William L. Dewey

Pharmacology and Toxicology, Virginia Commonwealth University

Affiliated withVirginia Commonwealth University

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 66	2013

Other Publications

Article	Year
Prolonged reversal of morphine tolerance with no reversal of dependence by protein kinase C inhibitors. Brain research\| PubMed ID: 12468027	2002
The expression of a high level of morphine antinociceptive tolerance in mice involves both PKC and PKA. Brain research\| PubMed ID: 12957370	2003
Effects of mGlu1 and mGlu5 metabotropic glutamate antagonists to reverse morphine tolerance in mice. European journal of pharmacology\| PubMed ID: 15178357	2004
PKC and PKA inhibitors reverse tolerance to morphine-induced hypothermia and supraspinal analgesia in mice. European journal of pharmacology\| PubMed ID: 15178359	2004
Task specificity of cross-tolerance between Delta9-tetrahydrocannabinol and anandamide analogs in mice. European journal of pharmacology\| PubMed ID: 15740725	2005
Alterations in brain Protein Kinase A activity and reversal of morphine tolerance by two fragments of native Protein Kinase A inhibitor peptide (PKI). Neuropharmacology\| PubMed ID: 15814100	2005
Chronic Delta9-tetrahydrocannabinol treatment produces antinociceptive tolerance in mice without altering protein kinase A activity in mouse brain and spinal cord. Biochemical pharmacology\| PubMed ID: 15913565	2005
Protein Kinase A activity is increased in mouse lumbar spinal cord but not brain following morphine antinociceptive tolerance for 15 days. Pharmacological research : the official journal of the Italian Pharmacological Society\| PubMed ID: 16026714	2005
Protein kinase inhibitor peptide (PKI): a family of endogenous neuropeptides that modulate neuronal cAMP-dependent protein kinase function. Neuropeptides\| PubMed ID: 16442618	2006
Pharmacological characterization of novel water-soluble cannabinoids. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 16757541	2006
Determination of the role of conventional, novel and atypical PKC isoforms in the expression of morphine tolerance in mice. Pain\| PubMed ID: 16965856	2007
How important is protein kinase C in mu-opioid receptor desensitization and morphine tolerance? Trends in pharmacological sciences\| PubMed ID: 17000011	2006
PKC and PKA inhibitors reinstate morphine-induced behaviors in morphine tolerant mice. Pharmacological research : the official journal of the Italian Pharmacological Society\| PubMed ID: 17056270	2006
Decrease in N-methyl-D-aspartic acid receptor-NR2B subunit levels by intrathecal short-hairpin RNA blocks group I metabotropic glutamate receptor-mediated hyperalgesia. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 17405869	2007
Synthesis and pharmacological evaluation of phenylethynyl[1,2,4]methyltriazines as analogues of 3-methyl-6-(phenylethynyl)pyridine. Journal of medicinal chemistry\| PubMed ID: 17569516	2007
Evidence for an important role of protein phosphatases in the mechanism of morphine tolerance. Brain research\| PubMed ID: 17582387	2007
mGluR5 antagonists that block calcium mobilization in vitro also reverse (S)-3,5-DHPG-induced hyperalgesia and morphine antinociceptive tolerance in vivo. Brain research\| PubMed ID: 18022146	2008
Local production of O2- by NAD(P)H oxidase in the sarcoplasmic reticulum of coronary arterial myocytes: cADPR-mediated Ca2+ regulation. Cellular signalling\| PubMed ID: 18207366	2008
Pre-treatment with a PKC or PKA inhibitor prevents the development of morphine tolerance but not physical dependence in mice. Brain research\| PubMed ID: 18501877	2008
Morphine tolerance in the mouse ileum and colon. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 18682567	2008
Formation and function of ceramide-enriched membrane platforms with CD38 during M1-receptor stimulation in bovine coronary arterial myocytes. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 18723763	2008
Design, synthesis, and biological evaluation of 6alpha- and 6beta-N-heterocyclic substituted naltrexamine derivatives as mu opioid receptor selective antagonists. Journal of medicinal chemistry\| PubMed ID: 19199782	2009
Chronic constriction injury reduces cannabinoid receptor 1 activity in the rostral anterior cingulate cortex of mice. Brain research\| PubMed ID: 20380816	2010
Role of CD38, a cyclic ADP-ribosylcyclase, in morphine antinociception and tolerance. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 20551293	2010
Î¼-opioid receptors: correlation of agonist efficacy for signalling with ability to activate internalization. Molecular pharmacology\| PubMed ID: 20647394	2010
Chronic neuropathic pain in mice reduces Î¼-opioid receptor-mediated G-protein activity in the thalamus. Brain research\| PubMed ID: 21762883	2011
The role of Î²-arrestin2 in the mechanism of morphine tolerance in the mouse and guinea pig gastrointestinal tract. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 22129596	2012
Opioid-induced hypernociception is associated with hyperexcitability and altered tetrodotoxin-resistant Na+ channel function of dorsal root ganglia. American journal of physiology. Cell physiology\| PubMed ID: 22189556	2012
Differences in the characteristics of tolerance to Î¼-opioid receptor agonists in the colon from wild type and Î²-arrestin2 knockout mice. European journal of pharmacology\| PubMed ID: 22521552	2012
Morphine efficacy is altered in conditional HIV-1 Tat transgenic mice. European journal of pharmacology\| PubMed ID: 22659585	2012
6Î²-N-heterocyclic substituted naltrexamine derivative NAP as a potential lead to develop peripheral mu opioid receptor selective antagonists. Bioorganic & medicinal chemistry letters\| PubMed ID: 22683223	2012
Production and actions of the anandamide metabolite prostamide E2 in the renal medulla. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 22685343	2012
Evidence for the putative cannabinoid receptor (GPR55)-mediated inhibitory effects on intestinal contractility in mice. Pharmacology\| PubMed ID: 22759743	2012
Characterization of 6Î±- and 6Î²-N-heterocyclic substituted naltrexamine derivatives as novel leads to development of mu opioid receptor selective antagonists. ACS chemical neuroscience\| PubMed ID: 22816021	2011
Contribution of acid sphingomyelinase in the periaqueductal gray region to morphine-induced analgesia in mice. Neuroreport\| PubMed ID: 22825003	2012
Morphine decreases enteric neuron excitability via inhibition of sodium channels. PloS one\| PubMed ID: 23028881	2012
Design, synthesis, and biological evaluation of 17-cyclopropylmethyl-3,14Î²-dihydroxy-4,5Î±-epoxy-6Î²-[(4'-pyridyl)carboxamido]morphinan derivatives as peripheral selective Î¼ opioid recepto... Journal of medicinal chemistry\| PubMed ID: 23116124	2012
Electrophysiological characteristics of enteric neurons isolated from the immortomouse. Digestive diseases and sciences\| PubMed ID: 23371009	2013
Ethanol reversal of cellular tolerance to morphine in rat locus coeruleus neurons. Molecular pharmacology\| PubMed ID: 23716621	2013