Seppo Parkkila

Faculty of Medicine and Health Technology, Tampere University

Affiliated withTampere University Tampere University Hospital

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 18	2019

Other Publications

Article	Year
Catalytically inactive carbonic anhydrase-related proteins enhance transport of lactate by MCT1. FEBS open bio\| PubMed ID: 31033227	2019
The plasma membrane carbonic anhydrase in murine hepatocytes identified as isozyme XIV. BMC gastroenterology\| PubMed ID: 12033992	2002
Carbonic anhydrase isozymes IX and XII in gastric tumors. World journal of gastroenterology\| PubMed ID: 12854129	2003
Expression of hypoxia-inducible, membrane-bound carbonic anhydrase isozyme XII in mouse tissues. The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology\| PubMed ID: 14983512	2004
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozyme XIII with aromatic and heterocyclic sulfonamides: a novel target for the drug design. Bioorganic & medicinal chemistry letters\| PubMed ID: 15203157	2004
Transmembrane carbonic anhydrase isozymes IX and XII in the female mouse reproductive organs. Reproductive biology and endocrinology : RB&E\| PubMed ID: 15488153	2004
Hepatic and extrahepatic expression of the new iron regulatory protein hemojuvelin. Haematologica\| PubMed ID: 15590393	2004
Carbonic anhydrases in normal gastrointestinal tract and gastrointestinal tumours. World journal of gastroenterology\| PubMed ID: 15633208	2005
Expression of a novel carbonic anhydrase, CA XIII, in normal and neoplastic colorectal mucosa. BMC cancer\| PubMed ID: 15836783	2005
Expression of von Hippel-Lindau tumor suppressor and tumor-associated carbonic anhydrases IX and XII in normal and neoplastic colorectal mucosa. World journal of gastroenterology\| PubMed ID: 15849821	2005
Characterization of CA XV, a new GPI-anchored form of carbonic anhydrase. The Biochemical journal\| PubMed ID: 16083424	2005
Carbonic anhydrase isozyme-II-deficient mice lack the duodenal bicarbonate secretory response to prostaglandin E2. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16217040	2005
Expression of carbonic anhydrases II, IV, VII, VIII and XII in rat brain after kainic acid induced status epilepticus. Neurochemistry international\| PubMed ID: 16271802	2006
Carbonic anhydrase gene expression in CA II-deficient (Car2-/-) and CA IX-deficient (Car9-/-) mice. The Journal of physiology\| PubMed ID: 16396925	2006
Expression of carbonic anhydrase IX in astrocytic tumors predicts poor prognosis. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 16428489	2006
Expression of carbonic anhydrases IX and XII during mouse embryonic development. BMC developmental biology\| PubMed ID: 16719910	2006
Carbonic anhydrase activators: activation of isozyme XIII with amino acids and amines. Bioorganic & medicinal chemistry letters\| PubMed ID: 16730978	2006
Expression of membrane-bound carbonic anhydrases IV, IX, and XIV in the mouse heart. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society\| PubMed ID: 16924128	2006
A systematic quantification of carbonic anhydrase transcripts in the mouse digestive system. BMC molecular biology\| PubMed ID: 17362527	2007
Carbonic anhydrase II in the endothelium of glial tumors: a potential target for therapy. Neuro-oncology\| PubMed ID: 17435181	2007
Characterization and inhibition of the recently discovered carbonic anhydrase isoforms CA XIII, XIV and XV. Current topics in medicinal chemistry\| PubMed ID: 17504134	2007
Effects of iron loading on muscle: genome-wide mRNA expression profiling in the mouse. BMC genomics\| PubMed ID: 17949489	2007
Carbonic anhydrase IX in oligodendroglial brain tumors. BMC cancer\| PubMed ID: 18173856	2008
The calcium-binding protein S100P in normal and malignant human tissues. BMC clinical pathology\| PubMed ID: 18282279	2008
Identification of an alternatively spliced isoform of carbonic anhydrase XII in diffusely infiltrating astrocytic gliomas. Neuro-oncology\| PubMed ID: 18322268	2008
Significance of pH regulation and carbonic anhydrases in tumour progression and implications for diagnostic and therapeutic approaches. BJU international\| PubMed ID: 18430117	2008
Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes. The Journal of biological chemistry\| PubMed ID: 18703501	2008
Modification of carbonic anhydrase II with acetaldehyde, the first metabolite of ethanol, leads to decreased enzyme activity. BMC biochemistry\| PubMed ID: 19036170	2008
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. Journal of medicinal chemistry\| PubMed ID: 19193158	2009
Expression of iron-related genes in human brain and brain tumors. BMC neuroscience\| PubMed ID: 19386095	2009
The protein tyrosine kinase inhibitors imatinib and nilotinib strongly inhibit several mammalian alpha-carbonic anhydrase isoforms. Bioorganic & medicinal chemistry letters\| PubMed ID: 19527930	2009
Global transcriptional response to Hfe deficiency and dietary iron overload in mouse liver and duodenum. PloS one\| PubMed ID: 19787063	2009
Phytochemicals as Modulators of Long Non-Coding RNAs and Inhibitors of Cancer-Related Carbonic Anhydrases. International journal of molecular sciences\| PubMed ID: 31208095	2019
Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19805286	2009
Carbonic anhydrase II. A novel biomarker for gastrointestinal stromal tumors. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc\| PubMed ID: 20081808	2010
The most recently discovered carbonic anhydrase, CA XV, is expressed in the thick ascending limb of Henle and in the collecting ducts of mouse kidney. PloS one\| PubMed ID: 20224780	2010
Specific expression profile and prognostic significance of peroxiredoxins in grade II-IV astrocytic brain tumors. BMC cancer\| PubMed ID: 20307276	2010
Phylogeny and expression of carbonic anhydrase-related proteins. BMC molecular biology\| PubMed ID: 20356370	2010
The tumour-associated carbonic anhydrases CA II, CA IX and CA XII in a group of medulloblastomas and supratentorial primitive neuroectodermal tumours: an association of CA IX with poor progn... BMC cancer\| PubMed ID: 20398423	2010
Analysis of a shortened form of human carbonic anhydrase VII expressed in vitro compared to the full-length enzyme. Biochimie\| PubMed ID: 20493921	2010
Carbonic anhydrases II and XII are up-regulated in osteoclast-like cells in advanced human atherosclerotic plaques-Tampere Vascular Study. Annals of medicine\| PubMed ID: 20509747	2010
Global transcriptional response to carbonic anhydrase IX deficiency in the mouse stomach. BMC genomics\| PubMed ID: 20573196	2010
Characterization of the first beta-class carbonic anhydrase from an arthropod (Drosophila melanogaster) and phylogenetic analysis of beta-class carbonic anhydrases in invertebrates. BMC biochemistry\| PubMed ID: 20659325	2010
Novel carbonic anhydrase autoantibodies and renal manifestations in patients with primary Sjogren's syndrome. Rheumatology (Oxford, England)\| PubMed ID: 21427176	2011
Acetaldehyde-derived modifications on cytosolic human carbonic anhydrases. Journal of enzyme inhibition and medicinal chemistry\| PubMed ID: 21679053	2011
Oral colonization by Streptococcus mutans and caries development is reduced upon deletion of carbonic anhydrase VI expression in saliva. Biochimica et biophysica acta\| PubMed ID: 21945428	2011
Characterization of non-specific cytotoxic cell receptor protein 1: a new member of the lectin-type subfamily of F-box proteins. PloS one\| PubMed ID: 22087255	2011
Serendipitous fragment-based drug discovery: ketogenic diet metabolites and statins effectively inhibit several carbonic anhydrases. Chemical communications (Cambridge, England)\| PubMed ID: 22382897	2012
Characterization, bioinformatic analysis and dithiocarbamate inhibition studies of two new α-carbonic anhydrases, CAH1 and CAH2, from the fruit fly Drosophila melanogaster. Bioorganic & medicinal chemistry\| PubMed ID: 22989910	2013
Cloning, characterization, and sulfonamide and thiol inhibition studies of an α-carbonic anhydrase from Trypanosoma cruzi, the causative agent of Chagas disease. Journal of medicinal chemistry\| PubMed ID: 23391336	2013
Anion inhibition studies of the α-carbonic anhydrase from the protozoan pathogen Trypanosoma cruzi, the causative agent of Chagas disease. Bioorganic & medicinal chemistry\| PubMed ID: 23790722	2013
Bioinformatic analysis of beta carbonic anhydrase sequences from protozoans and metazoans. Parasites & vectors\| PubMed ID: 24447594	2014
Hsp27 and its expression pattern in diffusely infiltrating astrocytomas. Histology and histopathology\| PubMed ID: 24599602	2014
Expression patterns and subcellular localization of carbonic anhydrases are developmentally regulated during tooth formation. PloS one\| PubMed ID: 24789143	2014
Sulfonamide inhibition studies of the β carbonic anhydrase from Drosophila melanogaster. Bioorganic & medicinal chemistry letters\| PubMed ID: 24852120	2014
The role of carbonic anhydrase VI in bitter taste perception: evidence from the Car6⁻/⁻ mouse model. Journal of biomedical science\| PubMed ID: 25134447	2014
Beta carbonic anhydrases: novel targets for pesticides and anti-parasitic agents in agriculture and livestock husbandry. Parasites & vectors\| PubMed ID: 25174433	2014
The β-carbonic anhydrase from the malaria mosquito Anopheles gambiae is highly inhibited by sulfonamides. Bioorganic & medicinal chemistry\| PubMed ID: 25882523	2015
Inactivation of ca10a and ca10b Genes Leads to Abnormal Embryonic Development and Alters Movement Pattern in Zebrafish. PloS one\| PubMed ID: 26218428	2015
β carbonic anhydrase is required for female fertility in Drosophila melanogaster. Frontiers in zoology\| PubMed ID: 26300950	2015
Ascaris lumbricoides β carbonic anhydrase: a potential target enzyme for treatment of ascariasis. Parasites & vectors\| PubMed ID: 26385556	2015
Discovery of 1,1'-Biphenyl-4-sulfonamides as a New Class of Potent and Selective Carbonic Anhydrase XIV Inhibitors. Journal of medicinal chemistry\| PubMed ID: 26497049	2015
Innovative molecular diagnosis of Trichinella species based on β-carbonic anhydrase genomic sequence. Microbial biotechnology\| PubMed ID: 26639312	2016
Horizontal transfer of β-carbonic anhydrase genes from prokaryotes to protozoans, insects, and nematodes. Parasites & vectors\| PubMed ID: 26983858	2016
Carbonic anhydrase IX deposits are associated with increased ascending aortic dilatation. Scandinavian cardiovascular journal : SCJ\| PubMed ID: 27157093	2016
Altered gene expression in the lower respiratory tract of Car6 (-/-) mice. Transgenic research\| PubMed ID: 27209317	2016
Identification and inhibition of carbonic anhydrases from nematodes. Journal of enzyme inhibition and medicinal chemistry\| PubMed ID: 27557594	2016
Fluorinated benzenesulfonamide anticancer inhibitors of carbonic anhydrase IX exhibit lower toxic effects on zebrafish embryonic development than ethoxzolamide. Drug and chemical toxicology\| PubMed ID: 27600313	2017
Carbonic anhydrase enzymes II, VII, IX and XII in colorectal carcinomas. World journal of gastroenterology\| PubMed ID: 27688658	2016
Anti-carbonic anhydrase autoantibodies and serum beta-2 microglobulin correlate with the ClinESSDAI score in patients with Sjögren's syndrome. Clinical and experimental rheumatology\| PubMed ID: 28079504	2017
Carbonic anhydrase II: a novel biomarker for pseudomyxoma peritonei. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica\| PubMed ID: 28233447	2017
Role of carbonic anhydrases in skin wound healing. Experimental & molecular medicine\| PubMed ID: 28524177	2017
β-CA-specific inhibitor dithiocarbamate Fc14-584B: a novel antimycobacterial agent with potential to treat drug-resistant tuberculosis. Journal of enzyme inhibition and medicinal chemistry\| PubMed ID: 28629306	2017
Identification and characterization of a novel zebrafish (Danio rerio) pentraxin-carbonic anhydrase. PeerJ\| PubMed ID: 29230365	2017
Surveillance and diagnosis of zoonotic foodborne parasites. Food science & nutrition\| PubMed ID: 29387356	2018
An Update on the Metabolic Roles of Carbonic Anhydrases in the Model Alga Chlamydomonas reinhardtii. Metabolites\| PubMed ID: 29534024	2018
Activation studies with amines and amino acids of the β-carbonic anhydrase from the pathogenic protozoan Leishmania donovani chagasi. Bioorganic chemistry\| PubMed ID: 29689418	2018
Carbonic anhydrase related protein expression in astrocytomas and oligodendroglial tumors. BMC cancer\| PubMed ID: 29792187	2018
Involvement of β-Carbonic Anhydrase Genes in Bacterial Genomic Islands and Their Horizontal Transfer to Protists. Applied and environmental microbiology\| PubMed ID: 29802189	2018
Nitroimidazole-based inhibitors DTP338 and DTP348 are safe for zebrafish embryos and efficiently inhibit the activity of human CA IX in Xenopus oocytes. Journal of enzyme inhibition and medicinal chemistry\| PubMed ID: 29909747	2018
Weak HIF-1alpha expression indicates poor prognosis in resectable pancreatic ductal adenocarcinoma. World journal of surgical oncology\| PubMed ID: 29973215	2018
Activation studies with amines and amino acids of the α-carbonic anhydrase from the pathogenic protozoan Trypanosoma cruzi. Bioorganic & medicinal chemistry\| PubMed ID: 30007565	2018
Carbonic anhydrases II, IX, and XII in Barrett's esophagus and adenocarcinoma. Virchows Archiv : an international journal of pathology\| PubMed ID: 30066203	2018
Toll-like receptors 2, 4 and 9 and hypoxia markers HIF-1alpha and CAIX in pancreatic intraepithelial neoplasia. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica\| PubMed ID: 30357962	2018
Carbonic Anhydrase Inhibitors as Novel Drugs against Mycobacterial β-Carbonic Anhydrases: An Update on and Studies. Molecules (Basel, Switzerland)\| PubMed ID: 30413024	2018
Cloning, Characterization and Anion Inhibition Studies of a β-Carbonic Anhydrase from the Pathogenic Protozoan . Molecules (Basel, Switzerland)\| PubMed ID: 30486513	2018
R-Ras regulates vascular permeability, but not overall healing in skin wounds. Experimental dermatology\| PubMed ID: 30489650	2019
Sulfonamide Inhibition Studies of a New β-Carbonic Anhydrase from the Pathogenic Protozoan . International journal of molecular sciences\| PubMed ID: 30544802	2018
Activation Studies of the β-Carbonic Anhydrase from the Pathogenic Protozoan with Amino Acids and Amines. Metabolites\| PubMed ID: 30717275	2019
Discovery of new organoselenium compounds as antileishmanial agents. Bioorganic chemistry\| PubMed ID: 30743174	2019