Jiangsu University Hospital 1 article published in JoVE Medicine Generation of a Humanized Mouse Liver Using Human Hepatic Stem Cells Ran-Ran Zhang*1, Yun-Wen Zheng*1,2,3, Hideki Taniguchi1 1Department of Regenerative Medicine, Graduate School of Medicine, Yokohama City University, 2Department of Advanced Gastroenterological Surgical Science and Technology, Faculty of Medicine, University of Tsukuba, 3Regenerative Medicine Research Center, Jiangsu University Hospital Here, we present a novel humanized mouse liver model generated in Alb-toxin receptor mediated cell knockout (TRECK)/SCID mice following the transplantation of immature and expandable human hepatic stem cells.