revealed by Structural and Mutational Studies Carbohydrate Polymers. Dec, 2021 | Pubmed ID: 34560965 Enhanced Properties of a Benzimidazole Benzylpyrazole Lysine Demethylase Inhibitor: Mechanism-of-Action, Binding Site Analysis, and Activity in Cellular Models of Prostate Cancer Journal of Medicinal Chemistry. Oct, 2021 | Pubmed ID: 34555281 Frag4Lead: Growing Crystallographic Fragment Hits by Catalog Using Fragment-guided Template Docking Acta Crystallographica. Section D, Structural Biology. Sep, 2021 | Pubmed ID: 34473087 Substrate Binding Modes of Purine and Pyrimidine Nucleotides to Human Ecto-5'-nucleotidase (CD73) and Inhibition by Their Bisphosphonic Acid Derivatives Purinergic Signalling. Aug, 2021 | Pubmed ID: 34403084 FragMAXapp: Crystallographic Fragment-screening Data-analysis and Project-management System Acta Crystallographica. Section D, Structural Biology. Jun, 2021 | Pubmed ID: 34076593 Structural Analysis of New Compound Heterozygous Variants in PEPD Gene Identified in a Patient with Prolidase Deficiency Diagnosed by Exome Sequencing Genetics and Molecular Biology. 2021 | Pubmed ID: 33877262 Facilitated Crystal Handling Using a Simple Device for Evaporation Reduction in Microtiter Plates Journal of Applied Crystallography. Feb, 2021 | Pubmed ID: 33833659 X-ray Screening Identifies Active Site and Allosteric Inhibitors of SARS-CoV-2 Main Protease Science (New York, N.Y.). 05, 2021 | Pubmed ID: 33811162 Engineering Micromechanics of Soft Porous Crystals for Negative Gas Adsorption Chemical Science. Aug, 2020 | Pubmed ID: 34094213 The Hypothetical Periplasmic Protein PA1624 from Pseudomonas Aeruginosa Folds into a Unique Two-domain Structure Acta Crystallographica. Section F, Structural Biology Communications. Dec, 2020 | Pubmed ID: 33263573 Insulin Polymorphism Induced by Two Polyphenols: New Crystal Forms and Advances in Macromolecular Powder Diffraction Acta Crystallographica. Section D, Structural Biology. Nov, 2020 | Pubmed ID: 33135678 Prolidase - A Protein with Many Faces Biochimie. Oct, 2020 | Pubmed ID: 33045291 The Susceptibility of Disulfide Bonds Towards Radiation Damage May Be Explained by S⋯O Interactions IUCrJ. Sep, 2020 | Pubmed ID: 32939274 Co-expression with Chaperones Can Affect Protein 3D Structure As Exemplified by Loss-of-function Variants of Human Prolidase FEBS Letters. Sep, 2020 | Pubmed ID: 32598484 F2X-Universal and F2X-Entry: Structurally Diverse Compound Libraries for Crystallographic Fragment Screening Structure (London, England : 1993). 06, 2020 | Pubmed ID: 32413289 Regioselectivity of Hyoscyamine 6β-hydroxylase-catalysed Hydroxylation As Revealed by High-resolution Structural Information and QM/MM Calculations Dalton Transactions (Cambridge, England : 2003). Apr, 2020 | Pubmed ID: 32182320 In Situ Imine-Based Linker Formation for the Synthesis of Zirconium MOFs: A Route to CO Capture Materials and Ethylene Oligomerization Catalysts Inorganic Chemistry. Jan, 2020 | Pubmed ID: 31820946 Structure-Based Screening of Tetrazolylhydrazide Inhibitors Versus KDM4 Histone Demethylases ChemMedChem. 11, 2019 | Pubmed ID: 31475772 Underlying Molecular Alterations in Human Dihydrolipoamide Dehydrogenase Deficiency Revealed by Structural Analyses of Disease-causing Enzyme Variants Human Molecular Genetics. 10, 2019 | Pubmed ID: 31334547 Findable Accessible Interoperable Re-usable (FAIR) Diffraction Data Are Coming to Protein Crystallography Journal of Applied Crystallography. Jun, 2019 | Pubmed ID: 31236090 Findable Accessible Interoperable Re-usable (FAIR) Diffraction Data Are Coming to Protein Crystallography IUCrJ. May, 2019 | Pubmed ID: 31098014 Findable Accessible Interoperable Re-usable (FAIR) Diffraction Data Are Coming to Protein Crystallography Acta Crystallographica. Section D, Structural Biology. May, 2019 | Pubmed ID: 31063147 Findable Accessible Interoperable Re-usable (FAIR) Diffraction Data Are Coming to Protein Crystallography Acta Crystallographica. Section F, Structural Biology Communications. May, 2019 | Pubmed ID: 31045560 Structure of the Plastic-degrading Ideonella Sakaiensis MHETase Bound to a Substrate Nature Communications. 04, 2019 | Pubmed ID: 30979881 MXCuBE2: the Dawn of MXCuBE Collaboration Journal of Synchrotron Radiation. Mar, 2019 | Pubmed ID: 30855248 Elucidating the Formation and Transformation Mechanisms of the Switchable Metal-Organic Framework ELM-11 by Powder and Single-Crystal EPR Study Inorganic Chemistry. Oct, 2018 | Pubmed ID: 30207461 Structural Basis for Prolidase Deficiency Disease Mechanisms The FEBS Journal. 09, 2018 | Pubmed ID: 30066404 Crystal Structures of the Disease-causing D444V Mutant and the Relevant Wild Type Human Dihydrolipoamide Dehydrogenase Free Radical Biology & Medicine. 08, 2018 | Pubmed ID: 29908278 Substrate Specificity and Reaction Mechanism of Human Prolidase The FEBS Journal. 09, 2017 | Pubmed ID: 28677335 Long-Wavelength X-Ray Diffraction and Its Applications in Macromolecular Crystallography Methods in Molecular Biology (Clifton, N.J.). 2017 | Pubmed ID: 28573583 Active Site Mapping of an Aspartic Protease by Multiple Fragment Crystal Structures: Versatile Warheads To Address a Catalytic Dyad Journal of Medicinal Chemistry. 11, 2016 | Pubmed ID: 27726357 A Critical Examination of the Recently Reported Crystal Structures of the Human SMN Protein Human Molecular Genetics. 08, 2016 | Pubmed ID: 27577872 Experimental Active-Site Mapping by Fragments: Hot Spots Remote from the Catalytic Center of Endothiapepsin Journal of Medicinal Chemistry. 08, 2016 | Pubmed ID: 27463859 High-Throughput Crystallography: Reliable and Efficient Identification of Fragment Hits Structure (London, England : 1993). 08, 2016 | Pubmed ID: 27452405 Structure-based Epitope Mapping of Mycobacterium Tuberculosis Secretary Antigen MTC28 The Journal of Biological Chemistry. Jul, 2016 | Pubmed ID: 27189947 Structures of Endothiapepsin-fragment Complexes from Crystallographic Fragment Screening Using a Novel, Diverse and Affordable 96-compound Fragment Library Acta Crystallographica. Section F, Structural Biology Communications. 05, 2016 | Pubmed ID: 27139825 Six Biophysical Screening Methods Miss a Large Proportion of Crystallographically Discovered Fragment Hits: A Case Study ACS Chemical Biology. 06, 2016 | Pubmed ID: 27028906 Dual Role of the Active Site Residues of Thermus Thermophilus 3-Isopropylmalate Dehydrogenase: Chemical Catalysis and Domain Closure Biochemistry. Jan, 2016 | Pubmed ID: 26731489 Combining Dehydration, Construct Optimization and Improved Data Collection to Solve the Crystal Structure of a CRM1-RanGTP-SPN1-Nup214 Quaternary Nuclear Export Complex Acta Crystallographica. Section F, Structural Biology Communications. Dec, 2015 | Pubmed ID: 26625290 Native SAD is Maturing IUCrJ. Jul, 2015 | Pubmed ID: 26175902 Macromolecular Crystallography and What It Can Contribute to Antiparasite Drug Discovery Acta Crystallographica. Section F, Structural Biology Communications. May, 2015 | Pubmed ID: 25945700 Against the Odds? De Novo Structure Determination of a Pilin with Two Cysteine Residues by Sulfur SAD Acta Crystallographica. Section D, Biological Crystallography. May, 2015 | Pubmed ID: 25945575 Glutamate 270 Plays an Essential Role in K(+)-activation and Domain Closure of Thermus Thermophilus Isopropylmalate Dehydrogenase FEBS Letters. Jan, 2015 | Pubmed ID: 25497013 The Times They Are A-changin' - News from Acta Crystallographica Section F Acta Crystallographica. Section F, Structural Biology Communications. Dec, 2014 | Pubmed ID: 25484202 Protein Crystalline Frameworks with Controllable Interpenetration Directed by Dual Supramolecular Interactions Nature Communications. Aug, 2014 | Pubmed ID: 25144207 Structural Sampling of Glycan Interaction Profiles Reveals Mucosal Receptors for Fimbrial Adhesins of Enterotoxigenic Escherichia Coli Biology. Jul, 2013 | Pubmed ID: 24833052 Big Changes Are Ahead--a New Format for Crystallization Communications in Acta Cryst. F Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. Dec, 2013 | Pubmed ID: 24316820 Cloning, Expression, Purification, Crystallization and Preliminary X-ray Diffraction Analysis of AHP2, a Signal Transmitter Protein from Arabidopsis Thaliana Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. Feb, 2013 | Pubmed ID: 23385758 Structure Determination by Multiple-wavelength Anomalous Dispersion (MAD) at the Pr LIII Edge Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. Aug, 2012 | Pubmed ID: 22869138 Facilities for Macromolecular Crystallography at The Helmholtz-Zentrum Berlin Journal of Synchrotron Radiation. May, 2012 | Pubmed ID: 22514183 Review Panel for Acta Crystallographica Section F Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. Nov, 2011 | Pubmed ID: 22102222 Publishing Structural Genomics Results Continued: the SSGCID Special Issue Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. Oct, 2011 | Pubmed ID: 22102017 Crystallization and Preliminary X-ray Diffraction Analysis of the Wild-type Haloalkane Dehalogenase DhaA and Its Variant DhaA13 Complexed with Different Ligands Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. Feb, 2011 | Pubmed ID: 21301099 Citations in Supplementary Material Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. Dec, 2010 | Pubmed ID: 21139193 iNEXT-Discovery and Instruct-ERIC: Integrating High-End Services for Translational Research in Structural Biology Hans Wienk1, Lucia Banci2, Susan Daenke3, Eva Pereiro4, Harald Schwalbe5, David Ian Stuart6, Manfred S. Weiss7, Anastassis Perrakis1 1Division of Biochemistry and Oncode Institute, The Netherlands Cancer Institute, Amsterdam, 2CERM/CIRMMP, University of Florence, 3Instruct-ERIC, Oxford University, 4MISTRAL beamline, Alba Light Source, 5Center for Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt, 6Division of Structural Biology, Oxford University, 7Macromolecular Crystallographyy, Helmholtz-Zentrum Berlin JoVE 63435 Editorial
iNEXT-Discovery and Instruct-ERIC: Integrating High-End Services for Translational Research in Structural Biology Hans Wienk1, Lucia Banci2, Susan Daenke3, Eva Pereiro4, Harald Schwalbe5, David Ian Stuart6, Manfred S. Weiss7, Anastassis Perrakis1 1Division of Biochemistry and Oncode Institute, The Netherlands Cancer Institute, Amsterdam, 2CERM/CIRMMP, University of Florence, 3Instruct-ERIC, Oxford University, 4MISTRAL beamline, Alba Light Source, 5Center for Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt, 6Division of Structural Biology, Oxford University, 7Macromolecular Crystallographyy, Helmholtz-Zentrum Berlin JoVE 63435 Editorial
