Paul M.L. Janssen

Department of Physiology and Cell Biology, The Ohio State University

Affiliated withThe Ohio State University

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 98	2014

Other Publications

Article	Year
Potentiation of beta-adrenergic inotropic response by pyruvate in failing human myocardium. Cardiovascular research\| PubMed ID: 11744019	2002
Myofilament properties comprise the rate-limiting step for cardiac relaxation at body temperature in the rat. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 11788397	2002
Influence of pyruvate on contractile performance and Ca(2+) cycling in isolated failing human myocardium. Circulation\| PubMed ID: 11790700	2002
Hydroxyl radical-induced acute diastolic dysfunction is due to calcium overload via reverse-mode Na(+)-Ca(2+) exchange. Circulation research\| PubMed ID: 12016265	2002
Intracellular beta-blockade: overexpression of Galpha(i2) depresses the beta-adrenergic response in intact myocardium. Cardiovascular research\| PubMed ID: 12123769	2002
Physiological determinants of contractile force generation and calcium handling in mouse myocardium. Journal of molecular and cellular cardiology\| PubMed ID: 12392997	2002
Selective contractile dysfunction of left, not right, ventricular myocardium in the SHHF rat. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 12424099	2003
Frequency- and afterload-dependent cardiac modulation in vivo by troponin I with constitutively active protein kinase A phosphorylation sites. Circulation research\| PubMed ID: 14726477	2004
Abnormal frequency-dependent responses represent the pathophysiologic signature of contractile failure in human myocardium. Journal of molecular and cellular cardiology\| PubMed ID: 14734045	2004
Improved systolic and diastolic myocardial function with intracoronary pyruvate in patients with congestive heart failure. European journal of heart failure\| PubMed ID: 14984729	2004
Cardiac adenoviral S100A1 gene delivery rescues failing myocardium. The Journal of clinical investigation\| PubMed ID: 15578088	2004
Utrophin deficiency worsens cardiac contractile dysfunction present in dystrophin-deficient mdx mice. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 16024571	2005
Effect of muscle dimensions on trabecular contractile performance under physiological conditions. Pflügers Archiv : European journal of physiology\| PubMed ID: 16082545	2006
Targeted overexpression of sarcolipin in the mouse heart decreases sarcoplasmic reticulum calcium transport and cardiac contractility. The Journal of biological chemistry\| PubMed ID: 16365042	2006
Murine strain differences in contractile function are temperature- and frequency-dependent. Pflügers Archiv : European journal of physiology\| PubMed ID: 16397793	2006
Frequency-dependent contractile response of isolated cardiac trabeculae under hypo-, normo-, and hyperthermic conditions. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 16410377	2006
Measurement of myofilament calcium sensitivity at physiological temperature in intact cardiac trabeculae. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 16603708	2006
LAMP-2 deficient mice show depressed cardiac contractile function without significant changes in calcium handling. Basic research in cardiology\| PubMed ID: 16604439	2006
SERCA overexpression reduces hydroxyl radical injury in murine myocardium. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 16798816	2006
Frequency-dependent acceleration of relaxation involves decreased myofilament calcium sensitivity. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 17209002	2007
Frequency-dependent contractile strength in mice over- and underexpressing the sarco(endo)plasmic reticulum calcium-ATPase. American journal of physiology. Regulatory, integrative and comparative physiology\| PubMed ID: 17255213	2007
Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy. The Journal of clinical investigation\| PubMed ID: 17380205	2007
Influence of pyruvate on economy of contraction in isolated rabbit myocardium. European journal of heart failure\| PubMed ID: 17532261	2007
Atrial glutathione content, calcium current, and contractility. The Journal of biological chemistry\| PubMed ID: 17656369	2007
A translational approach for limb vascular delivery of the micro-dystrophin gene without high volume or high pressure for treatment of Duchenne muscular dystrophy. Journal of translational medicine\| PubMed ID: 17892583	2007
Determinants of frequency-dependent contraction and relaxation of mammalian myocardium. Journal of molecular and cellular cardiology\| PubMed ID: 17919652	2007
Induction of hypertrophy in vitro by mechanical loading in adult rabbit myocardium. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 17933962	2007
Gender comparison of contractile performance and beta-adrenergic response in isolated rat cardiac trabeculae. Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology\| PubMed ID: 18030479	2008
Dissociation of force decline from calcium decline by preload in isolated rabbit myocardium. Pflügers Archiv : European journal of physiology\| PubMed ID: 18057959	2008
Molecular basis of diastolic dysfunction. Heart failure clinics\| PubMed ID: 18313621	2008
Neuronal nitric oxide synthase signaling within cardiac myocytes targets phospholamban. American journal of physiology. Cell physiology\| PubMed ID: 18400986	2008
Claudin-5 levels are reduced in human end-stage cardiomyopathy. Journal of molecular and cellular cardiology\| PubMed ID: 18513742	2008
Truncated CASK does not alter skeletal muscle or protein interactors. Muscle & nerve\| PubMed ID: 18642383	2008
Overexpression of Galgt2 in skeletal muscle prevents injury resulting from eccentric contractions in both mdx and wild-type mice. American journal of physiology. Cell physiology\| PubMed ID: 19109526	2009
The positive force-frequency relationship is maintained in absence of sarcoplasmic reticulum function in rabbit, but not in rat myocardium. Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology\| PubMed ID: 19123061	2009
Temporal changes in expression of connexin 43 after load-induced hypertrophy in vitro. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 19136602	2009
Pulmonary artery banding alters the expression of Ca2+ transport proteins in the right atrium in rabbits. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 19376811	2009
Variability in interbeat duration influences myocardial contractility in rat cardiac trabeculae. The open cardiovascular medicine journal\| PubMed ID: 19440237	2008
A random cycle length approach for assessment of myocardial contraction in isolated rabbit myocardium. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 19749159	2009
Impairment of diastolic function by lack of frequency-dependent myofilament desensitization rabbit right ventricular hypertrophy. Circulation. Heart failure\| PubMed ID: 19808378	2009
Nitroxyl enhances myocyte Ca2+ transients by exclusively targeting SR Ca2+-cycling. Frontiers in bioscience (Elite edition)\| PubMed ID: 20036906	2010
Effects of dietary omega-3 fatty acids on ventricular function in dogs with healed myocardial infarctions: in vivo and in vitro studies. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 20097770	2010
Increased phosphorylation of tropomyosin, troponin I, and myosin light chain-2 after stretch in rabbit ventricular myocardium under physiological conditions. Journal of molecular and cellular cardiology\| PubMed ID: 20298699	2010
Follistatin gene delivery enhances muscle growth and strength in nonhuman primates. Science translational medicine\| PubMed ID: 20368179	2009
A genetic model of amyotrophic lateral sclerosis in zebrafish displays phenotypic hallmarks of motoneuron disease. Disease models & mechanisms\| PubMed ID: 20504969	2010
Kinetics of cardiac muscle contraction and relaxation are linked and determined by properties of the cardiac sarcomere. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 20656885	2010
Myocardial contraction-relaxation coupling. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 20852049	2010
Lengthening-contractions in isolated myocardium impact force development and worsen cardiac contractile function in the mdx mouse model of muscular dystrophy. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 21127205	2011
Peptide-based inhibition of NF-ÎºB rescues diaphragm muscle contractile dysfunction in a murine model of Duchenne muscular dystrophy. Molecular medicine (Cambridge, Mass.)\| PubMed ID: 21267511	2011
Challenges in cardiac muscle physiology. Frontiers in physiology\| PubMed ID: 21423345	2010
Effects of hydroxyl radical induced-injury in atrial versus ventricular myocardium of dog and rabbit. Frontiers in physiology\| PubMed ID: 21423367	2010
In vitro studies of early cardiac remodeling: impact on contraction and calcium handling. Frontiers in bioscience (Scholar edition)\| PubMed ID: 21622254	2011
Effects of increased systolic Ca²⁺ and phospholamban phosphorylation during β-adrenergic stimulation on Ca²⁺ transient kinetics in cardiac myocytes. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 21765055	2011
Early treatment with lisinopril and spironolactone preserves cardiac and skeletal muscle in Duchenne muscular dystrophy mice. Circulation\| PubMed ID: 21768542	2011
Effect of twitch interval duration on the contractile function of subsequent twitches in isolated rat, rabbit, and dog myocardium under physiological conditions. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 21778421	2011
mdx(⁵cv) mice manifest more severe muscle dysfunction and diaphragm force deficits than do mdx Mice. The American journal of pathology\| PubMed ID: 21893021	2011
Contractile strength during variable heart duration is species and preload dependent. Journal of biomedicine & biotechnology\| PubMed ID: 22131801	2011
IKKα and alternative NF-κB regulate PGC-1β to promote oxidative muscle metabolism. The Journal of cell biology\| PubMed ID: 22351927	2012
Contractile parameters and occurrence of alternans in isolated rat myocardium at supra-physiological stimulation frequency. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 22467303	2012
Effects of increased preload on the force-frequency response and contractile kinetics in early stages of cardiac muscle hypertrophy. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 22467304	2012
Sustaining cardiac claudin-5 levels prevents functional hallmarks of cardiomyopathy in a muscular dystrophy mouse model. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 22547149	2012
Staurosporine inhibits frequency-dependent myofilament desensitization in intact rabbit cardiac trabeculae. Biochemistry research international\| PubMed ID: 22649731	2012
The rates of Ca2+ dissociation and cross-bridge detachment from ventricular myofibrils as reported by a fluorescent cardiac troponin C. The Journal of biological chemistry\| PubMed ID: 22718768	2012
Homologous recombination mediates functional recovery of dysferlin deficiency following AAV5 gene transfer. PloS one\| PubMed ID: 22720081	2012
Cardiomyopathy in the dystrophin/utrophin-deficient mouse model of severe muscular dystrophy is characterized by dysregulation of matrix metalloproteinases. Neuromuscular disorders : NMD\| PubMed ID: 22749475	2012
Impact of hydroxyl radical-induced injury on calcium handling and myofilament sensitivity in isolated myocardium. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 22773772	2012
Role of endothelin in the induction of cardiac hypertrophy in vitro. PloS one\| PubMed ID: 22912821	2012
Rac-induced left ventricular dilation in thyroxin-treated ZmRacD transgenic mice: role of cardiomyocyte apoptosis and myocardial fibrosis. PloS one\| PubMed ID: 22936985	2012
Effects of increased systolic Ca(2+) and β-adrenergic stimulation on Ca(2+) transient decline in NOS1 knockout cardiac myocytes. Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society\| PubMed ID: 22960389	2012
Vascular remodeling-associated hypertension leads to left ventricular hypertrophy and contractile dysfunction in profilin-1 transgenic mice. Journal of cardiovascular pharmacology\| PubMed ID: 22967989	2012
Post-translational modifications of myofilament proteins involved in length-dependent prolongation of relaxation in rabbit right ventricular myocardium. Archives of biochemistry and biophysics\| PubMed ID: 23085150	2013
Up-regulation of sarcoplasmic reticulum Ca(2+) uptake leads to cardiac hypertrophy, contractile dysfunction and early mortality in mice deficient in CASQ2. Cardiovascular research\| PubMed ID: 23135969	2013
The force-temperature relationship in healthy and dystrophic mouse diaphragm; implications for translational study design. Frontiers in physiology\| PubMed ID: 23162469	2012
Tropomyosin Ser-283 pseudo-phosphorylation slows myofibril relaxation. Archives of biochemistry and biophysics\| PubMed ID: 23232082	2013
Effect of muscle length on cross-bridge kinetics in intact cardiac trabeculae at body temperature. The Journal of general physiology\| PubMed ID: 23277479	2013
Myocardial Rac1 exhibits partial involvement in thyroxin-induced cardiomyocyte hypertrophy and its inhibition is not sufficient to improve cardiac dysfunction or contractile abnormalities in... Journal of cardiovascular pharmacology\| PubMed ID: 23429587	2013
N-Glycolylneuraminic acid deficiency worsens cardiac and skeletal muscle pathophysiology in α-sarcoglycan-deficient mice. Glycobiology\| PubMed ID: 23514716	2013
The positive inotropic effect of pyruvate involves an increase in myofilament calcium sensitivity. PloS one\| PubMed ID: 23691074	2013
Decreased RyR2 refractoriness determines myocardial synchronization of aberrant Ca2+ release in a genetic model of arrhythmia. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23733959	2013
Micro-dystrophin and follistatin co-delivery restores muscle function in aged DMD model. Human molecular genetics\| PubMed ID: 23863459	2013
Small and large animal models in cardiac contraction research: advantages and disadvantages. Pharmacology & therapeutics\| PubMed ID: 24140081	2014
Prednisolone attenuates improvement of cardiac and skeletal contractile function and histopathology by lisinopril and spironolactone in the mdx mouse model of Duchenne muscular dystrophy. PloS one\| PubMed ID: 24551095	2014