Nichole R. Klatt

Department of Pharmaceutics, Washington National Primate Research Center, University of Washington

Affiliated withWashington National Primate Research Center, University of Washington

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 16	2017

Other Publications

Article	Year
Severe depletion of mucosal CD4+ T cells in AIDS-free simian immunodeficiency virus-infected sooty mangabeys. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17709517	2007
Short-lived infected cells support virus replication in sooty mangabeys naturally infected with simian immunodeficiency virus: implications for AIDS pathogenesis. Journal of virology\| PubMed ID: 18216113	2008
CD127 and CD25 expression defines CD4+ T cell subsets that are differentially depleted during HIV infection. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18390743	2008
Availability of activated CD4+ T cells dictates the level of viremia in naturally SIV-infected sooty mangabeys. The Journal of clinical investigation\| PubMed ID: 18497876	2008
Bone marrow-based homeostatic proliferation of mature T cells in nonhuman primates: implications for AIDS pathogenesis. Blood\| PubMed ID: 18832134	2009
CD4 downregulation by memory CD4+ T cells in vivo renders African green monkeys resistant to progressive SIVagm infection. Nature medicine\| PubMed ID: 19525963	2009
Vaccine-induced, simian immunodeficiency virus-specific CD8+ T cells reduce virus replication but do not protect from simian immunodeficiency virus disease progression. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19542473	2009
Global genomic analysis reveals rapid control of a robust innate response in SIV-infected sooty mangabeys. The Journal of clinical investigation\| PubMed ID: 19959874	2009
CD8+ lymphocytes control viral replication in SIVmac239-infected rhesus macaques without decreasing the lifespan of productively infected cells. PLoS pathogens\| PubMed ID: 20126441	2010
Lineage-specific T-cell reconstitution following in vivo CD4+ and CD8+ lymphocyte depletion in nonhuman primates. Blood\| PubMed ID: 20484087	2010
Downregulation of robust acute type I interferon responses distinguishes nonpathogenic simian immunodeficiency virus (SIV) infection of natural hosts from pathogenic SIV infection of rhesus ... Journal of virology\| PubMed ID: 20484518	2010
Th17 cell dynamics in HIV infection. Current opinion in HIV and AIDS\| PubMed ID: 20543590	2010
Reconstitution of CD4 T cells in bronchoalveolar lavage fluid after initiation of highly active antiretroviral therapy. Journal of virology\| PubMed ID: 20610726	2010
Mechanisms underlying γδ T-cell subset perturbations in SIV-infected Asian rhesus macaques. Blood\| PubMed ID: 20660793	2010
Damaged intestinal epithelial integrity linked to microbial translocation in pathogenic simian immunodeficiency virus infections. PLoS pathogens\| PubMed ID: 20808901	2010
Viral CTL escape mutants are generated in lymph nodes and subsequently become fixed in plasma and rectal mucosa during acute SIV infection of macaques. PLoS pathogens\| PubMed ID: 21625590	2011
CD4-like immunological function by CD4- T cells in multiple natural hosts of simian immunodeficiency virus. Journal of virology\| PubMed ID: 21715501	2011
SIV infection of rhesus macaques results in dysfunctional T- and B-cell responses to neo and recall Leishmania major vaccination. Blood\| PubMed ID: 21960586	2011
Why don't CD8+ T cells reduce the lifespan of SIV-infected cells in vivo? PLoS computational biology\| PubMed ID: 21990968	2011
Depletion of CD4⁺ T cells abrogates post-peak decline of viremia in SIV-infected rhesus macaques. The Journal of clinical investigation\| PubMed ID: 22005304	2011
Dynamics of simian immunodeficiency virus SIVmac239 infection in pigtail macaques. Journal of virology\| PubMed ID: 22090099	2012
Nonpathogenic simian immunodeficiency virus infections. Cold Spring Harbor perspectives in medicine\| PubMed ID: 22315718	2012
CD4+ T cells and HIV: A paradoxical Pas de Deux. Science translational medicine\| PubMed ID: 22378922	2012
Microbial translocation, immune activation, and HIV disease. Trends in microbiology\| PubMed ID: 23062765	2013
Transcriptional profiling of experimental CD8(+) lymphocyte depletion in rhesus macaques infected with simian immunodeficiency virus SIVmac239. Journal of virology\| PubMed ID: 23097439	2013
Superior T memory stem cell persistence supports long-lived T cell memory. The Journal of clinical investigation\| PubMed ID: 23281401	2013
Probiotic/prebiotic supplementation of antiretrovirals improves gastrointestinal immunity in SIV-infected macaques. The Journal of clinical investigation\| PubMed ID: 23321668	2013
Rate of AIDS progression is associated with gastrointestinal dysfunction in simian immunodeficiency virus-infected pigtail macaques. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 23401593	2013
Immune activation and HIV persistence: implications for curative approaches to HIV infection. Immunological reviews\| PubMed ID: 23772629	2013
High production rates sustain in vivo levels of PD-1high simian immunodeficiency virus-specific CD8 T cells in the face of rapid clearance. Journal of virology\| PubMed ID: 23824823	2013
Residual immune dysregulation syndrome in treated HIV infection. Advances in immunology\| PubMed ID: 23886064	2013
Homeostatic cytokines induce CD4 downregulation in African green monkeys independently of antigen exposure to generate simian immunodeficiency virus-resistant CD8αα T cells. Journal of virology\| PubMed ID: 24991011	2014
HIV transmission. Selection bias at the heterosexual HIV-1 transmission bottleneck. Science (New York, N.Y.)\| PubMed ID: 25013080	2014
HIV vaccine trial exploits a dual and central role for innate immunity. Journal of virology\| PubMed ID: 25122775	2014
Limited HIV infection of central memory and stem cell memory CD4+ T cells is associated with lack of progression in viremic individuals. PLoS pathogens\| PubMed ID: 25167059	2014
Hypercytotoxicity and rapid loss of NKp44+ innate lymphoid cells during acute SIV infection. PLoS pathogens\| PubMed ID: 25503264	2014
HIV and mucosal barrier interactions: consequences for transmission and pathogenesis. Current opinion in immunology\| PubMed ID: 26151777	2015
SIV-induced Translocation of Bacterial Products in the Liver Mobilizes Myeloid Dendritic and Natural Killer Cells Associated With Liver Damage. The Journal of infectious diseases\| PubMed ID: 26238685	2016
Experimental colitis in SIV-uninfected rhesus macaques recapitulates important features of pathogenic SIV infection. Nature communications\| PubMed ID: 26282376	2015
Gut-Resident Lactobacillus Abundance Associates with IDO1 Inhibition and Th17 Dynamics in SIV-Infected Macaques. Cell reports\| PubMed ID: 26586432	2015
Microbial translocation and microbiome dysbiosis in HIV-associated immune activation. Current opinion in HIV and AIDS\| PubMed ID: 26679414	2016
Enhancement of Microbiota in Healthy Macaques Results in Beneficial Modulation of Mucosal and Systemic Immune Function. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 26826246	2016
Effects of Fecal Microbial Transplantation on Microbiome and Immunity in Simian Immunodeficiency Virus-Infected Macaques. Journal of virology\| PubMed ID: 26937040	2016
Analysis of the In Vivo Turnover of CD4+ T-Cell Subsets in Chronically SIV-Infected Sooty Mangabeys. PloS one\| PubMed ID: 27227993	2016
Microbiome Composition and Function Drives Wound-Healing Impairment in the Female Genital Tract. PLoS pathogens\| PubMed ID: 27656899	2016
Loss of immune homeostasis dictates SHIV rebound after stem-cell transplantation. JCI insight\| PubMed ID: 28239658	2017