Obihiro University of Agriculture and Veterinary Medicine 1 article published in JoVE Behavior Measuring Active and Passive Tameness Separately in Mice Hiromichi Nagayama1,2, Yuki Matsumoto1,2, Akira Tanave1, Motoko Nihei1, Tatsuhiko Goto3, Tsuyoshi Koide1,2 1Mouse Genomics Resource Laboratory, National Institute of Genetics, 2Department of Genetics, SOKENDAI (The Graduate University for Advanced Studies), 3Research Center for Global Agromedicine, Obihiro University of Agriculture and Veterinary Medicine Tameness in animals includes a reduction of avoidance responses to humans (passive tameness) and an increase in active approaches to humans (active tameness). Here, we describe detailed protocols for three behavioral tests (active tameness, passive tameness, and stay-on-hand tests) to separately measure the active and passive tameness of mice.