Perfect Life and Health Institute 1 article published in JoVE Neuroscience Caenorhabditis elegans as a Model System for Discovering Bioactive Compounds Against Polyglutamine-Mediated Neurotoxicity Qiangqiang Wang*1, Ju Zhang*2, Yiyi Jiang1,3, Yue Xiao1, Xiaomin Li3, Xinliang Mao3, Zebo Huang1 1Institute for Food Nutrition and Human Health, School of Food Science and Engineering, South China University of Technology, 2School of Bioscience and Bioengineering, Hebei University of Economics and Business, 3Perfect Life & Health Institute Here, we present a protocol to assess the neuroprotective activities of test compounds in Caenorhabditis elegans, including polyglutamine aggregation, neuronal death, and chemoavoidance behavior, as well as an exemplary integration of multiple phenotypes.
