Philip R. Taylor Systems Immunity Research Institute, Division of Infection and Immunity Cardiff University Biography Publications Institution JoVE Articles Philip R. Taylor has not added a biography. If you are Philip R. Taylor and would like to personalize this page please email our Author Liaison for assistance. Publications Th1 Cells Alter the Inflammatory Signature of IL-6 by Channeling STAT Transcription Factors to Alu-like Retroelements Journal of Immunology (Baltimore, Md. : 1950). Jul, 2023 | Pubmed ID: 37272871 Terminal Complement Pathway Activation Drives Synaptic Loss in Alzheimer's Disease Models Acta Neuropathologica Communications. Jul, 2022 | Pubmed ID: 35794654 Oxylipin Metabolism is Controlled by Mitochondrial β-oxidation During Bacterial Inflammation Nature Communications. Jan, 2022 | Pubmed ID: 35013270 A Novel Strategy to Identify Haematology Patients at High Risk of Developing Aspergillosis Frontiers in Immunology. 2021 | Pubmed ID: 34975870 Modest Changes in Spi1 Dosage Reveal the Potential for Altered Microglial Function As Seen in Alzheimer's Disease Scientific Reports. Jul, 2021 | Pubmed ID: 34294785 PIP2 Depletion and Altered Endocytosis Caused by Expression of Alzheimer's Disease-protective Variant PLCγ2 R522 The EMBO Journal. Sep, 2021 | Pubmed ID: 34254352 Single-Nucleus RNA Sequencing Identifies New Classes of Proximal Tubular Epithelial Cells in Kidney Fibrosis Journal of the American Society of Nephrology : JASN. Oct, 2021 | Pubmed ID: 34155061 A Human Dectin-2 Deficiency Associated With Invasive Aspergillosis The Journal of Infectious Diseases. Oct, 2021 | Pubmed ID: 33733279 Dependence on Mincle and Dectin-2 Varies With Multiple Species During Systemic Infection Frontiers in Microbiology. 2021 | Pubmed ID: 33717025 Dependence on Dectin-1 Varies With Multiple Species Frontiers in Microbiology. 2019 | Pubmed ID: 31447813 The Protective Effect of Inflammatory Monocytes During Systemic C. Albicans Infection is Dependent on Collaboration Between C-type Lectin-like Receptors PLoS Pathogens. Jun, 2019 | Pubmed ID: 31242262 Development and Characterization of Novel Anti-C5 Monoclonal Antibodies Capable of Inhibiting Complement in Multiple Species Immunology. Aug, 2019 | Pubmed ID: 31120547 Activation of Naïve CD4 T Cells Re-tunes STAT1 Signaling to Deliver Unique Cytokine Responses in Memory CD4 T Cells Nature Immunology. Apr, 2019 | Pubmed ID: 30890796 Structural and Functional Analyses of the Shedding Protease ADAM17 in HoxB8-Immortalized Macrophages and Dendritic-like Cells Journal of Immunology (Baltimore, Md. : 1950). Nov, 2018 | Pubmed ID: 30355783 Differential Susceptibility of Dectin-1 Isoforms to Functional Inactivation by Neutrophil and Fungal Proteases FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jun, 2018 | Pubmed ID: 29401615 Peritoneal Tissue-resident Macrophages Are Metabolically Poised to Engage Microbes Using Tissue-niche Fuels Nature Communications. Dec, 2017 | Pubmed ID: 29234000 Networks of Enzymatically Oxidized Membrane Lipids Support Calcium-dependent Coagulation Factor Binding to Maintain Hemostasis Science Signaling. Nov, 2017 | Pubmed ID: 29184033 Death Receptor 3 Regulates Distinct Pathological Attributes of Acute Versus Chronic Murine Allergic Lung Inflammation Cellular Immunology. Oct, 2017 | Pubmed ID: 28942944 MiR-21 Promotes Fibrogenesis in Peritoneal Dialysis The American Journal of Pathology. Jul, 2017 | Pubmed ID: 28495592 Myeloid 12/15-LOX Regulates B Cell Numbers and Innate Immune Antibody Levels Wellcome Open Research. Jan, 2017 | Pubmed ID: 28239665 Peritoneal Macrophage Heterogeneity is Associated with Different Peritoneal Dialysis Outcomes Kidney International. May, 2017 | Pubmed ID: 28065517 Death Receptor 3 Promotes Chemokine-Directed Leukocyte Recruitment in Acute Resolving Inflammation and Is Essential for Pathological Development of Mesothelial Fibrosis in Chronic Disease The American Journal of Pathology. Nov, 2016 | Pubmed ID: 27664471 IL-10 Differentially Controls the Infiltration of Inflammatory Macrophages and Antigen-presenting Cells During Inflammation European Journal of Immunology. Sep, 2016 | Pubmed ID: 27378515 IL-27 Induced by Select Candida Spp. Via TLR7/NOD2 Signaling and IFN-β Production Inhibits Fungal Clearance Journal of Immunology (Baltimore, Md. : 1950). Jul, 2016 | Pubmed ID: 27259855 CD200 Receptor Restriction of Myeloid Cell Responses Antagonizes Antiviral Immunity and Facilitates Cytomegalovirus Persistence Within Mucosal Tissue PLoS Pathogens. Feb, 2015 | Pubmed ID: 25654642 Understanding Local Macrophage Phenotypes in Disease: Shape-shifting Macrophages Nature Medicine. Feb, 2015 | Pubmed ID: 25654602 Interleukin-10 Regulates the Inflammasome-driven Augmentation of Inflammatory Arthritis and Joint Destruction Arthritis Research & Therapy. Aug, 2014 | Pubmed ID: 25175678 The Transcription Factor Gata6 Links Tissue Macrophage Phenotype and Proliferative Renewal Science (New York, N.Y.). May, 2014 | Pubmed ID: 24762537 Neutrophils Recruited by IL-22 in Peripheral Tissues Function As TRAIL-dependent Antiviral Effectors Against MCMV Cell Host & Microbe. Apr, 2014 | Pubmed ID: 24721575 MiR-192 Induces G2/M Growth Arrest in Aristolochic Acid Nephropathy The American Journal of Pathology. Apr, 2014 | Pubmed ID: 24508230 Integrin CD11b Positively Regulates TLR4-induced Signalling Pathways in Dendritic Cells but Not in Macrophages Nature Communications. 2014 | Pubmed ID: 24423728 Interleukin-6 Signaling Drives Fibrosis in Unresolved Inflammation Immunity. Jan, 2014 | Pubmed ID: 24412616 Tissue-resident Macrophages Nature Immunology. Oct, 2013 | Pubmed ID: 24048120 Interleukin-6 Limits Influenza-induced Inflammation and Protects Against Fatal Lung Pathology European Journal of Immunology. Oct, 2013 | Pubmed ID: 23857287 Distinct Bone Marrow-derived and Tissue-resident Macrophage Lineages Proliferate at Key Stages During Inflammation Nature Communications. 2013 | Pubmed ID: 23695680 LAB/NTAL Facilitates Fungal/PAMP-induced IL-12 and IFN-γ Production by Repressing β-Catenin Activation in Dendritic Cells PLoS Pathogens. May, 2013 | Pubmed ID: 23675302 Phagocytosis is the Main CR3-mediated Function Affected by the Lupus-associated Variant of CD11b in Human Myeloid Cells PloS One. 2013 | Pubmed ID: 23451151 Differential Dependencies of Monocytes and Neutrophils on Dectin-1, Dectin-2 and Complement for the Recognition of Fungal Particles in Inflammation PloS One. 2012 | Pubmed ID: 23049859 Anti-inflammatory Activity of IgG1 Mediated by Fc Galactosylation and Association of FcγRIIB and Dectin-1 Nature Medicine. Aug, 2012 | Pubmed ID: 22922409 Development of Myeloproliferative Disease in 12/15-lipoxygenase Deficiency Blood. Jun, 2012 | Pubmed ID: 22730527 Macrophage Heterogeneity and Acute Inflammation European Journal of Immunology. Sep, 2011 | Pubmed ID: 21952806 A Quantifiable Proliferative Burst of Tissue Macrophages Restores Homeostatic Macrophage Populations After Acute Inflammation European Journal of Immunology. Aug, 2011 | Pubmed ID: 21710478 Restoration of Pattern Recognition Receptor Costimulation to Treat Chromoblastomycosis, a Chronic Fungal Infection of the Skin Cell Host & Microbe. May, 2011 | Pubmed ID: 21575914 In Vivo Functional Analysis and Genetic Modification of in Vitro-derived Mouse Neutrophils FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jun, 2011 | Pubmed ID: 21368104 Paracetamol Reduces Influenza-induced Immunopathology in a Mouse Model of Infection Without Compromising Virus Clearance or the Generation of Protective Immunity Thorax. May, 2011 | Pubmed ID: 21310755 Hoxb8 Conditionally Immortalised Macrophage Lines Model Inflammatory Monocytic Cells with Important Similarity to Dendritic Cells European Journal of Immunology. Feb, 2011 | Pubmed ID: 21268006 Fungal Recognition Enhances Mannose Receptor Shedding Through Dectin-1 Engagement The Journal of Biological Chemistry. Mar, 2011 | Pubmed ID: 21205820 Esterified Eicosanoids Are Acutely Generated by 5-lipoxygenase in Primary Human Neutrophils and in Human and Murine Infection Blood. Feb, 2011 | Pubmed ID: 21177434 Endogenous Oncogenic Nras Mutation Promotes Aberrant GM-CSF Signaling in Granulocytic/monocytic Precursors in a Murine Model of Chronic Myelomonocytic Leukemia Blood. Dec, 2010 | Pubmed ID: 20921338 Pathways Regulating Cytosolic Phospholipase A2 Activation and Eicosanoid Production in Macrophages by Candida Albicans The Journal of Biological Chemistry. Oct, 2010 | Pubmed ID: 20643646 The Myeloid 7/4-antigen Defines Recently Generated Inflammatory Macrophages and is Synonymous with Ly-6B Journal of Leukocyte Biology. Jul, 2010 | Pubmed ID: 20400676 Cytosolic Phospholipase A2 Activation by Candida Albicans in Alveolar Macrophages: Role of Dectin-1 American Journal of Respiratory Cell and Molecular Biology. Apr, 2010 | Pubmed ID: 19502385 Dectin-2 is a Syk-coupled Pattern Recognition Receptor Crucial for Th17 Responses to Fungal Infection The Journal of Experimental Medicine. Aug, 2009 | Pubmed ID: 19703985 Complement C3 Plays an Essential Role in the Control of Opportunistic Fungal Infections Infection and Immunity. Sep, 2009 | Pubmed ID: 19581397 Phosphatidylethanolamine-esterified Eicosanoids in the Mouse: Tissue Localization and Inflammation-dependent Formation in Th-2 Disease The Journal of Biological Chemistry. Aug, 2009 | Pubmed ID: 19531470 CLEC-2 is a Phagocytic Activation Receptor Expressed on Murine Peripheral Blood Neutrophils Journal of Immunology (Baltimore, Md. : 1950). Apr, 2009 | Pubmed ID: 19299712 The C-type Lectin SIGNR1 Binds Schistosoma Mansoni Antigens in Vitro, but SIGNR1-deficient Mice Have Normal Responses During Schistosome Infection Infection and Immunity. Jan, 2009 | Pubmed ID: 18981244 12/15-Lipoxygenase Regulates the Inflammatory Response to Bacterial Products in Vivo Journal of Immunology (Baltimore, Md. : 1950). Nov, 2008 | Pubmed ID: 18941242 The Induction of Inflammation by Dectin-1 in Vivo is Dependent on Myeloid Cell Programming and the Progression of Phagocytosis Journal of Immunology (Baltimore, Md. : 1950). Sep, 2008 | Pubmed ID: 18714028 Oncostatin M Receptor-beta Signaling Limits Monocytic Cell Recruitment in Acute Inflammation Journal of Immunology (Baltimore, Md. : 1950). Aug, 2008 | Pubmed ID: 18641356 Characterisation of Murine MICL (CLEC12A) and Evidence for an Endogenous Ligand European Journal of Immunology. Apr, 2008 | Pubmed ID: 18350551 Characterisation of the Expression and Function of the GM-CSF Receptor Alpha-chain in Mice European Journal of Immunology. Sep, 2007 | Pubmed ID: 17694571 3R Blackboard: A Platform for Animal and Organ Sharing Laboratory Animals. | Pubmed ID: 35023399 Macrophage Reprogramming for Therapy Immunology. | Pubmed ID: 33368269 Tissue-resident Macrophages Actively Suppress IL-1beta Release Via a Reactive Prostanoid/IL-10 Pathway The EMBO Journal. | Pubmed ID: 32484988 Effective Gene Modification in Mouse Tissue-Resident Peritoneal Macrophages by Intraperitoneal Delivery of Lentiviral Vectors Molecular Therapy. Methods & Clinical Development. | Pubmed ID: 31720306 Author Spotlight: Exploring Macrophage Immunometabolism Through Lentiviral Vector-Mediated Gene Manipulation Mark Gurney1, Luke C. Davies1,2, Ruth E. Jones1, Valentina M. Bart1, Robert H. Jenkins1, Paul Brennan1, Philip R. Taylor1,3, Magdalena A. Czubala1 1Systems Immunity Research Institute, Division of Infection and Immunity, Cardiff University, 2Biomedical Sciences Unit, Faculty of Medicine, Health and Life Science, Swansea University, 3UK Dementia Research Institute JoVE 64926 Immunology and Infection
Author Spotlight: Exploring Macrophage Immunometabolism Through Lentiviral Vector-Mediated Gene Manipulation Mark Gurney1, Luke C. Davies1,2, Ruth E. Jones1, Valentina M. Bart1, Robert H. Jenkins1, Paul Brennan1, Philip R. Taylor1,3, Magdalena A. Czubala1 1Systems Immunity Research Institute, Division of Infection and Immunity, Cardiff University, 2Biomedical Sciences Unit, Faculty of Medicine, Health and Life Science, Swansea University, 3UK Dementia Research Institute JoVE 64926 Immunology and Infection
