Marc K. Hellerstein University of California at Berkeley Biography Publications Institution JoVE Articles Marc K. Hellerstein has not added a biography. If you are Marc K. Hellerstein and would like to personalize this page please email our Author Liaison for assistance. Publications 24-hydroxycholesterol Replacement Rate Measured in Blood is a Non-invasive Biomarker of Brain Demyelination and Remyelination in Cuprizone-treated Mice Experimental Neurology. Jun, 2023 | Pubmed ID: 37003487 Acetyl-CoA Carboxylase Inhibitor Increases LDL-apoB Production Rate in NASH with Cirrhosis: Prevention by Fenofibrate Journal of Lipid Research. Mar, 2023 | Pubmed ID: 36737040 Elevated De Novo Lipogenesis, Slow Liver Triglyceride Turnover, and Clinical Correlations in Nonalcoholic Steatohepatitis Patients Journal of Lipid Research. Sep, 2022 | Pubmed ID: 35835205 Exercise Reduced the Formation of New Adipocytes in the Adipose Tissue of Mice in Vivo PloS One. 2021 | Pubmed ID: 33471817 Adipose Depot-specific Effects of 16 weeks of Pioglitazone on in Vivo Adipogenesis in Women with Obesity: a Randomised Controlled Trial Diabetologia. Jan, 2021 | Pubmed ID: 33001232 De Novo Lipogenesis is Essential for Platelet Production in Humans Nature Metabolism. 10, 2020 | Pubmed ID: 32929234 Surprising Findings in a 'well-understood' Nutrient-assimilation Pathway Nature Metabolism. Jul, 2020 | Pubmed ID: 32694796 Insulin Resistance Drives Hepatic De Novo Lipogenesis in Nonalcoholic Fatty Liver Disease The Journal of Clinical Investigation. Mar, 2020 | Pubmed ID: 31805015 Measurement of Leukemic B-Cell Growth Kinetics in Patients with Chronic Lymphocytic Leukemia Methods in Molecular Biology (Clifton, N.J.). 2019 | Pubmed ID: 30350203 Racial Differences in in Vivo Adipose Lipid Kinetics in Humans Journal of Lipid Research. Sep, 2018 | Pubmed ID: 29910190 Association of In Vivo Adipose Tissue Cellular Kinetics With Markers of Metabolic Health in Humans The Journal of Clinical Endocrinology and Metabolism. Jul, 2017 | Pubmed ID: 28323935 A Critical Role for ChREBP-mediated FGF21 Secretion in Hepatic Fructose Metabolism Molecular Metabolism. Jan, 2017 | Pubmed ID: 28123933 Identifying Nonalcoholic Fatty Liver Disease Patients with Active Fibrosis by Measuring Extracellular Matrix Remodeling Rates in Tissue and Blood Hepatology (Baltimore, Md.). Jan, 2017 | Pubmed ID: 27706836 Proteome-wide Muscle Protein Fractional Synthesis Rates Predict Muscle Mass Gain in Response to a Selective Androgen Receptor Modulator in Rats American Journal of Physiology. Endocrinology and Metabolism. Mar, 2016 | Pubmed ID: 26714847 Reduced In vivo Hepatic Proteome Replacement Rates but Not Cell Proliferation Rates Predict Maximum Lifespan Extension in Mice Aging Cell. Feb, 2016 | Pubmed ID: 26541492 In Vivo 2H2O Administration Reveals Impaired Triglyceride Storage in Adipose Tissue of Insulin-resistant Humans Journal of Lipid Research. Feb, 2015 | Pubmed ID: 25418322 Treatment of Diabetic Rats with Insulin or a Synthetic Insulin Receptor Agonist Peptide Leads to Divergent Metabolic Responses Diabetes. Mar, 2015 | Pubmed ID: 25315006 Human Regulatory T Cells Against Minor Histocompatibility Antigens: Ex Vivo Expansion for Prevention of Graft-versus-host Disease Blood. Sep, 2013 | Pubmed ID: 23908471 Longitudinal Changes in Total Body Creatine Pool Size and Skeletal Muscle Mass Using the D-creatine Dilution Method Journal of Cachexia, Sarcopenia and Muscle. Jun, 2013 | Pubmed ID: 23797207 A Pilot Study Demonstrating a Non-invasive Method for the Measurement of Protein Turnover in Skin Disorders: Application to Psoriasis Clinical and Translational Medicine. Jun, 2013 | Pubmed ID: 23773261 The Effect of Long Term Calorie Restriction on in Vivo Hepatic Proteostatis: a Novel Combination of Dynamic and Quantitative Proteomics Molecular & Cellular Proteomics : MCP. Dec, 2012 | Pubmed ID: 22984287 Cerebrospinal Fluid-based Kinetic Biomarkers of Axonal Transport in Monitoring Neurodegeneration The Journal of Clinical Investigation. Sep, 2012 | Pubmed ID: 22922254 The Effects of Physiological Adaptations to Calorie Restriction on Global Cell Proliferation Rates American Journal of Physiology. Endocrinology and Metabolism. Apr, 2011 | Pubmed ID: 21285400 Calorie Restriction Increases Fatty Acid Synthesis and Whole Body Fat Oxidation Rates American Journal of Physiology. Endocrinology and Metabolism. Jan, 2010 | Pubmed ID: 19887594 Isolation of Malignant B Cells from Patients with Chronic Lymphocytic Leukemia (CLL) for Analysis of Cell Proliferation: Validation of a Simplified Method Suitable for Multi-center Clinical Studies Leukemia Research. Jun, 2010 | Pubmed ID: 19854509 Improvements in Body Fat Distribution and Circulating Adiponectin by Alternate-day Fasting Versus Calorie Restriction The Journal of Nutritional Biochemistry. Mar, 2010 | Pubmed ID: 19195863 Alternate-day Fasting Reduces Global Cell Proliferation Rates Independently of Dietary Fat Content in Mice Nutrition (Burbank, Los Angeles County, Calif.). Apr, 2009 | Pubmed ID: 19084375 Central Memory CD8+ T Cells Appear to Have a Shorter Lifespan and Reduced Abundance As a Function of HIV Disease Progression Journal of Immunology (Baltimore, Md. : 1950). Jun, 2008 | Pubmed ID: 18523254 Do Calorie Restriction or Alternate-day Fasting Regimens Modulate Adipose Tissue Physiology in a Way That Reduces Chronic Disease Risk? Nutrition Reviews. Jun, 2008 | Pubmed ID: 18522622 A Gene Expression Network Model of Type 2 Diabetes Links Cell Cycle Regulation in Islets with Diabetes Susceptibility Genome Research. May, 2008 | Pubmed ID: 18347327 A Critique of the Molecular Target-based Drug Discovery Paradigm Based on Principles of Metabolic Control: Advantages of Pathway-based Discovery Metabolic Engineering. Jan, 2008 | Pubmed ID: 17962055 Alternate-day Fasting and Chronic Disease Prevention: a Review of Human and Animal Trials The American Journal of Clinical Nutrition. Jul, 2007 | Pubmed ID: 17616757 Pharmacological Doses of Dietary Curcumin Increase Colon Epithelial Cell Proliferation in Vivo in Rats Phytotherapy Research : PTR. Oct, 2007 | Pubmed ID: 17582595 Dose Effects of Modified Alternate-day Fasting Regimens on in Vivo Cell Proliferation and Plasma Insulin-like Growth Factor-1 in Mice Journal of Applied Physiology (Bethesda, Md. : 1985). Aug, 2007 | Pubmed ID: 17495119 Delayed Secretory Pathway Contributions to VLDL-triglycerides from Plasma NEFA, Diet, and De Novo Lipogenesis in Humans Journal of Lipid Research. Nov, 2006 | Pubmed ID: 16929033 In Vivo Measurement of DNA Synthesis Rates of Colon Epithelial Cells in Carcinogenesis Biochemical and Biophysical Research Communications. May, 2005 | Pubmed ID: 15845379 Effect of Nucleoside Reverse Transcriptase Inhibitors on Mitochondrial DNA Synthesis in Rats and Humans Journal of Acquired Immune Deficiency Syndromes (1999). Sep, 2004 | Pubmed ID: 15319672 Stable Isotope-mass Spectrometric Measurements of Molecular Fluxes in Vivo: Emerging Applications in Drug Development Current Opinion in Molecular Therapeutics. Jun, 2004 | Pubmed ID: 15264427 New Stable Isotope-mass Spectrometric Techniques for Measuring Fluxes Through Intact Metabolic Pathways in Mammalian Systems: Introduction of Moving Pictures into Functional Genomics and Biochemical Phenotyping Metabolic Engineering. Jan, 2004 | Pubmed ID: 14734258 Turnover of Adipose Components and Mitochondrial DNA in Humans: Kinetic Biomarkers for Human Immunodeficiency Virus-associated Lipodystrophy and Mitochondrial Toxicity? Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. 2003 | Pubmed ID: 12942375 In Vivo Measurement of Fluxes Through Metabolic Pathways: the Missing Link in Functional Genomics and Pharmaceutical Research Annual Review of Nutrition. 2003 | Pubmed ID: 12704218 Measurement of Mitochondrial DNA Synthesis in Vivo Using a Stable Isotope-mass Spectrometric Technique Journal of Applied Physiology (Bethesda, Md. : 1985). Jun, 2003 | Pubmed ID: 12562673 Carbohydrate-induced Hypertriglyceridemia: Modifying Factors and Implications for Cardiovascular Risk Current Opinion in Lipidology. Feb, 2002 | Pubmed ID: 11790961 Increased Turnover of T Lymphocytes in HIV-1 Infection and Its Reduction by Antiretroviral Therapy The Journal of Experimental Medicine. Nov, 2001 | Pubmed ID: 11696593 Measurement of Cell Proliferation by Labeling of DNA with Stable Isotope-labeled Glucose: Studies in Vitro, in Animals, and in Humans Proceedings of the National Academy of Sciences of the United States of America. Jan, 1998 | Pubmed ID: 9435257 Measuring In Vivo Adipose Tissue Kinetics in Humans Using the Deuterium (2H)-Labeling Approach Dereck Kibodeaux1, Jonathan Savoie1, Eric Ravussin1, Mark Fitch2, Marc K. Hellerstein2, Ursula White1 1Pennington Biomedical Research Center, Louisiana State University System, 2University of California at Berkeley JoVE 64883 Biology
Measuring In Vivo Adipose Tissue Kinetics in Humans Using the Deuterium (2H)-Labeling Approach Dereck Kibodeaux1, Jonathan Savoie1, Eric Ravussin1, Mark Fitch2, Marc K. Hellerstein2, Ursula White1 1Pennington Biomedical Research Center, Louisiana State University System, 2University of California at Berkeley JoVE 64883 Biology
